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1.
Med Biol Eng Comput ; 62(7): 2165-2176, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38483711

ABSTRACT

The early diagnosis of brain tumors is critical in the area of healthcare, owing to the potentially life-threatening repercussions unstable growths within the brain can pose to individuals. The accurate and early diagnosis of brain tumors enables prompt medical intervention. In this context, we have established a new model called MTAP to enable a highly accurate diagnosis of brain tumors. The MTAP model addresses dataset class imbalance by utilizing the ADASYN method, employs a network pruning technique to reduce unnecessary weights and nodes in the neural network, and incorporates Avg-TopK pooling method for enhanced feature extraction. The primary goal of our research is to enhance the accuracy of brain tumor type detection, a critical aspect of medical imaging and diagnostics. The MTAP model introduces a novel classification strategy for brain tumors, leveraging the strength of deep learning methods and novel model refinement techniques. Following comprehensive experimental studies and meticulous design, the MTAP model has achieved a state-of-the-art accuracy of 99.69%. Our findings indicate that the use of deep learning and innovative model refinement techniques shows promise in facilitating the early detection of brain tumors. Analysis of the model's heat map revealed a notable focus on regions encompassing the parietal and temporal lobes.


Subject(s)
Brain Neoplasms , Humans , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/pathology , Brain Neoplasms/diagnosis , Neural Networks, Computer , Deep Learning , Algorithms , Diagnosis, Computer-Assisted/methods , Magnetic Resonance Imaging/methods
2.
Burns ; 36(4): 539-44, 2010 Jun.
Article in English | MEDLINE | ID: mdl-19766400

ABSTRACT

Studies aimed at recovering the zone of stasis are one of the major issues of experimental burn studies. Hypoxia and oedema at that zone may cause irreversible changes. Due to anti-oedematous and antihypoxic effects of hyperbaric oxygen treatment (HBOT), it may be beneficial in recovering the zone of stasis. We performed an experimental study using 20 Sprague-Dawley rats, each weighing 350-450 g. The rats were first divided into two groups as 24h and 5 days. Subsequently, control and treatment groups (five rats in each group) were formed. For burn wounds, we used the burn comb model, which was described by Regas and Ehrlich. In the treatment group, 2.5 ATA HBOT was applied for 90 min twice daily. A 0.8-cm punch biopsy was performed and samples for histological examination were taken from the centre of burn area. The rats were sacrificed by administering '3 mci technetium-99m methoxy butyl nitrite' ((99)Tc(m) MIBI) through the femoral vein. Biopsy materials were evaluated by histological and immunohistochemical methods. Dorsal skin fragment, excised to 1cm margin, was imaged by scintigraphic measurements with a gamma camera. Wet and dry weight measurements of excised skin fragments were taken. As a result, HBOT showed a positive effect at the cellular level in the first 24h. It increased recovery potential by augmenting neovascularisation and decreasing oedema in the 5-day group.


Subject(s)
Burns/therapy , Hyperbaric Oxygenation , Skin/blood supply , Animals , Biopsy , Burns/pathology , Disease Models, Animal , Edema/pathology , Edema/prevention & control , Hypoxia/pathology , Hypoxia/prevention & control , Immunohistochemistry , Necrosis/prevention & control , Rats , Rats, Sprague-Dawley , Skin/injuries , Wound Healing/physiology
3.
Am J Pathol ; 161(2): 449-57, 2002 Aug.
Article in English | MEDLINE | ID: mdl-12163370

ABSTRACT

Dilated cardiomyopathy is a syndrome characterized by cardiac enlargement and impaired systolic function of the heart. Tumor necrosis factor (TNF)-alpha, a pleiotropic cytokine, seems to play a central role in the progression of dilated cardiomyopathy. Recent data suggest that ongoing inflammation in the myocardium may, in many cases, contribute to the development of disease. Chronic generation of autoantibodies to myocardial antigens or, in some cases, viral infection are pathobiologically involved. Although both antibodies and some viruses activate the complement system, the role of innate immunity in dilated cardiomyopathy has as yet not been investigated systematically. In this study we demonstrate by analysis of myocardial biopsies from 28 patients that C5b-9, the terminal membrane attack complex of complement, accumulates in human myocardium in dilated cardiomyopathy. C5b-9 significantly correlates with immunoglobulin deposition and myocardial expression of TNF-alpha. In vitro, C5b-9 attack on cardiac myocytes induces nuclear factor (NF)-kappaB activation as well as transcription, synthesis, and secretion of TNF-alpha. We conclude that chronic immunoglobulin-mediated complement activation in the myocardium may contribute in part to the progression of dilated cardiomyopathy via C5b-9-induced TNF-alpha expression in cardiac myocytes.


Subject(s)
Cardiomyopathy, Dilated/immunology , Complement Activation/immunology , Complement Membrane Attack Complex/immunology , Tumor Necrosis Factor-alpha/immunology , Animals , Cardiomyopathy, Dilated/etiology , Cardiomyopathy, Dilated/pathology , Humans , Male , Myocardium/immunology , Myocardium/pathology , Rats , Rats, Wistar , Tumor Necrosis Factor-alpha/biosynthesis
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