ABSTRACT
A case of a 43-year-old white woman who was admitted to our clinic with the complaints of chronic sinusitis and wound infection after Caldwell-Luc operation performed for chronic sinusitis is presented. Necrotic lesion then extended to the nasal cavity and skin of the face. The biopsy revealed natural killer/T-cell lymphoma. The patient was treated with chemotherapy; however, the patient died owing to sepsis. Sinonasal lymphoma is a rare disease. It is managed with chemotherapy and radiotherapy. The prognosis is poor. A high index of clinical suspicion is required for early diagnosis.
Subject(s)
Lymphoma, Extranodal NK-T-Cell/pathology , Nose Neoplasms/pathology , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Diagnosis, Differential , Fatal Outcome , Female , Humans , Lymphoma, Extranodal NK-T-Cell/drug therapy , Maxillary Sinusitis/diagnosis , Maxillary Sinusitis/surgery , Necrosis , Nose Neoplasms/drug therapy , Wound Infection/diagnosisSubject(s)
Laryngeal Neoplasms/pathology , Plasmacytoma/pathology , Vocal Cords/pathology , Adult , Biopsy, Needle , Cough/diagnosis , Cough/etiology , Female , Follow-Up Studies , Hoarseness/diagnosis , Hoarseness/etiology , Humans , Immunohistochemistry , Laryngeal Neoplasms/surgery , Laryngoscopy/methods , Microsurgery/methods , Neoplasm Staging/methods , Plasmacytoma/surgery , Risk Assessment , Treatment OutcomeSubject(s)
Neurilemmoma/surgery , Nose Neoplasms/surgery , Adult , Aged , Diagnosis, Differential , Humans , Immunohistochemistry , Male , Nasal Obstruction/etiology , Neurilemmoma/complications , Neurilemmoma/diagnostic imaging , Neurilemmoma/metabolism , Nose Neoplasms/complications , Nose Neoplasms/diagnostic imaging , Nose Neoplasms/metabolism , Tomography, X-Ray ComputedABSTRACT
Mucosal malignant melanomas are rare lesions, and they have different characteristics from their cutaneous counterparts. Since extended excisions of mucosal malignant melanomas located in the oropharyngeal region cause significant morbidity, limited surgical excision comes into consideration. Three cases of extensive oropharyngeal malignant melanomas were resected with 0.5-1.5-cm healthy tissue margins. The cases were followed for local recurrences. Case 1 applied radiotherapy and chemotherapy in addition to immunotherapy, and the patient is still alive without any local recurrences 18 months after surgery. The patient in case 2 underwent radiotherapy and immunotherapy and died 6 months after surgery. The patient in case 3 received chemotherapy in addition to immunotherapy and died 12 months after surgery as a result of distant metastasis. All cases were without any local recurrences. Surgical excision with limited tumor-free tissue margins may be the surgery of choice to prevent morbidity associated with wide resection of oropharyngeal malignant melanomas if other authors also reconfirm these results with many more cases in the future.
