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2.
Cureus ; 15(12): e50795, 2023 Dec.
Article in English | MEDLINE | ID: mdl-38116022

ABSTRACT

Aim The aim of this study is to define genomic variations between fibrolamellar hepatocellular carcinoma (FL-HCC) and conventional hepatocellular carcinoma (HCC) Methods This study used the American Association for Cancer Research (AACR) Project GENIE data as a foundational element. Specifically, information about both fibrolamellar and conventional hepatocellular carcinoma was retrieved from this database. Results A total of 719 patients diagnosed with HCC and 52 individuals presenting with FL-HCC underwent thorough analysis. Notably, distinct variances in gene alterations were observed between the two cohorts. Predominantly, the HCC group exhibited frequent occurrences of mutations within the TP53 and CTNNB1 genes. Conversely, DNAJB1 fusion was uniquely identified in FL-HCC cases. Conclusion This study significantly broadens our understanding of the genetic makeup associated with FL-HCC and HCC. It is particularly notable because it reveals clear disparities in gene modifications between FL-HCC and HCC. Further investigation is essential to unravel the functional consequences of these genetic variances. This exploration will aid in the development of targeted therapeutic approaches to enhance the prognosis of patients diagnosed with diverse subtypes of HCC.

3.
Dalton Trans ; 52(38): 13587-13593, 2023 Oct 03.
Article in English | MEDLINE | ID: mdl-37697959

ABSTRACT

Pyrene-substituted amphiphilic ATRP polymers (P1) were used to stabilize the pyrene-substituted gold(I) NHC complex (Au-1) within the hydrophobic compartment of micellar structures in a methanol/water mixture through non-covalent π-π stacking interactions. The stacking interactions between pyrene groups of the polymer and the catalyst were investigated by means of fluorescence spectroscopy by comparing excimer and monomer emission signals of the pyrene moiety. The supported catalyst (Au-1@P1) formed spherical micellar structures in a water/methanol mixture with an average size of 55.6 (±13.1) nm as confirmed from TEM analysis. The performance of the catalytic system was tested on alkyne hydration reactions of alkynes. When compared to the unsupported analog, the supported catalyst showed an improved performance as a result of stabilization through π-stacking interactions within the hydrophobic compartment in the micellar structure.

4.
Future Oncol ; 14(15): 1461-1467, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29741392

ABSTRACT

AIM: There are inconsistent results about the effects of vitamin D level on breast cancer prognosis. We aimed to investigate the effect of vitamin D levels on the prognosis of resectable breast cancer in a patient group with highly different clothing styles. PATIENTS & METHODS: A total of 186 breast cancer patients were enrolled in the study. RESULTS: Vitamin D level was sufficient, insufficient and deficient in 17.2, 52.2 and 30.6% of patients, respectively. There was a significant relationship between clothing style and serum 25 (OH) D levels. We could not establish any relation between vitamin D level and tumor characteristics or survival. CONCLUSION: Vitamin D supplementation can be more important than diagnostic serum vitamin D level on prognosis of breast cancer.


Subject(s)
Breast Neoplasms/blood , Neoplasm Recurrence, Local/epidemiology , Vitamin D/blood , Adult , Aged , Aged, 80 and over , Antineoplastic Agents/therapeutic use , Breast/pathology , Breast/surgery , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Breast Neoplasms/therapy , Chemotherapy, Adjuvant , Disease-Free Survival , Female , Follow-Up Studies , Humans , Mastectomy , Middle Aged , Neoplasm Recurrence, Local/blood , Neoplasm Recurrence, Local/pathology , Prognosis , Reproducibility of Results , Treatment Outcome , Turkey , Vitamin D/therapeutic use , Young Adult
5.
Amyloid ; 24(3): 176-182, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28686525

ABSTRACT

In AA amyloidosis, while kidney biopsy is widely considered for diagnosis by clinicians, there is no evidence that the detailed investigation of renal histopathology can be utilized for the prognosis and clinical outcomes. In this study, we aimed to obtain whether histopathologic findings in kidney biopsy of AA amyloidosis might have prognostic and clinical value. This is a retrospective cohort study that included 38 patients who were diagnosed with AA amyloidosis by kidney biopsy between 2005 and 2013.The kidney biopsy specimens of patients were evaluated and graded for several characteristics of histopathological lesions and their relationship with renal outcomes. Segmental amyloid deposition in the kidney biopsy was seen in 29%, global amyloid deposition in 71, diffuse involvement of glomeruli in 84.2%, focal involvement in 7%, glomerular enlargement in 53%, tubular atrophy in 75% and interstitial fibrosis in 78% of patients. Histopathologically, glomerular enlargement, interstitial fibrosis, tubular atrophy, interstitial inflammation and global amyloid deposition were significantly associated with lower estimated glomerular filtration rate (eGFR) (p = .02, p < .001, p = .001, p = .009, p = .002, respectively) in univariate analysis. In multivariate analysis, tubular atrophy was the only predictor of eGFR (p = .019 B = -20.573). In the follow-up at an average of 27 months, 18 patients developed end-stage renal disease (ESRD). Among them, global amyloid deposition was the only risk factor for the development of ESRD (p = .01, OR = 18.750, %95 CI= 2.021-173.942). This is the first study showing that the histopathological findings in kidney biopsy of AA amyloidosis might have a prognostic and clinical value for renal outcomes.


Subject(s)
Amyloid/metabolism , Amyloidosis , Kidney Glomerulus/metabolism , Kidney Glomerulus/pathology , Adult , Aged , Amyloidosis/diagnosis , Amyloidosis/metabolism , Amyloidosis/pathology , Biopsy , Female , Glomerular Filtration Rate , Humans , Male , Middle Aged , Prognosis , Retrospective Studies
6.
Turk J Haematol ; 34(1): 16-26, 2017 Mar 01.
Article in English | MEDLINE | ID: mdl-27094579

ABSTRACT

OBJECTIVE: Tyrosine kinase inhibitors (TKIs) have changed the indications for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in chronic myeloid leukemia (CML). Therefore, we aimed to evaluate the effect of TKIs on allo-HSCT in CML. MATERIALS AND METHODS: In this quasi-experimental study, we compared patient, disease, and transplantation characteristics as well as allo-HSCT outcomes between the pre-TKI era (before 2002) and the post-TKI era (2002 and later) in patients with CML. A total of 193 allo-HSCTs were performed between 1989 and 2012. RESULTS: Patients in the post-TKI era had more advanced disease (>chronic phase 1) at the time of transplant and more frequently received reduced-intensity conditioning compared to patients in the pre-TKI era. Relapse/progression occurred more frequently in the year ≥2002 group than in the year <2002 group (48% vs. 32% at 5 years, p=0.01); however, overall survival (OS) was similar in these two groups (5-year survival was 50.8% vs. 59.5%, respectively; p=0.3). TKIs (with donor lymphocyte infusions or alone) for treatment of relapse after allo-HSCT were available in the post-TKI era and were associated with improved OS. While the rates of hematologic remission at 3 months after allo-HSCT were similar between TKI eras, patients having remission had better disease-free survival (DFS) [relative risk (RR): 0.15, confidence interval (CI) 95%: 0.09-0.24, p<0.001] and OS (RR: 0.14, CI 95%: 0.09-0.23, p<0.001). Male allo-HSCT recipients had worse DFS (RR: 1.7, CI 95%: 1.2-2.5, p=0.007) and OS (RR: 1.7, CI 95%: 1.1-2.6, p=0.02) than females. CONCLUSION: TKIs are an effective option for the treatment of relapse after allo-HSCT in CML. Hematologic remission after allo-HSCT is also an important factor for survival in CML patients.


Subject(s)
Hematopoietic Stem Cell Transplantation , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Protein Kinase Inhibitors/therapeutic use , Adolescent , Adult , Disease-Free Survival , Female , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy , Male , Middle Aged , Neoplasm Staging , Non-Randomized Controlled Trials as Topic , Recurrence , Risk , Sex Factors , Transplantation, Homologous , Treatment Outcome , Young Adult
7.
Turk J Haematol ; 33(1): 41-7, 2016 Mar 05.
Article in English | MEDLINE | ID: mdl-26376622

ABSTRACT

OBJECTIVE: The increased risk of infection for patients caused by construction and renovation near hematology inpatient clinics is a major concern. The use of high-efficiency particulate absorption (HEPA) filters can reduce the risk of infection. However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation. This quasi-experimental study was designed to measure the efficacy of HEPA filters in preventing infections during construction. MATERIALS AND METHODS: Portable HEPA filters were placed in the rooms of patients undergoing treatment for hematological malignancies because of large-scale construction taking place near the hematology clinic. The rates of infection during the 6 months before and after the installation of the portable HEPA filters were compared. A total of 413 patients were treated during this 1-year period. RESULTS: There were no significant differences in the antifungal prophylaxis and treatment regimens between the groups. The rates of infections, clinically documented infections, and invasive fungal infections decreased in all of the patients following the installation of the HEPA filters. When analyzed separately, the rates of invasive fungal infections were similar before and after the installation of HEPA filters in patients who had no neutropenia or long neutropenia duration. HEPA filters were significantly protective against infection when installed in the rooms of patients with acute lymphocytic leukemia, patients who were undergoing consolidation treatment, and patients who were neutropenic for 1-14 days. CONCLUSION: Despite the advent of construction and the summer season, during which environmental Aspergillus contamination is more prevalent, no patient or patient subgroup experienced an increase in fungal infections following the installation of HEPA filters. The protective effect of HEPA filters against infection was more pronounced in patients with acute lymphocytic leukemia, patients undergoing consolidation therapy, and patients with moderate neutropenia.


Subject(s)
Air Filters , Air Microbiology , Cross Infection/prevention & control , Filtration/instrumentation , Hematologic Neoplasms/complications , Hospital Design and Construction , Infection Control/methods , Opportunistic Infections/prevention & control , Absorption, Physicochemical , Adolescent , Adult , Aged , Aged, 80 and over , Air Filters/economics , Bacterial Infections/epidemiology , Bacterial Infections/etiology , Bacterial Infections/prevention & control , Cross Infection/epidemiology , Cross Infection/etiology , Febrile Neutropenia/complications , Female , Fever of Unknown Origin/epidemiology , Fever of Unknown Origin/etiology , Filtration/economics , Hematologic Neoplasms/therapy , Hospital Charges , Humans , Immunocompromised Host , Infection Control/economics , Infection Control/instrumentation , Invasive Fungal Infections/epidemiology , Invasive Fungal Infections/etiology , Invasive Fungal Infections/prevention & control , Male , Middle Aged , Opportunistic Infections/epidemiology , Opportunistic Infections/etiology , Particulate Matter/adverse effects , Particulate Matter/analysis , Patients' Rooms , Young Adult
8.
J Infect Public Health ; 8(4): 373-6, 2015.
Article in English | MEDLINE | ID: mdl-25899561

ABSTRACT

Q fever has rarely been reported and can be difficult to diagnose, especially in immunocompromised patients. In the present report, we describe an unusual case of Q fever that presented as peritonitis and was treated with long-term combination therapy with doxycycline, ciprofloxacin and rifampicin for five weeks in a patient who had been on peritoneal dialysis for six years due to hypertensive nephropathy.


Subject(s)
Peritonitis/diagnosis , Q Fever/diagnosis , Adult , Anti-Bacterial Agents/therapeutic use , Ciprofloxacin/therapeutic use , Doxycycline/therapeutic use , Drug Therapy, Combination , Humans , Immunocompromised Host/physiology , Male , Peritoneal Dialysis , Peritonitis/drug therapy , Q Fever/drug therapy , Rifampin/therapeutic use
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