[Professor Boris Petrovich Ugryumov is a prominent military pathologist]. / Professor Boris Petrovich Ugryumov ­ vidnyi voennyi patologoanatom.

The biographical article is dedicated to the memory of Boris Petrovich Ugryumov, a graduate of the Imperial Military Medical Academy (1914), a prominent military pathologist, the First Head of the Department of Pathological Anatomy, Ryazan Medical Institute. The paper presents the major milestones in the life of B.P. Ugryumov; his service on the fronts of the First and Second World Wars and his teaching activity at the Military Medical Academy and the Naval Medical Academy occupy an important place. For about 10 years, he was in charge of the Pathology Department, S.P. Botkin Clinical Infectious Diseases Hospital in Leningrad, which largely determined the area of his professional interests, such as the pathomorphology of infectious diseases, tuberculosis in particular. The archiving and personal photographic documents that have been previously unknown to the public are published for the first time.

[Prostate cancer and dogs sense of smell: opportunities of noninvasive diagnostics].

INTRODUCTION: A screening of prostate cancer is an important problem of healthcare system worldwide. AIM: To evaluate a possibility and efficiency of Belgian Malinois dogs sense of smell in diagnosis of prostate cancer. MATERIALS AND METHODS: Urine samples from 176 men were assessed. Of these, 112 samples were taken from patients with biopsy-proven prostate cancer, and 64 from healthy young men. The study with two Belgian Malinois dogs consisted of two stages. The first stage was to train the dogs to distinguish the urine of patients with prostate cancer. A total of 66 urine samples were used at this stage (from 42 patients with prostate cancer and 24 healthy people). At the second detection stage, urine samples of patients with prostate cancer was identified. A total of 110 urine samples were evaluated (70 patients with prostate cancer and 40 healthy people). RESULTS: The first dog correctly identified 68 samples from patients with prostate cancer, and in 37 cases it indicated the absence of disease (sensitivity 97.1%, specificity 92.5%, accuracy 95.4%). The second animal correctly identified 69 and 39 samples, respectively (sensitivity 98.6%, specificity 97.5%, accuracy 98.2%). CONCLUSION: A possibility of training dogs to identify patients with prostate cancer has been demonstrated. Further studies dedicated to the detection of volatile organic compounds in the urine using specialized analyzers of "electronic nose" type, as well as gas chromatography in combination with mass spectrometry, are of both scientific and practical interest.

[Forum of military physicians of Asia Pacific region].

Forum of military physicians of Asia Pacific region. Authors proviae a report about the 3rd Military medical Asia Pacific congress, which was held in August 2016 in Saint Petersburg under the authority of the International military medical committee. Within the frame of the congress was held regional workshop, in the course of which was heard a report of the Thailand representative, requests of observer states for the entry. The country, which will hold the 4th Military medical Asia Pacific congress, is Iran. On the last day of the congress delegates visited the finals of the Military-medical race of the military physicians profession skill competition within <.

[Recovery after deep defects of the fingers covering tissues in daily surgical hospital].

The article describes the experience of reconstructive and restorative operative treatment of patients with, defects of the skin of the fingers at the daily surgical hospital. It is shown that surgeons applying standard instruments and having additional training in hand surgery, using a technique non -free skin plastic flap on a temporary pedicle and using inpatient technology, get cosmetic and functional results compared to-those of treatment in hospitals. Cited in -the article data on the direct and separate treatment outcomes, quility of life of patients, the estimated non-specfic and organ-specific method, clearly show that non-free skin plastic flap on a temporary pedicle - a reliable and effective method of restoration of the skin fingers defects which can be accompanied wit the use of resource-saving technologies in health care.

[Anniversary of the science regulatory body of the S. M. Kirov Military medical academy].

Anniversary of the science regulatory body of the S.M.Kirov Military medical academy. In the nineteenth century the Military-medical scientific committee was responsible for organization of scientific activity in the system of medical service of the Armed Forces; in the soviet period - the Military-scientific committee of the Main military-medical authority (since 1930) and scientific department of the S.M.Kirov Military medical academy (since 1931). In 1931-1936 and in 2010-2014 the Military-scientific committee of the Main military- medical authority was dissolved, and in 1936-1940 and in 2014-2015 conducted a supernumerary activity, during these periods the scientific department of the S.MKirov Military medical academy was responsible for coordination of scientific work in the Armed Forces. An experience of organization of the scientific regulatory bodies brought positive results and allows developing medical science further in the interests of the Army and the Navy.

[Graduate of the S.M.Kirov Military-medical academy Fedor Levin: on the way to discovery of DNA].

Biochemist Fedor Aronovich LeviN (1869-1940) graduated with honours from the S.M.Kirov Military Medical Academy in St. Petersburg in 1891 where he had received a fundamental knowledge from A.P.Dianin and I.P.Pavlov, and then he immigrated to the US. More than three and a half decades of his successful research at the Rockefeller Institute for Medical Research contributed to the foundation of the doctrine of nucleic acids. Scientists, who continued to research nucleic acids, were awarded the Nobel Prize, but Levin and his contribution were forgotten. The authors of the given article didn't found any source in Russian about this prominent biochemist of the 20th century and member of the Russian scientific school. The purpose of the article is to acquaint the reader with a scientific biography of the scientist. who became, without exaggeration, one of the founders of modern genetics.

[The use of percutaneous endoscopic gastrostomy for provision of the long-term enteral nutrition].

Percutaneous endoscopic gastrostomy for provision of the long-term enteral nutrition is well established in clinical practice because unlike from traditional gastrostomy and jejunostomy allowed to avoid many complications. The technique is used for enteral tube feeding in the absence of real positive predictive recovery of consciousness and swallowing function. During presented study from 387 patients with a gastrostomy imposed by percutaneous endoscopic technique, observed only 1,8% of suppurative complications and in 1% of cases - uncontrolled removal of the tube by the patient. Our experience allows us to recommend this technique for wide implementation in practice of medical institutions in case when it is necessity in enteral feeding more than 3 weeks of patients with impaired

[Diagnosis and treatment of achalasia cardiae].

Achalasia is a progressive oesophageal motility disorder of unstudied aetiology involving the smooth muscle layer of the oesophagus. Insufficient knowledge of the pathogenesis of achalasia and the lack of clear treatment approaches has led to an increase of advanced disease forms. Common clinical manifestations of the disease are: incomplete LES relaxation, non-specific initial manifestations and as a result late medical seeking. Occurrence of achalasia cardiae is significantly low, therefore it is important to analyse the available clinical data. The article presents an experience of treatment of 30 patients over the last 16 years of observation. The average age of patients was 50, 5 years; insignificant male predominance is noted. III or IV disease state was diagnosed in 86.7% of patients; this diagnosis was confirmed by esophagogastroduodenoscopy. In the group of 24 patients who underwent attempted endoscopic dilatation of the cardiae, most of the included patients with stage II and III disease. Immediate good and satisfactory results of endoscopic treatment were obtained in 20 patients (83.3%), in 4 cases (16.7%) developed recurrent disease.

[Treatment of benign esophageal stricture].

The article presents an analysis of long-term experience of treatment of 128 patients with benign esophagus and esophageal anastomosis strictures in Kirov Military Medical Academy. This significant data included all possible variations of scarry esophageal strictures according their etiology, localization and the extension. The wide range of methods, which involved the different variants of bouginage, balloon dilation, stenting, electrosurgical dissection and resection of the stomach, were applied in treatment of the patients. The analysis of immediate and long-term results allowed detecting the criteria of choice and indication for use of the methods or their combination. Practical recommendations reflect the strategy of each variant of treatment and have the specific character. Possible complications and negative results of irrational application of different methods were presented. The immediate and long-term results gave evidence of the successful treatment of the patients with scarry esophagus and esophageal anastomosis strictures.

[Military postgraduate courses at the Military Medical Academy: history, current state and prospects].

Training of scientific and scientific-pedagogical staff is one of the most important tasks of any high school. The problem of staff training arose in the Kirov Military Medical (Medical Surgical) Academy before its official foundation. In 1741 first scholars were sent abroad for the preparation of theses. The scholars were supposed to return to the hospital schools for teaching activity. Since 1802 scholars have defended their theses in the Academy. In 1858 special medical institute, the prototype of the Institute for postgraduate military studies was established. Many outstanding scientists studied in the Academy and brought name of the Academy into repute. At the present time, the Institute of postgraduate military studies (postgraduate) of the Kirov Military Medical Academy continues to train scientific staff. The Institute of postgraduate military studies remains one of the most successful institutes in Russia.

[Department of training of physicians (for Missile Forces and Army) of Military-medical academy n. a. S.M.Kirov celebrates the 70th anniversary].

The article is dedicated to the history of the one of educational units of the Kirov Medical Academy. Department of training of physicians (for Missile Forces and Army) traces its origins to 1942 published in the resolution of the State Committee of Defense of the USSR, but in fact is the successor to hospital schools in the land and the Admiralty hospitals.

[From the history of military-medical education in XVIII century].

The article deals with the development of national medical education. The above materials are based mainly on archival material, published documents and publications of military history topics. The authors have shown that even with the publication of the decree on the construction (01.24.1715), and the tab (Spring 1715), Overland, and hospitals Admiralty in St. Petersburg, Peter the Great planned to their clinical status. However, construction was delayed until 1732, when it became a possibility of teaching, and almost immediately was royally endorsed a report on the state Medical Collegium, which determined the number of teaching staff and students. In the 1730's attempts to prepare highly qualified teachers of special schools for the hospital, and in 1742 already appears first full-time professor. Completed the period of formation can be considered in 1754, when P.Z.Kondoidi signed a decree on a new preparation for doctors with a 7-year period of training.

[Possibilities of outpatient surgery].

The main types of hospital-substituting technologies, their material and technical basis and possibilities of outpatient medical help are described in the article. Suggestions concerning further development of hospital-substituting technologies are presented by second congress of Russian outpatient surgeons.

[The oldest military hospitals of Saint-Petersburg: good round figure in history].

In 1710 in a under construction capital of the Russian state the first central military hospital for treatment the soldier of garrison has been organized. Its initial device differed from existed regimental infirmaries a little; however personal home nursing of tsar has helped development of hospital. In 1715 the hospital has been solemnly consecrated. Since 1735 in hospital have started to spend training of future doctors and with the basis in 1798 of Army medical college it became its clinical base. During teamwork the hospital became high-grade clinical base of academy, has developed and became the modem well equipped clinic-diagnostic centre.

Structural basis for the binding affinity of a homologous series of synthetic phenoxazone drugs with DNA: NMR and molecular mechanics analysis.

The molecular basis of the marked structure-activity relationship for a homologous series of DNA-binding phenoxazone drugs (ActII-ActIV) has been investigated by NMR spectroscopy and molecular mechanics. The spatial structures of the complexes between the drugs and a model deoxytetranucleotide, 5'-d(TpGpCpA), have been determined by molecular mechanics methods using homonuclear (1)H-(1)H 2D-NOESY and heteronuclear (1)H-(31)P (HMBC) NMR spectroscopic data. Observed intermolecular NOE contacts and equilibrium binding studies confirm that the binding affinity of the synthetic phenoxazone derivatives with d(TGCA) decreases with an increase in the number of CH(2) groups in the dimethylaminoalkyl side chains, i.e., ActII > ActIII > ActIV, in agreement with the observed biological activity of these compounds. Molecular mechanics calculations of the spatial structures of the intercalated complexes of ActII-ActIV with d(TGCA) indicate that the different binding constants of the phenoxazone derivatives with the DNA oligomer are due to the different degrees of intercalation of the chromophore and the different steric arrangements of aminoalkyl side chains in the minor groove of the tetramer duplex; this results in different distances between the negatively-charged phosphates of the DNA duplex and the terminal positively-charged N(CH(3))(2) groups of the side chains.

[Dependence of mode of DNA binding to benzo crown derivatives of actinocin on the size and distance from the chromophore of crown fragments]. / Issledovanie zavisimosti sposoba sviazyvaniia s DNK benzokraunsoderzhashchikh proizvodnykh aktinotsina ot razmera i udalennosti ot khromofora kraun-gruppirovok.

Complexes of DNA with benzocrown derivatives of actinocin were studied by viscometry and dynamic birefringence. Changes in the macromolecular structure of DNA caused by complex formation were determined. Models of DNA binding to the studied compounds were suggested on the basis of data obtained. The intercalation of actinocin chromophore of benzocrown derivatives of actinocin was shown to occur only when benzocrown groups were bound to the chromophore via glycine fragment. A change in the distance between the crown group and the chromophore prevents ligand intercalation. Increase in medium ionic strength results in appearance of new nonintercalational binding mode for crown-containing compounds with DNA caused by interaction of the crown groups with DNA.