Subject(s)
Rickets/etiology , Calcifediol/blood , Female , Humans , Infant , Infant, Newborn , Mothers , Nigeria , Rickets/bloodSubject(s)
Immunoglobulins, Intravenous/therapeutic use , Prednisone/therapeutic use , Purpura, Thrombocytopenic/drug therapy , Purpura, Thrombocytopenic/therapy , Child , Combined Modality Therapy , Female , Humans , Immunoglobulins, Intravenous/adverse effects , Immunoglobulins, Intravenous/economics , Male , Methylprednisolone/adverse effects , Methylprednisolone/economics , Methylprednisolone/therapeutic use , Prednisone/adverse effects , Prednisone/economics , Purpura, Thrombocytopenic/bloodSubject(s)
Acrodynia/complications , Hypertension/drug therapy , Nifedipine/therapeutic use , Adolescent , Child , Female , Humans , MaleSubject(s)
Purpura, Thrombotic Thrombocytopenic/therapy , Blood Transfusion , Child, Preschool , Chronic Disease , Female , Humans , PlasmaSubject(s)
Osteopetrosis/diagnosis , Osteosclerosis/diagnosis , Diagnosis, Differential , Humans , Infant, NewbornSubject(s)
Anemia, Sickle Cell/blood , Glycated Hemoglobin/analysis , Greece , Hemolysis , Humans , JamaicaSubject(s)
Hyperparathyroidism/complications , Pregnancy Complications , Rickets/etiology , Female , Humans , Infant , Infant, Newborn , Male , PregnancyABSTRACT
This study was aimed at detecting the early appearance of myelofibrosis by bone marrow biopsy examination in children with vitamin D-deficiency rickets. Twelve children, aged 4 to 18 months, were evaluated. Only a minimal increase of the reticulin was shown in rachitic children without anemia in whom no other laboratory evidence of myelofibrosis was present. Early signs of myelofibrosis with increase of reticulin were present in rachitic infants with anemia. In patients of the same age with iron deficiency anemia, the bone marrow reticulin findings were normal. Bone marrow biopsy after successful treatment of rickets could be repeated in one patient with myelofibrosis; results indicated that the myelofibrosis with anemia associated with vitamin D-deficiency rickets is reversible by vitamin D treatment.
Subject(s)
Hypophosphatemia, Familial/complications , Primary Myelofibrosis/diagnosis , Anemia, Hypochromic/blood , Biopsy , Bone Marrow/pathology , Female , Humans , Hypophosphatemia, Familial/blood , Infant , Male , Metaplasia/pathology , Primary Myelofibrosis/blood , Primary Myelofibrosis/pathologyABSTRACT
Administration of propranolol to 13 children with portal hypertension reduced splenic pulp pressure by greater than 50 mm H2O (P less than 0.01) in approximately 2 weeks, when the pulse rate became three fourths the initial rate. The influence was found to be greater in compensated than in decompensated portal hypertension. This observation might be interpreted to mean that the effect of propranolol in the reduction of portal venous pressure results not only from decreased intestinal blood flow secondary to decreased cardiac output but also to the stimulation of sympathetic nervous system alpha-adrenoreceptors of the portal tract. Although arterial blood pressure changes were not significant, peripheral venous pressure was reduced significantly (P less than 0.01). We conclude that propranolol has considerable usefulness in treating portal hypertension in children.