ABSTRACT
Psoriasis is a common inflammatory disease that has a severe impact on quality of life. There is lack of data regarding epidemiological and clinical features of psoriasis patients in Turkey, a country with a population of 76 million. The aim of this study was to define the demographic and clinical characteristics, quality of life and treatment patterns of psoriasis patients in Turkey. A cross-sectional observational study was conducted at 40 centers, chosen from geographically diverse locations in Turkey. Patients diagnosed with psoriasis were assessed by investigators who were specialists of dermatology using standardized study questionnaire forms. Dermatology Life Quality Index (DLQI) and EuroQol-5 dimension (EQ-5D) forms were also filled out by each patient. 3971 psoriasis patients were included in this study. 24.2% of plaque psoriasis patients had moderate to severe psoriasis (Psoriasis Area and Severity Index, ≥10). Mean DLQI was 7.03 ± 6.02; quality of life was moderately, severely or very severely affected in 49.2% of patients. The most severely affected component of EQ-5D was anxiety/depression. Among all patients, 22.9% were not receiving any treatment, 39.8% were receiving only topical treatment, 11.5% were on phototherapy, 26.1%, were taking conventional systemic agents and 4.1% were on a biologic treatment. 31.3% of psoriasis patients with moderate to severe disease were treated with only topical agents and only 30.5% of moderate to severe psoriasis patients were receiving systemic therapy. Moderate to severe psoriasis has a considerable impact on quality of life. Treatment in Turkey of patients with moderate to severe psoriasis is insufficient.
Subject(s)
Psoriasis/therapy , Adolescent , Adult , Anxiety/etiology , Biological Products/therapeutic use , Cross-Sectional Studies , Dermatologic Agents/administration & dosage , Female , Humans , Male , Middle Aged , Phototherapy , Psoriasis/pathology , Psoriasis/psychology , Quality of Life , Turkey , Young AdultSubject(s)
Chlorides/adverse effects , Chromium Compounds/adverse effects , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/etiology , Dietary Supplements/adverse effects , Adrenal Cortex Hormones/therapeutic use , Adult , Chlorides/administration & dosage , Chromium Compounds/administration & dosage , Dermatitis, Allergic Contact/drug therapy , Humans , Male , Minerals/administration & dosage , Vitamins/administration & dosageABSTRACT
A 29-year-old Turkish woman with allergic contact cheilitis from a lipstick was misdiagnosed as herpes labialis and subsequently worsened with the application of Zovirax cream. Patch tests were positive to Zovirax cream, propylene glycol, the patient's favourite lipstick and propyl gallate. No reaction was seen with Zovirax ophthalmic ointment and Zovirax tablet. The propylene glycol component of the Zovirax cream and the propyl gallate component of the lipstick were regarded as the responsible contact sensitizers. The differential diagnosis was challenging due to concomitant contact sensitization with these agents.
Subject(s)
Acyclovir/adverse effects , Antiviral Agents/adverse effects , Cheilitis/diagnosis , Cosmetics/adverse effects , Dermatitis, Allergic Contact/diagnosis , Diagnostic Errors , Herpes Labialis/diagnosis , Adult , Cheilitis/chemically induced , Dermatitis, Allergic Contact/etiology , Female , Herpes Labialis/drug therapy , HumansABSTRACT
We report a case of a 7-year-old girl with hyperimmunoglobulin-E syndrome presenting with widespread oral papillomas which were tested for human papilloma virus DNA and had shown to be at high/intermediate risk group for malignancy. She had elevated levels of IgE, recurrent sinopulmonary infections, atopic-like dermatitis, peripheral eosinophilia and defective neutrophil chemotaxis. Interferon alfa 2b therapy and chemoprophylaxis with sulfamethoxazole-trimethoprim was given. Although the papillomas partially improved with the treatment, sinopulmonary infections continue to occur.