ABSTRACT
Isotretinoin, a medication for acne, has been reported to cause a variety of side effects on the musculoskeletal system. We present a case of sacroiliitis (a relatively uncommon feature) and sensorimotor demyelinating polyneuropathy, which has been reported previously in only a few cases during isotretinoin therapy. Clinical symptoms were improved after the withdrawal of isotretinoin and the follow-up electrophysiological study performed 2 years after the initial diagnosis of polyneuropathy showed mild improvement. Dermatologists are advised to be alert to symptoms of polyneuropathy and sacroiliitis during treatment with isotretinoin.
Subject(s)
Arthritis/chemically induced , Demyelinating Diseases/chemically induced , Dermatologic Agents/adverse effects , Isotretinoin/adverse effects , Polyneuropathies/chemically induced , Sacroiliac Joint/drug effects , Acne Vulgaris/drug therapy , Adult , Arthritis/metabolism , Demyelinating Diseases/diagnostic imaging , Dermatologic Agents/administration & dosage , Dose-Response Relationship, Drug , Humans , Isotretinoin/administration & dosage , Male , Polyneuropathies/diagnostic imaging , Radiography , Sacroiliac Joint/diagnostic imaging , Sacroiliac Joint/metabolism , Treatment Outcome , Withholding TreatmentABSTRACT
The temporal lobe agenesis syndrome is a rare congenital abnormality. This syndrome frequently has been described in association with arachnoid cysts or abnormal collections of cerebrospinal fluid. Arachnoid cysts develop most frequently in the middle cranial fossa and almost all these cysts are unilateral. Bilateral middle cranial fossa arachnoid cysts are extremely rare and only 9 cases have been reported in the literature. We present an adult case with bilateral arachnoid cysts and temporal lobe agenesis whose mental examination and neurologic assessment is normal. The cysts are demonstrated by CT and metrizamid CT cysternography.
