ABSTRACT
The examination of 404 patients with periodic disease (301 with uncomplicated form and 104 with amyloidosis complication) has detected decreased functional activity of T-lymphocytes and their suppressor subpopulation, their subnormal quantity. There was a rise in T-helper/T-suppressor index, level of B- and 0-lymphocytes, sensitivity to the renal antigen. Colchicin therapy stopped the attacks and stimulated T-suppressor activity. Combined treatment with tactivin is proposed.
Subject(s)
B-Lymphocytes/immunology , Familial Mediterranean Fever/immunology , Familial Mediterranean Fever/physiopathology , T-Lymphocytes/immunology , Adolescent , Adult , Female , Humans , Male , Middle AgedABSTRACT
AIM: To specify immune changes in periodical disease (PD) in different periods of PD development as well as peculiarities of their changes in colchicin therapy. MATERIAL AND METHODS: Clinicoimmunological investigations including blast transformation of lymphocytes with lymphocytic mitogen and renal antigen, leukocyte migration inhibition with renal antigen, spontaneous and complementary rossette formation were made in 828 PD patients and 43 donors. RESULTS: Decreased functional activity and quantity of T-lymphocytes, their suppressory subpopulation was found in PD. The indices did not correlate with the disease variants and gender but with age and PD complication. In amyloidosis immunological indices deteriorate with positive trend after colchicin treatment. CONCLUSION: PD is characterized by strain in immunological process.
Subject(s)
Familial Mediterranean Fever/immunology , Lymphocyte Activation/immunology , T-Lymphocytes/immunology , Adolescent , Adult , Colchicine/therapeutic use , Disease Progression , Familial Mediterranean Fever/drug therapy , Female , Gout Suppressants/therapeutic use , Humans , Immunity, Cellular/drug effects , Immunity, Cellular/immunology , Lymphocyte Activation/drug effects , Male , Middle Aged , Prognosis , T-Lymphocytes/drug effectsABSTRACT
The paper is concerned with investigation of the nature of ultrastructural alterations in Entamoeba moshkovski under the levorin effect. The studies showed that under the effect of levorin there appeared in the Entamoeba cultures diverse types of cells having chiefly the following ultrastructural alterations: a higher number and size of cytoplasmic vacuoles, lower density of the cytoplasm granular component, not intact nuclear and plasmatic membranes and cell cytolysis. Analysis of the experimental results suggested that the amebicidal effect of levorin on Entamoeba was mainly associated with its membranotropic properties.
Subject(s)
Antifungal Agents/pharmacology , Candicidin/pharmacology , Entamoeba/drug effects , Animals , Cell Membrane/drug effects , Cell Membrane/ultrastructure , Cytoplasm/drug effects , Cytoplasm/ultrastructure , Dose-Response Relationship, Drug , Entamoeba/ultrastructure , Microscopy, Electron/methods , Time FactorsABSTRACT
All-Union Research technological Institute of Antibiotics and Medical Enzymes, Leningrad. Institute of Epidemiology, Virology and medical parasitology, Ministry of Health of the Armenian SSR. The effect of polyenic antibiotics made in the USSR on development of E. histolytica and E. moshkovski was studied. The following antibiotics were used: levorin and its derivatives, mycoheptin, amphotericin B, amphoglucamine and nystatin. The antibiotics were compared with emetine and metronidazole. Some drugs of the imidazole group were also included into the study. On the whole 15 drugs were tested for their antiamebic activity. All the polyenic antibiotics showed a high antiamebic activity. Levorin and its derivatives were the most active. Their MICs ranged from 0.1 to 5.38 micrograms/ml. The most active of the new imidazoles was 100 times less effective than sodium levorin. The studies show that the polyenic antibiotics have an antiamebic activity and a broad antiprotozoal spectrum.
