Subject(s)
Plants, Medicinal/analysis , Trypanocidal Agents , Administration, Oral , Animals , Female , Injections, Intramuscular , Injections, Intravenous , Male , Nigeria , Plant Extracts/administration & dosage , Plant Extracts/pharmacology , Rats , Rats, Inbred Strains , Trypanosoma brucei brucei/drug effects , Trypanosoma brucei gambiense/drug effects , Trypanosomiasis, African/drug therapy , Trypanosomiasis, African/parasitologyABSTRACT
Two new compounds, ethyl N-succinimidoxyacetate and methyl N-succinimidoxyacetate, were prepared by reacting a solution of freshly recrystallized N-hydroxysuccinimide in tetrahydrofuran with a mixture of the corresponding halogenated ester and triethylamine. The compounds possessed some anticonvulsant properties.
Subject(s)
Anticonvulsants/chemical synthesis , Succinimides/chemical synthesis , Animals , Chickens , Succinimides/pharmacologyABSTRACT
Since 19-iodocholesterol ethyl and methyl ethers and 3 beta-iodo-5-cholestene localized in dog adrenal, the distribution of 19-iodocholesterol 3-acetate was similarly studied. This ester was concentrated by the dog adrenal to the same extent as 19-iodocholesterol. Despite a previous report that the ester was not appreciably taken up by the rat adrenals, distribution experiments were undertaken, and the results showed that the ester preferentially localized in the adrenals of the rat as well as the dog.
Subject(s)
19-Iodocholesterol/analogs & derivatives , Adrenal Glands/metabolism , Cholesterol/analogs & derivatives , 19-Iodocholesterol/metabolism , Animals , Dogs , Rats , Rats, Inbred Strains , Species Specificity , Tissue DistributionABSTRACT
19-Iodocholesterol-131I, though useful as an adrenal scanning agent, was found to be unstable. However, the substitution of methoxyl and ethoxyl groups for the hydroxyl group in the 3 position rendered these derivatives much more stable in solid form than the parent compound. They showed concentration in the adrenals of dogs similar to that of 19-iodocholesterol itself and therefore may be useful as adrenal scanning agents.
