Curcumin as a Multifunctional Spice Ingredient against Mental Disorders in Humans: Current Clinical Studies and Bioavailability Concerns.

BACKGROUND: Mental disorders in terms of depression, anxiety, and stress are one of the major causes of burden globally. Over the last two decades, the use of plant-based substances in the treatment of mental disorders in combination or not with medication has increasingly attracted the interest of the scientific research community. However, even if there is a plethora of naturally occurring bioactive compounds, most of them have low bioavailability, rendering them unable to insert into the bloodstream to exert their biological activities. METHODS: This is a comprehensive narrative review that critically summarizes and scrutinizes the new approaches to the treatment of mental disorders using curcumin, also highlighting its bioavailability properties. The most accurate were searched using effective and relevant keywords. RESULTS: This narrative review reveals substantial evidence that curcumin can exert significant effects on several mental disorders. However, despite the low cost, the extensive and confirmed potency of curcumin and its involvement in signaling pathways and the scientifically confirmed data regarding its molecular mechanisms of action against mental disorders, this naturally occurring compound presents low oral bioavailability. Pharmaceutical technology has provided solutions to increase the bioavailability of curcumin. Combination with piperine, galactomannosides, liposomal formulation or nanoformulation overcomes the bioavailability and solubility disadvantages. CONCLUSIONS: Although curcumin demonstrates anti-anxiety, anti-depressive and anti-stress properties, studies on humans are limited and heterogeneous. Further research is highly recommended to determine the most functional formula, dose, duration, and possible side effects of curcumin on mental disorders in humans. Based on the current knowledge, the curcumin nanoformulation and Theracurmin, a form of colloidal submicroscopic particles, seem to be the most effective bioavailable formulations, which may be examined in future clinical human studies.

Whistleblowing against doping in sport: A cross-national study on the effects of motivation and sportspersonship orientations on whistleblowing intentions.

Whistleblowing against anti-doping rule violations and related misconduct has been recognized as an important deterrent of doping behaviour in competitive sport. However, research on whistleblowing against doping is scarce and the available studies have focused on small samples using qualitative and inductive approaches. The present study used quantitative methods to assess, for the first time, the association between self-determined motivation, achievement goals, sportspersonship orientations and intentions to engage in whistleblowing against doping misconduct. A total of 992 competitive athletes from Greece (n = 480) and Russia (n = 512) completed structured measures of self-determination, achievement goals, sportspersonship orientation beliefs, and intentions to report doping misconduct. Latent profile analysis classified athletes into clusters consistent with the theoretical predictions. One-way analyses of variance further showed consistently across countries that autonomous motivated athletes reported higher intentions to whistleblow, and athletes with higher scores in achievement goals and sportspersonship orientations had significantly higher scores in whistleblowing intentions, compared to those with lower scores in these characteristics in both countries. This is the first study to demonstrate the association between motivational regulations, achievement goals, sportspersonship beliefs, and whistleblowing intentions. The theoretical and policy implications of our study are discussed.

Are nutritional supplements a gateway to doping use in competitive team sports? The roles of achievement goals and motivational regulations.

OBJECTIVES: The study investigated the moderating role of achievement goals and motivation regulations on the association between self-reported nutritional supplement (NS) use, doping likelihood, and self-reported doping behaviour among competitive athletes. METHOD: Four hundred and ninety seven competitive team sport athletes (64% males; M age=23.54 years, SD=5.75) completed anonymous questionnaires measuring self-reported use of prohibited substances and licit NS; beliefs about the "gateway" function of NS; achievement goals; and motivational regulations. RESULTS: Hierarchical linear regression analysis showed that self-reported doping was associated (Adjusted R2=33%) with NS use, a stronger belief that NS use acts as a gateway to doping, amotivation, controlled motivation, mastery approach, and performance avoidance goals. Higher likelihood to use doping substances in the future was associated (Adjusted R2=41.7%) with current NS use, stronger belief that NS act as a gateway to doping, autonomous motivation, and performance avoidance goals. A series of moderated regression analyses showed that NS use significantly interacted with mastery approach, mastery avoidance, performance avoidance goals, autonomous motivation controlled motivation, and with amotivation in predicting self-reported doping. Finally, NS use significantly interacted with mastery approach goals, performance avoidance goals, and controlled motivation in predicting future doping likelihood. CONCLUSIONS: Achievement goals and motivational regulations are differentially associated with both doping likelihood and self-reported doping, and may account for the observed association between self-reported NS use and doping substances; thus, providing an alternative explanation to the "gateway hypothesis" that emphasizes the role of motivation.

Tackling psychosocial risk factors for adolescent cyberbullying: Evidence from a school-based intervention.

Cyberbullying is an emerging form of bullying that takes place through contemporary information and communication technologies. Building on past research on the psychosocial risk factors for cyberbullying in this age group, the present study assessed a theory-driven, school-based preventive intervention that targeted moral disengagement, empathy and social cognitive predictors of cyberbullying. Adolescents (N = 355) aged between 16 and 18 years were randomly assigned into the intervention and the control group. Both groups completed anonymous structured questionnaires about demographics, empathy, moral disengagement and cyberbullying-related social cognitive variables (attitudes, actor prototypes, social norms, and behavioral expectations) before the intervention, post-intervention and 6 months after the intervention. The intervention included awareness-raising and interactive discussions about cyberbullying with intervention group students. Analysis of covariance (ANCOVA) showed that, after controlling for baseline measurements, there were significant differences at post-intervention measures in moral disengagement scores, and in favorability of actor prototypes. Further analysis on the specific mechanisms of moral disengagement showed that significant differences were observed in distortion of consequences and attribution of blame. The implications of the intervention are discussed, and guidelines for future school-based interventions against cyberbullying are provided.

Ashtrays and signage as determinants of a smoke-free legislation's success.

INTRODUCTION: Successful smoke-free legislation is dependent on political will, enforcement and societal support. We report the success and pitfalls of a non-enforced nationwide smoke-free legislation in Greece, as well as ways in which compliance and enforcement-related factors, including ashtrays and signage, may impact indoor secondhand smoke (SHS) concentrations. METHODS: A follow-up study of venues (n=150, at baseline, n=75 at 2-year follow-up) in Greece assessed indoor particulate matter with a diameter less than 2.5 micrometers (PM 2.5 ) concentrations attributable to SHS smoke every six months for two years (n=455 venue/measurements). RESULTS: Following the implementation of the 2010 smoke-free legislation, mean PM2.5 concentrations attributable to SHS fell from 175.3 µg/m(3) pre-ban to 84.52 µg/m(3) immediately post-ban, increasing over subsequent waves (103.8 µg/m(3) and 158.2 µg/m(3) respectively). Controlling for potential influential factors such as ventilation, time of day, day of week, city and venue type, all post-ban measurements were still lower than during the pre-ban period (Wave 2 beta: -118.7, Wave 3 beta: -87.6, and Wave 4 beta: -69.9). Outdoor or indoor signage banning smoking was not found to affect SHS concentrations (beta: -10.9, p=0.667 and beta: -18.1, p=0.464 respectively). However, ashtray or ashtray equivalents were strong determinants of the existence of indoor SHS (beta: +67 µg/m(3), p=0.017). CONCLUSIONS: While the public may be supportive of smoke-free legislation, adherence may decline rapidly if enforcement is limited or nonexistent. Moreover, enforcement agencies should also focus on the comprehensive removal of ashtray equivalents that could act as cues for smoking within a venue.