ABSTRACT
The effectiveness of immunodepressants in lingering exudative processes, their inhibitory action in the proliferative phase of inflammation, depression of the phagocytic activity of leucocytes, as well as suppressive influence on the development of a toxic pulmonary edema and upon generalized anaphylaction reaction was demonstrated in tests staged on rats and mice. The antiphlogistic action of immunodepressants was not abolished during the first hours after their administration by specific metabolites, but was suppressed at the peak of the cytostatic effect together with the latter. The phlogolytic effect was not mediated through the hypophysis-adrenal system and did not include the lienic factor.
Subject(s)
Anti-Inflammatory Agents , Immunosuppressive Agents/therapeutic use , Anaphylaxis/drug therapy , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug Therapy, Combination , Fluorouracil/therapeutic use , Granuloma/drug therapy , Mercaptopurine/therapeutic use , Methotrexate/therapeutic use , Phagocytosis/drug effects , Pulmonary Edema/drug therapy , Rats , Time FactorsABSTRACT
As evidenced from experiments conducted on rats immunodepressants-antimetabolites 6-mercaptopurine, methotrexate and 5-fluoruracil exert an antiexudative action and inhibit inflammation in its proliferative phase, as well as significantly change the count of leucocytes and their formula in the peripheral blood. It was established that the anti-exudate properties of these compounds may not be related to their immunodepressive action, while inhibition of proliferation is occasioned by their specific cytostatic effect.
