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Am J Vet Res ; 54(12): 2088-90, 1993 Dec.
Article in English | MEDLINE | ID: mdl-8116943

ABSTRACT

To evaluate the effect of ketoprofen on fecal output during secretory diarrhea, 16 calves were given approximately 200 micrograms of heat-stable Escherichia coli enterotoxin by suckling on 2 occasions. On one day, treatment was not administered. On the other day, either 3 mg of ketoprofen/kg of body weight (n = 8) or 6 mg of ketoprofen/kg (n = 8) was administered 1 hour before and 3 hours after administration of enterotoxin. Fecal output was no different after 8 or 24 hours from calves given 3 mg/kg, but fecal output was less at 8 hours and 24 hours for calves given 6 mg/kg (P = 0.0588), compared with the control day.


Subject(s)
Bacterial Toxins/toxicity , Diarrhea/drug therapy , Enterotoxins/toxicity , Ketoprofen/therapeutic use , Animals , Cattle , Dose-Response Relationship, Drug , Drug Administration Schedule , Escherichia coli Proteins , Feces , Male
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