High Intensity Focused Ultrasound Treatment for Uterine Fibroid in a Nigerian Hospital: A Case Report and Review of Literature.

High intensity focused ultrasound (HIFU) is a non-invasive method of treating uterine fibroid that is based on the principle of using extracorporeal ultrasound to cause coagulative necrosis of uterine fibroid. While the technology has been used in other parts of the world, it is new in West Africa. The reported case was the first HIFU treatment of uterine fibroid in Nigeria. A 38-year-old woman was prepared for HIFU treatment of uterine fibroid. Abdomino-pelvic ultrasound scan, Magnetic Resonance Imaging (MRI) and pre-procedural bowel preparation were done. High intensity focused ultrasound (JC200) treatment was done under conscious sedation using average power of 400 Watts with total energy consumption of 278.0 Kilo Joules with total sonication time of 700 seconds. The patient was able to resume her daily activities one week post-HIFU procedure.

Ultrasons focalisés de haute intensité (HIFU)est une méthode non invasive de traitement des fibromes utérins à base sur le principe de l'utilisation d'ultrasons extracorporels pour provoquer nécrose coagulative du fibrome utérin. Alors que la technologie a été utilisé dans d'autres parties du monde, il est nouveau en Occident Afrique. Le cas signalé était le premier traitement HIFU de l'utérus fibrome au Nigeria. Une femme de 38 ans était préparée pour HIFU traitement du fibrome utérin. Échographie abdomino-pelvienne, Imagerie par résonance magnétique (IRM) et intestin pré-procéduralla préparation a été faite. Ultrasons focalisés de haute intensité (JC200) le traitement a été effectué sous sédation consciente en utilisant puissance moyenne de 400 Watts avec une consommation totale d'énergie de278,0 kilojoules avec un temps de sonication total de 700 secondes. Le patiente a pu reprendre ses activités quotidiennes une semaine après la procédure de HIFU.

Drivers of anthropogenic air emissions in Nigeria - A review.

This study presents a review of sources and atmospheric levels of anthropogenic air emissions in Nigeria with a view to reviewing the existence or otherwise of national coordination aimed at mitigating the continued increase. According to individual researcher's reports, the atmospheric loading of anthropogenic air pollutants is currently on an alarming increase in Nigeria. Greater concerns are premised on the inadequacy existing emission inventories, continuous assessment, political will and development of policy plans for effective mitigation of these pollutants. The identified key drivers of these emissions include gas flaring, petroleum product refining, thermal plants for electricity generation, transportation, manufacturing sector, land use changes, proliferation of small and medium enterprises, medical wastes incineration, municipal waste disposal, domestic cooking, bush burning and agricultural activities such as land cultivation and animal rearing. Having identified the key sources of anthropogenic air emissions and established the rise in their atmospheric levels through aggregation of literature reports, this study calls for a review of energy policy, adoption of best practices in the management air emissions and solid wastes as well as agriculture and land use pattern which appear to be the rallying points of all identified sources of emission. The study concluded that the adoption of cleaner energy policies and initiatives in energy generation and usage as against pursuit of thermal plants and heavy dependence on fossil fuels will assist to ameliorate the atmospheric loadings of these pollutants.

Effect of irrigation on soil health: a case study of the Ikere irrigation project in Oyo State, southwest Nigeria.

Irrigated agriculture is one of the significant contributors to the food security of the millennium development goals (MDGs); however, the modification of soil matrix by irrigation could alter the overall soil health due to changes in soil properties and processes. The objective of the study was to evaluate the effect of irrigation on soil quality status of the Ikere center pivot irrigation project site in Oyo State, southwest Nigeria. Disturbed soil samples were collected from 0 to 30, 30 to 60, and 60 to 90-cm layers from four different sites in three replicates, within the project location for the determination of soil bio-chemical properties. The average values of sodium adsorption ratio (SAR) < 13, electrical conductivity (EC) <4 µS/cm, and pH < 8.5 showed that the soil condition is normal in relation to salinity and sodicity hazards. The effective cation exchange capacity (ECEC), soil organic matter (SOM), total nitrogen (TN), and calcium ion (Ca2+) concentrations were low while the available phosphorus (P) was moderate. The principal component analysis showed EC, ECEC, SAR, SOM, and TN as the minimum data set (MDS) for monitoring and assessing the soil quality status of this irrigation field. In terms of bio-chemical properties, the soil quality index (SQI) of the field was average (about 0.543) while the sampling locations were ranked as site 2 > site 4 > site 3 > site 1 in terms of SQI. The results of this study are designated as baseline for future evaluation of soil quality status of this irrigation field and further studies should incorporate soil physical and more biological properties when considering overall soil quality status.

Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria.

BACKGROUND: Infertility is a major problem in sickle cell disease patients, especially in males. In addition to low serum testosterone, other abnormalities involving the accessory sex organs, such as the seminal vesicles and the prostate gland, as well as marked decrease in ejaculate volume may be observed in male HbSS patients. Hence, the need to study the role of sex hormones as a cause of infertility in male HbSS patients. METHODS: An unmatched case-control study was performed using seventy-five consenting subjects from Lagos University Teaching Hospital. These included 47 patients with haemoglobin phenotype SS from the Sickle cell clinic and 28 volunteered medical students and members of staff with haemoglobin phenotype AA. Demographic data were obtained using a self-administered questionnaire. A total of 5 mls of blood was collected from each subject between 9.00 am & 11.am, and assayed for serum testosterone concentration. RESULTS: The concentrations of serum testosterone in HbSS patients ranged from 0.2 to 4.3 ng/ml with a mean of 1.28 ± 0.72 ng/ml whilst the values in HbAA controls ranged from 1.2 to 6.9 ng/ml with a mean of 2.63 ± 1.04 ng/ml. Seven (25.0%) of the 28 controls had serum testosterone concentration lower than the quoted reference (normal) range whereas 44 (93.6%) of the 47 HbSS subjects had serum testosterone concentration lower than the reference range. CONCLUSION: Overall, subjects with HbSS have significantly lower mean serum testosterone than HbAA controls.

Kidney function of HIV-infected children in Lagos, Nigeria: using Filler's serum cystatin C-based formula.

BACKGROUND: Limited data is available on kidney function in HIV-infected children in sub-Saharan Africa. In addition, malnutrition in these children further reduces the utility of diagnostic methods such as creatinine-based estimates of glomerular filtration rate. We determined the serum cystatin C level and estimated glomerular filtration rate of 60 antiretroviral-naïve, HIV-infected children and 60 apparently healthy age and sex matched children. METHODS: Serum cystatin C level was measured using enzyme-linked immunosorbent assay technique, while glomerular filtration rate was estimated using Filler's serum cystatin C formula. Student t test, Mann Whitney U test, Pearson chi square and Fisher's exact test were used, where appropriate, to test difference between groups. RESULTS: Compared to the controls, the HIV-infected group had significantly higher median (interquartile range) serum cystatin C levels {0.77 (0.29) mg/l versus 0.66 (0.20) mg/l; p = 0.025} and a higher proportion of children with serum cystatin C level >1 mg/l {10 (16.7%) versus one (1.7%); p = 0.004}. The HIV-infected children had a mean (+/- SD) eGFR of 96.8 (+/- 36.1) ml/min/1.73 m2 compared with 110.5 (+/- 27.8) ml/min/1.73 m2 in the controls (p = 0.021). After controlling for age, sex and body mass index, only the study group (HIV infected versus control) remained a significant predictor of serum cystatin C level (beta = -0.216, p = 0.021). The proportion of HIV-infected children with eGFR <60 ml/min/1.73 m2 was eight (13.3%) versus none (0%) in the control group (p = 0.006). However, the serum cystatin C level, eGFR and proportions of children with serum cystatin C level >1 mg/l and eGFR <60 ml/min/1.73 m2 were not significantly different between the HIV-infected children with advanced disease and those with milder disease. CONCLUSIONS: HIV-infected children in Nigeria have higher serum cystatin C level and lower eGFR compared to age and sex matched controls.