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1.
Fr J Urol ; : 102670, 2024 Jun 21.
Article in English | MEDLINE | ID: mdl-38909783

ABSTRACT

INTRODUCTION: Internal urethrotomy (IU) has been the most commonly used procedure for the treatment of urethral strictures (US) since it was described by Scahse in 1974. Although simple to perform and associated with a short recovery time, the main disadvantage is the high recurrence rate of stenosis. At present, there are no markers available for the prediction of recurrence after IU. The aim of this study was to evaluate the correlation between MHR and recurrence rates. METHODS: The data of a total of 250 male patients who underwent IU for the first time for bulbar urethral stricture less than 2 cm in our hospital between January 2011 and January 2019 were retrospectively analysed. The MHR was calculated as the ratio of monocytes to HDL-C. RESULTS: 78 patients experienced a recurrence while the remaining 177 did not. The stricture recurrence rate was recorded as 31.2 % at the 3-year follow-up. There was a statistically significant difference in stricture length and MHR (p=0.015 and 0.001 respectively). MHR was high in the recurrent group. As a result of the Chi-square test, the positive predictive values (PPV) and negative predictive values (NPV) were 65.3 % and 89.7 %, respectively. ROC analysis was used to determine the optimal cut-off value. The cut-off value was found to be 1.72. CONCLUSION: In our opinion, a high MHR may indicate the presence of immune inflammation, and it can be used as a prognostic factor for stricture recurrence after IU.

2.
J Laparoendosc Adv Surg Tech A ; 34(5): 420-424, 2024 May.
Article in English | MEDLINE | ID: mdl-38546503

ABSTRACT

Backgrounds: In the renal intrarenal stone surgery (RIRS) procedure, ureteral access sheath (UAS) is still used in the majority of surgeries to both protect the flexible ureteroscope (FURS) and reduce intrarenal pressure. ClearPETRA is a new UAS that has an integrated aspiration port. We aimed to evaluate the clinical outcomes and effectiveness of Aspiration-Assisted UAS (ClearPETRA) in the RIRS procedure. Methods: One thousand six hundred twenty patients who underwent RIRS between January 2021 and January 2024 were evaluated retrospectively and 512 patients were included in the study. According to stone size, patients with stones less than 2 cm and those with stones between 2 and 3 cm were analyzed separately. Patient's demographic data, stone size, body mass index, Extracoporeal Shockwave Lithotripsy (ESWL) history, stone side, stone density (Hounsfield Unit), operation time, stone-free rate (SFR), and the number of patients with sepsis were recorded. SFR was evaluated with kidney urinary bladder 3 months after surgery for opaque calculi. Nonopaque calculi patients were evaluated with noncontrast computed tomography 3 months after surgery. In the postoperative evaluation, patients with stones less than 4 mm were evaluated as SFR. P value of <0.01 was considered statistically significant. Results: Patient's demographic data, stone characteristics, and history of ESWL were similar in the ClearPETRA and UAS groups (P > .05). A total of 328 patients who underwent RIRS for stones less than 2 cm were included (80 ClearPETRA, 248 UAS). Length of hospital stay, operation time, SFR, secondary intervention, or postoperative sepsis (P ≥ .01) were similar in both groups. The incidence of postoperative fever was statistically significantly lower in the ClearPETRA group (P = .006). A total of 184 patients who underwent RIRS for stones between 2 and 3 cm were included (42 ClearPETRA, 142 UAS). In the ClearPETRA group, operation time was statistically significantly shorter (P = .002), SFR was statistically significantly higher (P = .003), and the number of fever and sepsis were statistically significantly less (P = .003 and 0.002, respectively). Conclusion: We found that ClearPETRA reduces the likelihood of postoperative fever after RIRS surgeries. Moreover, we can say that the use of ClearPETRA in RIRS, especially for stones larger than 2 cm, reduces the operation time, increases the SFR, and also reduces sepsis rates.


Subject(s)
Kidney Calculi , Humans , Male , Female , Retrospective Studies , Kidney Calculi/surgery , Middle Aged , Adult , Treatment Outcome , Ureter/surgery , Suction/methods , Operative Time , Aged , Ureteroscopes , Ureteroscopy/methods , Equipment Design
3.
North Clin Istanb ; 11(1): 18-26, 2024.
Article in English | MEDLINE | ID: mdl-38357314

ABSTRACT

OBJECTIVE: The aim of the study is to investigate the validity and reliability of the "Telemedicine Awareness, Knowledge, Attitude, and Skills (AKAS) of Telemedicine" questionnaire and to convert the questionnaire to Turkish. METHODS: The study is methodological research conducted among medical faculty students and medical residents. For the validity and reliability analysis of the "AKAS of Telemedicine" questionnaire, 425 medical faculty students and medical residents were included in the study, and the sample was 7-10 times the number of questionnaire items. Exploratory factor analysis was performed for construct validity. The test-retest method was engaged to assess reliability. Cronbach's alpha reliability coefficient and the item-total correlation coefficient were calculated for internal consistency. Descriptive statistics were given as mean, standard deviation, median, and first and third quartile values for numerical variables, and numbers and percentages for categorical variables. The Mann-Whitney U test, the Kruskal-Wallis test, and Spearman's correlation coefficient were conducted to evaluate the correlation between variables. RESULTS: The Cronbach alpha reliability coefficient of the "AKAS of Telemedicine" questionnaire was found to be 0.950, 0.851, 0.970, and 0.952 in the sub-areas, respectively. When an item was removed, the Cronbach alpha reliability coefficient values ranged between 0.826 and 0.969, and no significant difference was detected. As a result of test-retest reliability analysis, a strong positive correlation was found between the total scores (awareness r=0.848, knowledge r=0.792, attitude r=0.787, and skill r=0.816; p<0.001 for each score). CONCLUSION: The Turkish form of the "AKAS of Telemedicine" questionnaire is a valid and reliable measurement tool that can be used to evaluate the level of AKAS among physicians. It was concluded that research using the "AKAS of Telemedicine" questionnaire would be useful to determine the telemedicine AKAS levels among Turkiye, particularly in health sector workers.

4.
Urol Int ; 108(3): 226-233, 2024.
Article in English | MEDLINE | ID: mdl-38368856

ABSTRACT

INTRODUCTION: The main challenge to the optimal use of neoadjuvant chemotherapy (NAC) is the difficulty in selecting patients who may or may not benefit from NAC. Our aim in this study was to investigate whether the Systemic Inflammatory Index (SII) predicts response to chemotherapy in patients who receive NAC prior to cystectomy. METHODS: We retrospectively analysed the data of patients who underwent NAC followed by cystectomy at our institution between January 2010 and September 2015 and whose 5-year follow-up was completed. All patients who underwent diagnostic biopsy with complete transurethral resection of bladder tumour at our hospital and whose pathology result was muscle-invasive transitional cell carcinoma were included in the study. At least 3 courses of gemcitabine/cisplatin NAC were given to all patients. A pathological response was defined as a reduction in cystectomy to a lower pathological stage after NAC. RESULTS: The SII was 320.8 ± 51 in the responders and 388.28 ± 50 in the non-responders. SII optimal cut-off of 350 was determined. The sensitivity and specificity of SII in predicting response were found to be 80% and 83%, respectively. Low SII (<350) was found to be a significant predictor of response compared with the other factors on multivariate analysis. The mean overall survival time was 55.4 months in patients with a low SII value and 40.3 months in the high SII group. CONCLUSION: SII, together with known clinicopathological factors and newer genetic and molecular markers, can be used to select patients for NAC.


Subject(s)
Carcinoma, Transitional Cell , Cystectomy , Neoadjuvant Therapy , Urinary Bladder Neoplasms , Humans , Urinary Bladder Neoplasms/drug therapy , Urinary Bladder Neoplasms/surgery , Urinary Bladder Neoplasms/pathology , Cystectomy/methods , Male , Retrospective Studies , Female , Aged , Middle Aged , Carcinoma, Transitional Cell/drug therapy , Carcinoma, Transitional Cell/surgery , Carcinoma, Transitional Cell/pathology , Carcinoma, Transitional Cell/therapy , Treatment Outcome , Inflammation , Chemotherapy, Adjuvant , Predictive Value of Tests , Gemcitabine , Cisplatin/therapeutic use , Cisplatin/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Deoxycytidine/analogs & derivatives , Deoxycytidine/therapeutic use , Deoxycytidine/administration & dosage
5.
J Coll Physicians Surg Pak ; 33(11): 1278-1282, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37926881

ABSTRACT

OBJECTIVE: To investigate active surveillance (AS) for patients with prostate cancer to show the systemic inflammatory index (SII) progression and to evaluate whether SII will be an AS criterion in PCa patients. STUDY DESIGN: Descriptive study. Place and Duration of the Study: Department of Urology, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital, from February 2015 to December 2021. METHODOLOGY: For active surveillance follow-up criteria, patients with prostate cancer who underwent AS with PSA <10 ng/ml, GS ≤6, clinical stage t1c-t2b, ≤2 core positive, and for each positive core had ≤50% tumour cells, were inducted and SII was determined. RESULTS: As a result of the univariate analysis, high SII values, number of cores involved, and length of the tumour in one core significantly affected progression (in order of p = 0.009, B = 1.830, Exp(B) = 6.233, CI [1.58-24.497]; p = 0.018, B = 0.682, Exp(B) = 1.978, CI [1.123-3.482]; p=0.006, B = 1.835, Exp(B) = 6.263 CI [1.692-23.181]). High SII values (>443.42) had better explanations for progression than the number of core involvement but were similar to the length of the tumour in one core. As a result of the multivariate analysis, high SII values (>443.42) and the tumour 's length in one core had similar effects on progression (in order of p = 0.011, B = 1.978, Exp(B) = 7.227, CI [1.570-33.269]; p = 0.009, B = 1.958, Exp(B) = 7.084, CI [1.642-30.555]). CONCLUSION: Th use of SII early in the course of treatment can help to identify which prostate cancer patients can be selected for active treatment instead of active surveillance, and to assess the probability of progression. KEY WORDS: Prostate cancer, Active surveillance, Systemic inflammatory index, Biomarker.


Subject(s)
Prostatic Neoplasms , Watchful Waiting , Male , Humans , Prostatic Neoplasms/therapy , Prostatic Neoplasms/pathology , Prostate-Specific Antigen , Biomarkers , Multivariate Analysis
6.
BMC Urol ; 23(1): 197, 2023 Nov 29.
Article in English | MEDLINE | ID: mdl-38031043

ABSTRACT

BACKGROUND: Although PCNL has been used for a long time to treat nephrolithiasis, there is still contradictory information concerning the use of the dilation method. In this study, we aimed to compare conventional sequential Amplatz dilatation (SAD) using ten dilators and a method using three dilators (12, 20, and 30 Fr), which we named "three-shot dilatation" (3SD), in terms of fluoroscopy time (FT), operation time, bleeding and stone-free rates. METHODS: The study included patients who underwent PCNL with the SAD and 3SD methods. A different surgeon with extensive endourology experience applied each technique. One of the surgeons operated on the patients using the SAD method with ten dilators, and the other surgeon performed the operations using the 3SD method involving three Amplatz dilators (12, 20, and 30 Fr). RESULTS: A total of 283 patients, 138 in the 3SD group and 145 in the SAD group, were included in the study. The mean age of the patients was 47.32 ± 13.71 years. There was no statistically significant difference between the two groups regarding preoperative characteristics (p > 0.05). The FTs of access 2, total access, and total operation were significantly shorter in the 3SD group (p = 0.0001). The decrease in hemoglobin was statistically significant in the 3SD group compared to the SAD group (p = 0.022), while the blood transfusion requirements of the groups were similar (p = 0.176). There was no statistically significant difference between the two groups regarding stone-free rates (p = 0.973). In four patients in the SAD group, re-access was necessary due to the loss of passage due to the guide wire slipping out of its place. CONCLUSION: Intraoperative FT can be shortened using the described 3SD method without compromising surgical safety. However, this method can be used as an intermediate step in the transition to one-shot dilation by surgeons experienced in performing SAD.


Subject(s)
Kidney Calculi , Nephrostomy, Percutaneous , Humans , Adult , Middle Aged , Nephrostomy, Percutaneous/methods , Dilatation/methods , Kidney Calculi/diagnostic imaging , Kidney Calculi/surgery , Fluoroscopy , Hemorrhage , Treatment Outcome
7.
Prog Urol ; 33(15-16): 1008-1013, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37758608

ABSTRACT

AIM: We aimed to determine the effectiveness of penis-root masturbation (PRM), a newly defined behavioral therapy (BT) technique, in patients with unsuccessful medical treatment due to premature ejaculation (PE). MATERIAL AND METHODS: The study included 35 patients aged 25-43 years, who were diagnosed with lifelong PE. Patients and their partners were informed about the PRM technique and asked to practice PRM three times a week for three months, with or without sexual intercourse. The patients' Premature Ejaculation Diagnostic Tool (PEDT) scores and intravaginal ejaculatory latency time (IELT) were recorded and compared before PRM training (T0) and at the third (T3) month after the start of PRM training. RESULTS: The mean±SD PEDT scores were 16.26±1.94 at T0, 10.63±1.14 at T3. When compared to T0, the PEDT values at T3 were significantly lower (P=0.021). In terms of IELT, the mean T3 values (192.43±56.71) were significantly longer (P=0.035) than at T0 (50.43±13.84seconds). CONCLUSION: PRM BT shows promise for lifelong PE patients who do not benefit from or discontinue to pharmacotherapy. Larger prospective trials are required to confirm these findings.


Subject(s)
Premature Ejaculation , Male , Humans , Premature Ejaculation/therapy , Masturbation , Prospective Studies , Ejaculation , Behavior Therapy
8.
Chem Commun (Camb) ; 59(38): 5741-5744, 2023 May 09.
Article in English | MEDLINE | ID: mdl-37092602

ABSTRACT

Nanotube-structured TiO2 electrodes on Ti plates were formed in ethylene glycol solution by the anodic oxidation method applied for different times and calcined at 500 °C. Different amounts of WO3 were decorated on the nanotube surfaces electrochemically. The electrodes were characterized, and the effects of the nanotube length on the Ti plate, decorated WO3 amount, electrolyte concentration, applied potential, and type of radiation source on the oxidation of 3-methylpyridine were investigated, together with the product distribution/selectivity. In a photoelectrocatalytic system, the vitamin B3 yield increased significantly (ca. 17 fold) under UVA by decorating nanotube-structured TiO2 with WO3, whilst low reaction rates and no products were found under Vis irradiation, as only unselective photolytic reactions occurred. This unexpected result was clarified for the first time in the literature.

9.
Andrologia ; 54(11): e14601, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36146889

ABSTRACT

Mean platelet volume (MPV) has been related to erectile dysfunction (ED). However, its value in predicting therapeutic response to phosphodiesterase-5 inhibitors is not evaluated. This study aimed to investigate the value of MPV as a marker for the prediction of the response of the tadalafil treatment of ED. A retrospective analysis of patients who were admitted to the andrology outpatient clinic between 2020-2022 were performed. The inclusion criteria were, ≥40 years old male, International Index of Erectile Function-Erectile Function domain score < 26, not received any ED treatment before, have a stable heterosexual relationship, and prescribed 5 mg daily tadalafil for primary treatment of ED. A total of 116 patients were included in the study. The mean age of the patients was 53.7 ± 8.7 years. The response rate to 5 mg tadalafil treatment was 52.6% (Group-1; N = 61). An MPV value 3 10.05 fL was associated with 66% sensitivity and 75,4% specificity for no response to 5 mg daily tadalafil treatment (Area under curve = 76.9% [95% CI 68.2%-85.6%; p < 0.001]). Initial IIEF-EF score, fasting blood glucose, and MPV level was independently associated with the response to the tadalafil treatment. This is the only study to evaluate the value of MPV level on the therapeutic response of ED to tadalafil. Strict inclusion criteria were applied to the cohort. However, the diagnose of vascular ED has been made by clinical evaluation and retrospective design of the study were the limitations of the study. The results of our study suggest that MPV might be used to predict the result of 5 mg daily tadalafil treatment in selected ED patients as a fast and cost-effective test.


Subject(s)
Erectile Dysfunction , Humans , Male , Middle Aged , Adult , Tadalafil/therapeutic use , Retrospective Studies , Mean Platelet Volume , Carbolines/therapeutic use , Treatment Outcome , Double-Blind Method
10.
Front Chem ; 10: 856947, 2022.
Article in English | MEDLINE | ID: mdl-35646812

ABSTRACT

Nanotube/nanowire-structured TiO2 was formed on the Ti surface by an anodic oxidation method performed at different potential values (50 or 60 V) and for different times (3 or 5 h). The TiO2 photocatalysts were taken in powder form using the ultrasonic treatment from the Ti electrodes, calcined at different temperatures, and characterized by XRD and SEM techniques, and BET surface area analyses. Both the crystallinity and the size of the primary TiO2 particles increased by increasing the heat treatment temperature. While all the photocatalysts heat treated up to 500°C were only in the anatase phase, the particles heat-treated at 700°C consisted of both anatase and rutile phases. The BET specific surface area of the samples decreased drastically after heat treatment of 700°C because of partial sinterization. SEM analyses indicated that the prepared materials were structured in both nanotubes and nanowires. They were tested as photocatalysts for the selective oxidation of glycerol and 3-pyridinemethanol under UVA irradiation in water at room temperature and ambient pressure. Glyceraldehyde, 1,3-dihydroxyacetone, and formic acid were determined as products in glycerol oxidation, while the products of 3-pyridinemethanol oxidation were 3-pyridinemethanal and vitamin B3. Non-nanotube/nanowire-structured commercial (Degussa P25 and Merck TiO2) photocatalysts were used for the sake of comparison. Low selectivity values towards the products obtained by partial oxidation were determined for glycerol. On the contrary, higher selectivity values towards the products were obtained (total 3-pyridinemethanal and vitamin B3 selectivity up to ca. 90%) for the photocatalytic oxidation of 3-pyridinemethanol. TiO2 photocatalysts must be highly crystalline (calcined at 700°C) for effective oxidation of glycerol, while for the selective oxidation of 3-pyridinemethanol it was not necessary to obtain a high crystallinity, and the optimal heat treatment temperature was 250°C. Glycerol and its oxidation products could more easily desorb from highly crystalline and less hydroxylated surfaces, which would justifies their higher activity. The prepared photocatalysts showed lower activity than Degussa P25, but a greater selectivity towards the products found.

11.
Cent European J Urol ; 73(3): 349-354, 2020.
Article in English | MEDLINE | ID: mdl-33133664

ABSTRACT

INTRODUCTION: In this study we aimed to determine the effects of the 45 degrees sided prone position to the surgeon's comfort, operation time, fluoroscopy time and complications at the operation of percutaneous nephrolithotomy (PCNL) for the treatment of kidney stone of horseshoe kidney (HK) or rotation anomaly kidney. MATERIAL AND METHODS: Thirty eight patients (25 male, 13 female) with renal calculi and HK, underwent PCNL. After the amplatz sheath was inserted into the collecting system, the patients in group 1 (n:20) were taken to the 45 degrees side position to the side of the operation and patients in group 2 (n:18) were operated in classical prone position. Operative data of two groups were compared statistically. RESULTS: Mean stone size of group 1 was 557.8 ±244.8 mm3 (188-1175) and group 2 was 590.7 ±172.8 mm3 (423-909) (p = 0.639). In group 1 mean operation time was 78.6 ±21.8 (45-120) minutes and in group 2 was 95.05 ±11.5 (69-120) minutes. The difference for operation time was statistically significant and shorter in the sided group (p = 0.02). CONCLUSIONS: The working position of rigid nephroscope is 90 degrees to the body after the dorsomedial or dorsolateral access. In our study the position of patient is laterally sided 45 degree and the flexion on the surgeon's shoulder was minimised. This new position described for PCNL in HK allows comfortable working position for surgeon after upper pole posterior calyces access.

12.
Aging Male ; 23(5): 538-543, 2020 Dec.
Article in English | MEDLINE | ID: mdl-30463466

ABSTRACT

OBJECTIVE: To compare the efficacy of statins and ɑ blockers drug therapies for benign prostatic hyperplasia (BPH) in patients with metabolic syndrome (MetS). MATERIALS AND METHOD: A total of three hundred patients were randomly distributed into three groups of one hundred patients each. Group 1 received only ɑ-adrenoceptor antagonist (ɑ-blocker, AB) (Tamsulosin), group 2 received only statin (atorvastatin), and group 3 received AB plus statin (Tamsulosin + Atorvastatin). The efficacy measurement was assessed by analyzing the changes from baseline in the total International Prostate Symptom Score (IPSS), disease-specific QoL question score and maximum urinary flow rate at the end of 6 months in each group and between the three groups. RESULTS: Pre-treatment and post-treatment value of triglycerides (TG), high-density lipoprotein (HDL), and prostate volüme (PV) were not significantly different in AB group, while TG and PV were significantly lower in patients taking statin and combined therapy. The significant decrease was demonstrated in maximum urinary flow rate (Qmax) in three groups. However, the most significant decrease was observed in the combination therapy group. IPSS, postvoid residual urine volüme (PVR), and Quality of Life score (QoL) significantly changed in three groups. CONCLUSION: We recommend of the use of statins in those men with BPH accompanied by MetS in which AB is ineffective alone.


Subject(s)
Hydroxymethylglutaryl-CoA Reductase Inhibitors , Metabolic Syndrome , Prostatic Hyperplasia , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Male , Metabolic Syndrome/complications , Metabolic Syndrome/drug therapy , Prostatic Hyperplasia/complications , Prostatic Hyperplasia/drug therapy , Quality of Life , Sulfonamides , Treatment Outcome
13.
Int. braz. j. urol ; 44(6): 1243-1251, Nov.-Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-975668

ABSTRACT

ABSTRACT Introduction: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Materials and Methods: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and received no treatment. Rats in group 2 underwent a sham operation and received OPZ. Rats in group 3 underwent unilateral ureteral ligation and received no treatment. Group 4 rats were subjected to unilateral ureteral ligation plus OPZ administration. Transforming growth factor beta-1 (TGF-β1), E-cadherin, nitric oxide (NO) and hydroxyproline levels were measured. Histopathological and immunohistochemical examinations were carried out. Results: TGF-β1, NO and E-cadherin levels in the UUO group were significantly higher than the sham group and these values were significantly different in treated groups compared to the UUO group. In rats treated with UUO + OPZ, despite the presence of mild tubular degeneration and less severe tubular necrosis, glomeruli maintained a better morphology when compared to the UUO group. Expressions of α-SMA in immunohistochemistry showed that the staining positivity decreased in the tubules of the OPZ-treated group. Conclusions: While the precise mechanism of action remains unknown, our results demonstrated that OPZ exerted a protective role in the UUO-mediated renal fibrosis rat model highlighting a promising therapeutic potency of Nrf2-activators for alleviating the detrimental effects of unilateral obstruction in kidneys.


Subject(s)
Animals , Male , Rats , Pyrazines/therapeutic use , Ureteral Obstruction/complications , NF-E2-Related Factor 2/therapeutic use , Kidney Diseases/drug therapy , Thiones , Thiophenes , Ureteral Obstruction/pathology , Ureteral Obstruction/drug therapy , Fibrosis/etiology , Fibrosis/drug therapy , Immunohistochemistry , Cadherins/blood , Rats, Wistar , Disease Models, Animal , Transforming Growth Factor beta1/blood , Hydroxyproline/blood , Kidney Diseases/etiology , Kidney Diseases/pathology , Nitric Oxide/blood
14.
Materials (Basel) ; 11(9)2018 Sep 13.
Article in English | MEDLINE | ID: mdl-30217083

ABSTRACT

Nanotube structured TiO2 on Ti surface were prepared in ethylene glycol (Ti/TiO2NTEG) medium by anodic oxidation method with different times and then the plates were calcinated at different temperatures. Non-nanotube structured Ti/TiO2, prepared by thermal oxidation method, and nanotube structured TiO2 on Ti plate in hydrogen fluoride solution were also prepared for comparison. Pt loaded Ti/TiO2NTEG photoanodes were also prepared by cyclic voltammetry method with different cycles and the optimum loaded Pt amount was determined. Photoanodes were characterized by using X-ray Diffraction (XRD), Scanning Electron Microscopy-Energy-Dispersive X-ray Analysis (SEM-EDX), and photocurrent methods. XRD analyses proved that almost all TiO2 is in anatase phase. SEM analyses show that nanotubes and Pt nanoparticles on nanotube surface are dispersed quite homogeneously. The longest nanotubes were obtained in the ethylene glycol medium and the nanotube length increased by increasing applied anodic oxidation time. In addition, a linear correlation between nanotube length and XRD peak intensity was found. Moreover, SEM-EDX and XRD analyses evidence that Pt nanoparticles on nanotube surface are metallic and in cubic structure. Photoelectrocatalytic degradation of paraquat was performed using the prepared photoanodes. Moreover, electrocatalytic and photocatalytic degradations of paraquat were also investigated for comparison, however lower activities were observed. These results evidence that the photoanodes show a significant synergy for photoelectrocatalytic activity.

15.
Int Braz J Urol ; 44(6): 1243-1251, 2018.
Article in English | MEDLINE | ID: mdl-30130014

ABSTRACT

INTRODUCTION: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. MATERIALS AND METHODS: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and received no treatment. Rats in group 2 underwent a sham operation and received OPZ. Rats in group 3 underwent unilateral ureteral ligation and received no treatment. Group 4 rats were subjected to unilateral ureteral ligation plus OPZ administration. Transforming growth factor beta-1 (TGF-ß1), E-cadherin, nitric oxide (NO) and hydroxyproline levels were measured. Histopathological and immunohistochemical examinations were carried out. RESULTS: TGF-ß1, NO and E-cadherin levels in the UUO group were significantly higher than the sham group and these values were significantly different in treated groups compared to the UUO group. In rats treated with UUO + OPZ, despite the presence of mild tubular degeneration and less severe tubular necrosis, glomeruli maintained a better morphology when compared to the UUO group. Expressions of α-SMA in immunohistochemistry showed that the staining positivity decreased in the tubules of the OPZ-treated group. CONCLUSIONS: While the precise mechanism of action remains unknown, our results demonstrated that OPZ exerted a protective role in the UUO-mediated renal fibrosis rat model highlighting a promising therapeutic potency of Nrf2-activators for alleviating the detrimental effects of unilateral obstruction in kidneys.


Subject(s)
Kidney Diseases/drug therapy , NF-E2-Related Factor 2/therapeutic use , Pyrazines/therapeutic use , Ureteral Obstruction/complications , Animals , Cadherins/blood , Disease Models, Animal , Fibrosis/drug therapy , Fibrosis/etiology , Hydroxyproline/blood , Immunohistochemistry , Kidney Diseases/etiology , Kidney Diseases/pathology , Male , Nitric Oxide/blood , Rats , Rats, Wistar , Thiones , Thiophenes , Transforming Growth Factor beta1/blood , Ureteral Obstruction/drug therapy , Ureteral Obstruction/pathology
16.
Prostate Int ; 6(2): 71-74, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29922636

ABSTRACT

BACKGROUND: To investigate the effect of asymptomatic inflammatory prostatitis on clinical outcomes of patients undergoing trans urethral resection of prostate due to benign prostatic hyperplasia. MATERIALS AND METHODS: A total of 514 patients were enrolled in the study. Clinical parameters and pathological results were compared before and one year after surgery. RESULTS: Of the patients 310 were diagnosed with purely benign prostatic hyperplasia and the others were diagnosed with both prostatic inflamation (cathegory IV) and benign prostatic hyperplasia. No statistical significance was observed between two groups among the parameters including age, prostate volume and post voiding residue (P > 0.05). Patients with prostate inflammation presented higher preoperative International Prostate Symptom Score and lower Qmax values when compared to those without inflammation before trans urethral resection of prostate. CONCLUSION: Asymptomatic prostate inflammation can lead to worsen lower urinary tract symptoms and urinary flow rate in patients with benign prostatic hyperplasia. Furthermore, the improvement of the complaints after surgery was worse in patients with asymptomatic prostate inflammation. Further well designed prospective-randomised studies are needed to support our findings.

17.
Urol J ; 15(5): 280-284, 2018 09 26.
Article in English | MEDLINE | ID: mdl-29900523

ABSTRACT

PURPOSE: Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are common medical problems, particularlyamong older women. In this study, we aim to explore the relationship between the neurotransmitter nNOS in the vaginal epithelium, and the occurrence of SUI and changes of nNOS levels according to menopausal status.Matherials and Methods: Fourty women were enrolled. The patients were divided into four groups according to menstruaiton status and SUI. The vagina specimens were taken during transobturator tape application. The specimens were examined pathologically in terms of n-NOS expression. nNOS expression was compared between SUI and control groups. The results were evaluated statistically. RESULT: Epithelial total nNOS score in group 1 and group 3 were 2.4 ± 0.5 and 1.4 ± 0.5 respectively (P = .003). Stromal total nNOS score was found 2.2 ± 0.4 in group 1 and 1.3 ± 0.5 in group 3 (P = .001). Epithelial total nNOS score in group 2 and group 4 were 4.4 ± 0.5 and 3.5 ± 0.5 respectively (P = .003). Stromal total nNOS score was found 4.4 ± 0.5 in group 2 and 3.6 ± 0.5 in group 4 ( P = .006). CONCLUSION: Our results show that expression of nNOs in the anterior vaginal epithelium decreased significantly in the SUI group. Altough our findings indicate important results, well designed further studies are needed to comprehend the role of NOS pathways better in SUI pathophysiology.


Subject(s)
Mucous Membrane/innervation , Neurons/metabolism , Nitric Oxide Synthase/metabolism , Urinary Incontinence, Stress/metabolism , Vagina/innervation , Adult , Female , Humans , Immunohistochemistry , Menopause/metabolism , Middle Aged
18.
Aging Male ; 21(3): 206-210, 2018 Sep.
Article in English | MEDLINE | ID: mdl-29338524

ABSTRACT

OBJECTIVE: Visceral adiposity index (VAI) is a novel indicator for the assessment of visceral obesity. In this study, we aimed to evaluate the relationship between VAI and premature ejaculation (PE). MATERIALS AND METHOD: A total of 300 men were included in the study. Hundred and fifty men with PE and 150 men without PE (control). All men were evaluated for PE by premature ejaculation diagnostic tool (PEDT). VAI levels were calculated using body mass index (BMI), high density lipoprotein and triglyceride (TG) levels. RESULTS: Mean age of the study groups was 34.3 ± 5.2 (30-60) years and the mean age of the controls were 35.9 ± 5.3 (30-60) years. The men with PE had lower BMI, TG levels, waist circumference (WC) and higher high-density lipoprotein-cholesterol (HDL-C) levels. Mean VAI level was 4.13 ± 0.7 in study group and 5.72 ± 1.6 in control group, respectively. VAI levels were statistically higher in men without PE (p < .001). DISCUSSION: Our cross-sectional study demonstrated a negative correlation between VAI and PE. VAI is superior index for the evaluation and calculation the relationship between obesity and PE.


Subject(s)
Intra-Abdominal Fat/physiopathology , Obesity, Abdominal/complications , Premature Ejaculation/complications , Adult , Body Mass Index , Case-Control Studies , Cholesterol, HDL/blood , Cross-Sectional Studies , Humans , Male , Middle Aged , Premature Ejaculation/blood , Premature Ejaculation/physiopathology , Prospective Studies , Surveys and Questionnaires , Triglycerides/blood , Waist Circumference
19.
Urol J ; 14(6): 5051-5056, 2017 Nov 04.
Article in English | MEDLINE | ID: mdl-29101760

ABSTRACT

PURPOSE: Sexual functions in the males with obstructive sleep apnea syndrome (OSAS) have been well investigated in the literature; however sexual functions in the premenopausal women with OSAS have been studied to a lesser extent. MATERIALS AND METHODS: The study included 22 premenopausal women diagnosed as OSAS by the polysomnographic (PSG) evaluation. The control group included 13 premenopausal women suspected of sleep-relatedrespiratory disorder, but whose PSG tests were determined to be normal. Both groups were administered Epworth Sleep Scale (ESS), Beck Depression Scale (BDS), and Female Sexual Function Index (FSFI) questionnaire forms. Relations between disease parameters, and the total FSFI score, and scores of the six FSFI parameter were analyzed. RESULTS: The total FSFI score in the cases with OSAS, was determined to be significantly lower than that of the control subjects (P = .031). Scores of the desire, arousal, and orgasm were determined to be significantly lower inthe patient group, compared to control group (P = .034; P = .048; P = .039). The total FSFI scores, and scores of the desire, arousal, lubrication, orgasm, satisfaction and pain subscales in the cases did not correlate significantly with the apnea-hypopnea index (AHI), Non-Rapid Eye Movement 1 (NREM1)%, NREM2%, NREM3%, REM%, the time spent with saturation O2< 90%, minimum oxygen saturation (%), ESS scores, and BDS scores (all P > .05). CONCLUSION: Women with OSAS experience sexual dysfunction when compared with normal population. Clinical evaluation has to include also the evaluation of sexual life in women.


Subject(s)
Sexual Dysfunction, Physiological/etiology , Sexual Dysfunctions, Psychological/etiology , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/psychology , Adult , Arousal , Female , Humans , Middle Aged , Orgasm , Oxygen/blood , Personal Satisfaction , Premenopause , Severity of Illness Index , Sexual Dysfunction, Physiological/physiopathology , Sexual Dysfunctions, Psychological/physiopathology , Sleep Apnea, Obstructive/physiopathology , Surveys and Questionnaires
20.
Arch Ital Urol Androl ; 89(1): 26-30, 2017 Mar 31.
Article in English | MEDLINE | ID: mdl-28403591

ABSTRACT

OBJECTIVE: We evaluated the correlation between benign prostate hyperplasia (BPH) measures and diabetes mellitus in men with benign prostate hyperplasia in a prospective study. MATERIALS AND METHODS: Between 2008-2012, 100 diabetic and 200 non diabetic patients undergoing surgery due to benign prostate hyperplasia were enrolled in the study. The parameters evaluated for each patients included prostate volume, fasting blood glucose, HbA1c, total testosterone, total prostatic specific antigen (T-PSA), triglicerides, total cholesterol and body mass index (BMI). A questionnaire including international prostate symptom score (IPSS) was sdministered and uroflow test measuring the peak urinary flow rate was performed to appreciate the complaints of the patients objectively. RESULTS: Diabetic patients are more likely to have larger prostate volume. The symptom score evaluated by IPSS and post micturition residual volume were also significantly higher in diabetic groups. The other statistically significant different parameter between two groups was total testosterone that diabetic patients tend to have lower levels. Diabetic counterparts were established to have higher BMI. No statistically significant differentiation was observed about trigliceryde and total cholesterol levels and uroflow rates. CONCLUSIONS: Our study suggests a positive correlation between high prostate volume and diagnosis of diabetes mellitus in patients with benign prostatic hyperplasia. We also observed a positive correlation between symptom scores and post micturion residual volumes and diagnosis of diabetes mellitus suggesting that the presence of diabetes is related to both static and dynamic components of benign prostate hyperplasia. Additionally testosterone levels were lower in diabetic patients. Further studies need to confirm these relationship in a larger population.


Subject(s)
Diabetes Mellitus/epidemiology , Prostate-Specific Antigen/blood , Prostatic Hyperplasia/pathology , Triglycerides/blood , Aged , Blood Glucose/metabolism , Body Mass Index , Cholesterol/blood , Humans , Male , Middle Aged , Prospective Studies , Surveys and Questionnaires , Testosterone/blood , Urination/physiology
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