Rapid and simple viral protein detection by functionalized 2D MoS2/graphene electrochemiluminescence aptasensor.

In this work we present the development of an electrochemiluminescence aptasensor based on electrografting molybdenum disulphide nanosheets functionalized with diazonium salt (MoS2-N2+) upon screen-printed electrodes of graphene (SPEs GPH) for viral proteins detection. In brief, this aptasensor consists of SPEs GPH electrografted with MoS2-N2+ and modified with a thiolated aptamer, which can specifically recognize the target protein analyte. In this case, we have used SARS-CoV-2 spike protein as model protein. Electrochemiluminescence detection was performed by using the [Ru(bpy)3]2+/TPRA (tripropylamine) system, which allows the specific detection of the SARS-CoV-2 spike protein easily and rapidly with a detection limit of 9.74 fg/mL and a linear range from 32.5 fg/mL to 50.0 pg/mL. Moreover, the applicability of the aptasensor has been confirmed by the detection of the protein directly in human saliva samples. Comparing our device with a traditional saliva antigen test, our aptasensor can detect the spike protein even when the saliva antigen test gives a negative result.

Scope and Limitations of Using Microemulsions for the Covalent Patterning of Graphene.

Patterning of graphene (functionalizing some areas while leaving others intact) is challenging, as all the C atoms in the basal plane are identical, but it is also desirable for a variety of applications, like opening a bandgap in the electronic structure of graphene. Several methods have been reported to pattern graphene, but most of them are very technologically intensive. Recently, we reported the use of microemulsions as templates to pattern graphene at the µm scale. This method is very simple and in principle tunable, as emulsions of different droplet size and composition can be prepared easily. Here, we explore in detail the scope of this methodology by applying it to all the combinations of four different emulsions and three different organic reagents, and characterizing the resulting substrates exhaustively through Raman, SEM and AFM. We find that the method is general, works better when the reactive species are outside the micelles, and requires reactive species that involve short reaction times.

Characterization of emerging 2D materials after chemical functionalization.

The chemical modification of 2D materials has proven a powerful tool to fine tune their properties. With this motivation, the development of new reactions has moved extremely fast. The need for speed, together with the intrinsic heterogeneity of the samples, has sometimes led to permissiveness in the purification and characterization protocols. In this review, we present the main tools available for the chemical characterization of functionalized 2D materials, and the information that can be derived from each of them. We then describe examples of chemical modification of 2D materials other than graphene, focusing on the chemical description of the products. We have intentionally selected examples where an above-average characterization effort has been carried out, yet we find some cases where further information would have been welcome. Our aim is to bring together the toolbox of techniques and practical examples on how to use them, to serve as guidelines for the full characterization of covalently modified 2D materials.

Clicking beyond suspensions: understanding thiol-ene chemistry on solid-supported MoS2.

Molecular functionalization of MoS2 has attracted a lot of attention due to its potential to afford fine-tuned hybrid materials that benefit from the power of synthetic chemistry and molecular design. Here, we report on the on-surface reaction of maleimides on bulk and molecular beam epitaxy grown single-layer MoS2, both in ambient conditions as well as ultrahigh vacuum using scanning probe microscopy.

Automated statistical analysis of raman spectra of nanomaterials.

Both at the academic and the industrial level, material scientists are exploring routes for mass production and functionalization of graphene, carbon nanotubes (CNT), carbon dots, 2D materials, and heterostructures of these. Proper application of the novel materials requires fast and thorough characterization of the samples. Raman spectroscopy stands out as a standard non-invasive technique capable of giving key information on the structure and electronic properties of nanomaterials, including the presence of defects, degree of functionalization, diameter (in the case of CNT), different polytypes, doping, etc. Here, we present a computational tool to automatically analyze the Raman spectral features of nanomaterials, which we illustrate with the example of CNT and graphene. The algorithm manages hundreds of spectra simultaneously and provides statistical information (distribution of Raman shifts, average values of shifts and relative intensities, standard deviations, correlation between different peaks, etc.) of the main spectral features defining the structure and electronic properties of the samples, as well as publication-ready graphical material.

A "signal off-on" fluorescence bioassay based on 2D-MoS2-tetrahedral DNA bioconjugate for rapid virus detection.

In this work we present the preparation of a 2D molybdenum disulphide nanosheets (2D-MoS2) and tetrahedral DNA nanostructures (TDNs) bioconjugate, and its application to the development of a bioassay for rapid and easy virus detection. The bioconjugate has been prepared by using TDNs carrying the capture probe labelled with 6-carboxyfluoresceine (6-FAM). As case of study to assess the utility of the assay developed, we have chosen the SARS-CoV-2 virus. Hence, as probe we have used a DNA sequence complementary to a region of the SARS-CoV-2 ORF1ab gene (TDN-ORF-FAM). This 6-FAM labelled capture probe is located on the top vertex of the tetrahedral DNA nanostructure, the three left vertices of TDNs have a thiol group. These TDNs are bounded to 2D-MoS2 surface through the three thiol groups, allowing the capture probe to be oriented to favour the biorecognition reaction with the analyte. This biorecognition resulting platform has finally been challenged to the detection of the SARS-CoV-2 ORF1ab gene sequence as the target model by measuring fluorescence before and after the hybridization event with a detection limit of 19.7fM. Furthermore, due to high sensitivity of the proposed methodology, it has been applied to directly detect the virus in nasopharyngeal samples of infected patients without the need of any amplification step. The developed bioassay has a wide range of applicability since it can be applied to the detection of any pathogen by changing the probe corresponding to the target sequence. Thus, a novel, hands-on strategy for rapid pathogen detection has proposed and has a high potential application value in the early diagnosis of infections causes by virus or bacteria.

La Cruz Roja española en la profesionalización enfermera entre 1912 y 1939 / Spanish Red Cross In Nursing Professionalization Between 1912 And 1939. Bibliographic Review

Introducción: La fundación de la Cruz Roja Española se puede remontar a la tercera Guerra Carlista, los fines, principios y el servicio de esta institución repercutieron en el desarrollo de la profesión de enfermería en la época. Objetivo: determinar la implicación de la Cruz Roja Española en la profesionalización enfermera entre 1912 y 1939. Material y método: se realizó una búsqueda bibliográfica en los principales portales de búsqueda, así como en bibliotecas de especialización en historia de la enfermería. Resultados: la Cruz Roja Española participó en el desarrollo asistencial y formativo de la enfermería, fundando y regentando hospitales propios y hospitales de campaña para atender a los heridos surgidos de diferentes conflictos bélicos, como las propias Guerras Carlistas, la Guerra del Rif o la Guerra Civil Española. En la formación fundaron diversos Hospitales-Escuelas que impartían una formación teórico-práctica, supervisada por monjas religiosas. Conclusión: la participación de la Cruz Roja en la profesionalización enfermera radica en la colaboración, atención y asistencia de los heridos en numerosos conflictos bélicos a nivel nacional, como fueron las Guerras Carlistas, la Guerra del Rif y la Guerra Civil Española. La Cruz Roja también participó en el avance y mejora de la formación reglada hasta la época, contando con figuras como la de Dama Enfermera, Enfermeras profesionales y enfermeras especialistas. (AU)

Background: The foundation of the Spanish Red Cross can be traced back to the third Carlist War, the purposes, principles, and service of this institution had an impact on the development of the nursing profession at the time. Objective: to determine the involvement of the Spanish Red Cross in nursing professionalization between 1912 and 1939. Methods: A bibliographic search was carried out in the main search portals, as well as in specialized libraries in nursing history. Results: The Spanish Red Cross participated in the development of nursing care and training, founding and running its own hospitals and field hospitals to care for the wounded from various wars, such as the Carlist Wars themselves, the Rif War or the Spanish Civil War. In the training they founded various Hospital-Schools that provided theoretical practical training, supervised by religious nuns. Conclusion: The participation of the Red Cross in the professionalization of nursing lies in the collaboration, care, and assistance of the wounded in numerous armed conflicts at the national level, such as the Carlist Wars, the Rif War and the Spanish Civil War. The Red Cross also participated in the advancement and improvement of regulated training up to that time, with figures such as the Lady Nurse, professional nurses, and specialist nurses. (AU)

Multiplex Portable Biosensor for Bacteria Detection.

An advanced, cost-effective, and portable DNA biosensor capable of detecting multiple bacteria simultaneously has been developed. The biosensor comprises a fast and inexpensive potentiostat that controls the applied potential to a screen-printed electrochemical array platform functionalized with MoS2 flakes and bacterial DNA probes. The current response obtained by à la carte thionine functionalized carbon nanodots (Ty-CDs) is monitored as an electrochemical indicator of the hybridization event. The design of the potentiostat prioritizes achieving an optimal signal-to-noise ratio and incorporates a user-friendly interface compatible with various devices, including computers, mobile phones, and tablets. The device is compact, lightweight, and manufactured at a low cost. The key components of the potentiostat include a data acquisition board capable of analyzing multiple samples simultaneously and a controller board. The results of this study confirm the ability of the multiplex portable biosensor to successfully detect specific bacterial DNA sequences, demonstrating its reliability and superior performance compared with a traditional, more complex, and laboratory-oriented potentiostat.

Interlocking Matrix and Filler for Enhanced Individualization and Reinforcement in Polymer-Single-Walled Carbon Nanotube Composites.

Poor individualization and interfacial adhesion prevent single-walled carbon nanotube (SWNT)-polymer composites from reaching outstanding mechanical properties. With much larger diameters, but common structural features (high aspect ratio and absence of functional groups for covalent or supramolecular attachment with the polymer), carbon fibers face similar problems, which are addressed by covering the fibers with a thin layer of polymer. This sizing strategy has allowed carbon fibers to become the filler of choice for the highest performing materials. Inspired by this, here we investigate the use of the mechanical bond to wrap SWNTs with a layer of polymeric material to produce SWNTs mechanically interlocked with a layer of polymer. We first validate the formation of mechanically interlocked nanotubes (MINTs) using mixtures of SWNTs of relatively large average diameter (1.6 ± 0.4 nm), which are commercially available at reasonable prices and therefore could be technologically relevant as polymer fillers. We then design and synthesize by ring-opening metathesis polymerization (ROMP) a polymer decorated with multiple U-shaped molecules, which are later ring-closed around the SWNTs using metathesis. The obtained hybrids contain a high degree of individualized SWNTs and exhibit significantly increased mechanical properties when compared to the matrix polymer. We envision that this strategy could be employed to produce SWNTs interlocked with polymer layers with various designs for polymer reinforcement.

Assessing the Adjuvant Effect of Layered Double Hydroxides (LDH) on BALB/c Mice.

The discovery and validation of new adjuvants are critical areas for vaccinology. Mineral materials (e.g., alum microparticles) have been used for a long time as adjuvants in human vaccine formulations. Nonetheless, the use of nanosized materials is a promising approach to diversify the properties of adjuvants. Nanoclays are potential adjuvants proposed by some research groups. However, their adjuvant mechanisms and safety have not been fully elucidated. Herein, we aimed at expanding the knowledge on the potential adjuvanticity of layered double hydroxide (LDH) nanoparticles by reporting a detailed method for the synthesis and characterization of LDHs and the adsorption of a model antigen (bovine serum albumin, BSA). LDHs varying in diameter (from 56 to 88 nm) were obtained, and an in vitro evaluation revealed that the LDHs are not inherently toxic. BSA was passively adsorbed onto the LDHs, and the immunogenicity in mice of the conjugates obtained was compared to that of free BSA and BSA co-administered with alum (Alum-BSA). The LDH-BSA conjugates induced a higher humoral response that lasted for a longer period compared with that of free BSA and Alum-BSA, confirming that LDH exerts adjuvant effects. The 56 nm LDH particles were deemed as the more efficient carrier since they induced a higher and more balanced Th1/Th2 response than the 88 nm particles. This study is a contribution toward expanding the characterization and use of nanoclays in vaccinology and justifies further studies with pathogen-specific antigens.

Mechanical Interlocking to Unlock the Reinforcing Potential of Carbon Nanotubes.

Single-walled carbon nanotubes (SWNTs) present extraordinary mechanical properties, with Youngs' modulus>1 TPa and tensile strength>50 GPa; this makes them ideal candidates as fillers for the reinforcement of polymers. However, the performance of SWNTs in this field has fallen behind expectations. This is due to a combination of imperfect individualization of the SWNTs and poor load transfer from the polymer to the SWNTs. Here, we study the reinforcement of polymers of different chemical nature using mechanically interlocked derivatives of single-walled carbon nanotubes (MINTs). We compare the mechanical properties of fibers made of poly (methyl methacrylate) (PMMA) and polysulfone (PSU) and their composites made with pristine SWNTs, MINTs, and the corresponding supramolecular models. With very low loading of MINTs (0.01 % w/w), improvements of more than 100 % on Youngs Modulus and the tensile strength are observed for both the nonpolar aliphatic PMMA and the very polar aromatic PSU polymers, while pristine carbon nanotubes and the supramolecular nanofillers showed smaller reinforcement. These data, together with our previous report on the reinforcement of polystyrene (nonpolar and aromatic), indicate that derivatization of SWNTs as MINTs is a valid general strategy to optimize the interaction between SWNT fillers and the polymer matrix.

Solar Energy Storage Using a Cu2 O-TiO2 Photocathode in a Lithium Battery.

A Cu2 O-TiO2 photoelectrode is pr+oposed for simultaneous solar light energy harvesting and storing of electrochemical energy in an adapted lithium coin cell. The p-type Cu2 O semiconductor layer is the light harvester component of the photoelectrode and the TiO2 film performs as the capacitive layer. The rationale of the energy scheme shows that the photocharges generated in the Cu2 O semiconductor induce lithiation/delithiation processes in the TiO2 film as a function of the applied bias voltage and light power. A photorechargeable lithium button cell drilled on one side recharges with visible white light in ≈9 h in open circuit. It provides an energy density of ≈150 mAh g-1 at 0.1 C discharge current in dark, and the overall efficiency is 0.29%. This work draws a new approach for the photoelectrode role to advance in monolithic rechargeable batteries.

MoS2-Carbon Nanodots as a New Electrochemiluminescence Platform for Breast Cancer Biomarker Detection.

In this work, we present the combination of two different types of nanomaterials, 2D molybdenum disulfide nanosheets (MoS2-NS) and zero-dimensional carbon nanodots (CDs), for the development of a new electrochemiluminescence (ECL) platform for the early detection and quantification of the biomarker human epidermal growth factor receptor 2 (HER2), whose overexpression is associated with breast cancer. MoS2-NS are used as an immobilization platform for the thiolated aptamer, which can recognize the HER2 epitope peptide with high affinity, and CDs act as coreactants of the anodic oxidation of the luminophore [Ru(bpy)3]2+. The HER2 biomarker is detected by changes in the ECL signal of the [Ru(bpy)3]2+/CD system, with a low detection limit of 1.84 fg/mL and a wide linear range. The proposed method has been successfully applied to detect the HER2 biomarker in human serum samples.

Microwave-Driven Exfoliation of Bulk 2H-MoS2 after Acetonitrile Prewetting Produces Large-Area Ultrathin Flakes with Exceptionally High Yield.

2D materials display exciting properties in numerous fields, but the development of applications is hindered by the low yields, high processing times, and impaired quality of current exfoliation methods. In this work we have used the excellent MW absorption properties of MoS2 to induce a fast heating that produces the near-instantaneous evaporation of an adsorbed, low boiling point solvent. The sudden evaporation creates an internal pressure that separates the MoS2 layers with high efficiency, and these are kept separated by the action of the dispersion solvent. Our fast method (90 s) gives high yields (47% at 0.2 mg/mL, 35% at 1 mg/mL) of highly exfoliated material (90% under 4 layers), large area (up to several µm2), and excellent quality (no significant MoO3 detected).

Direct Magnetic Evidence, Functionalization, and Low-Temperature Magneto-Electron Transport in Liquid-Phase Exfoliated FePS3.

Magnetism and the existence of magnetic order in a material is determined by its dimensionality. In this regard, the recent emergence of magnetic layered van der Waals (vdW) materials provides a wide playground to explore the exotic magnetism arising in the two-dimensional (2D) limit. The magnetism of 2D flakes, especially antiferromagnetic ones, however, cannot be easily probed by conventional magnetometry techniques, being often replaced by indirect methods like Raman spectroscopy. Here, we make use of an alternative approach to provide direct magnetic evidence of few-layer vdW materials, including antiferromagnets. We take advantage of a surfactant-free, liquid-phase exfoliation (LPE) method to obtain thousands of few-layer FePS3 flakes that can be quenched in a solvent and measured in a conventional SQUID magnetometer. We show a direct magnetic evidence of the antiferromagnetic transition in FePS3 few-layer flakes, concomitant with a clear reduction of the Néel temperature with the flake thickness, in contrast with previous Raman reports. The quality of the LPE FePS3 flakes allows the study of electron transport down to cryogenic temperatures. The significant through-flake conductance is sensitive to the antiferromagnetic order transition. Besides, an additional rich spectra of electron transport excitations, including secondary magnetic transitions and potentially magnon-phonon hybrid states, appear at low temperatures. Finally, we show that the LPE is additionally a good starting point for the mass covalent functionalization of 2D magnetic materials with functional molecules. This technique is extensible to any vdW magnetic family.

Design and Manipulation of a Minimalistic Hydrocarbon Nanocar on Au(111).

Nanocars are carbon-based single-molecules with a precise design that facilitates their atomic-scale control on a surface. The rational design of these molecules is important in atomic and molecular-scale manipulation to advance the development of molecular machines, as well as for a better understanding of self-assembly, diffusion and desorption processes. Here, we introduce the molecular design and construction of a collection of minimalistic nanocars. They feature an anthracene chassis and four benzene derivatives as wheels. After sublimation and adsorption on an Au(111) surface, we show controlled and fast manipulation of the nanocars along the surface using the tip of a scanning tunneling microscope (STM). The mechanism behind the successful displacement is the induced dipole created over the nanocar by the STM tip. We utilized carbon monoxide functionalized tips both to avoid decomposition and accidentally picking the nanocars up during the manipulation. This strategy allowed thousands of maneuvers to successfully win the Nanocar Race II championship.

La profesión enfermera en el ejército y en la aeronáutica española (1855-1931) / The Nursing Profession In The Spanish Army And Aeronautics. Between 1855 And 1931. A Bibliographic Review

Introducción: La asistencia a los heridos en el campo de combate crea la necesidad de integrar de una manera razonada la medicina, la táctica militar y la enfermería, consistiendo esta última en la administración de cuidados prehospitalarios, procedimientos quirúrgicos y estabilización de los heridos. Objetivo: determinar las principales funciones de la profesión enfermera en el Ejército y la Aeronáutica Españolas entre 1855 y 1931. Material y método: se ha realizado una revisión bibliográfica de las principales bases de datos y motores de búsqueda científicos, así como de bibliotecas especializadas en historia de la enfermería. Los criterios de inclusión han sido: documentos que analizasen las funciones de los practicantes, enfermeros y enfermeras militares; así como su rango y escalafón. Resultados: a partir del año 1855 con la organización de la Escala Facultativa, la figura de practicante militar deja de ser una figura destinada a ser un futuro médico para incorporar funciones y responsabilidades propias. La Guerra de Marruecos implicó que la logística militar se especializase, creando aeronaves para tácticas militares con la apertura del aeródromo de Cuatro Vientos (Madrid) en 1911 y realizando la primera misión de aeroevacuación española en la misma Guerra del Rif en el año 1922. No sería hasta el año 1988 cuando la mujer se pudo incorporar al Ejército como militar profesional. Conclusión: Los aportes del ejército y aeronáutica españolas a la profesión de enfermería radican principalmente en tres grandes campos, el ámbito extrahospitalario, el ámbito de la cirugía general y vascular y el campo de la traumatología. (AU)

Background: Assistance to the wounded in the combat field creates the need to integrate medicine, military tactics and nursing in a reasoned manner, the latter consisting of the administration of prehospital care, surgical procedures and stabilization of the wounded. Objective: to determine the main functions of the nursing profession in the Spanish Army and Aeronautics between 1855 and 1931. Methods: A bibliographic review of the main scientific databases and search engines, as well as specialized libraries in the history of nursing, has been carried out. The inclusion criteria were: documents that analyzed the functions of military practitioners, nurses; as well as their rank and rank. Results: Starting in 1855 with the organization of the Facultative Scale, the figure of military practitioner ceased to be a figure destined to be a future doctor to incorporate their own functions and responsibilities. The Moroccan War implied that military logistics specialized, creating aircraft for military tactics with the opening of the Cuatro Vientos aerodrome (Madrid) in 1911 and carrying out the first Spanish air evacuation mission in the same Rif War in 1922. It would not be until 1988 when the woman was able to join the Army as a professional soldier. Conclusion: The contributions of the Spanish army and aeronautics to the nursing profession lie mainly in three large fields: the extra-hospital field, the field of general and vascular surgery, and the field of traumatology. (AU)

Curación por segunda intención de una herida: estimulación de los bordes epiteliales con vitamina E acetato nebulizada / Second intention healing of a wound: stimulation of the epithelial borders with vitamin E acetate spray

En la actualidad, el cuidado de las heridas que deben curar por segunda intención se realiza en ambiente húmedo y empleando la estrategia TIME, las personas que las padecen sufren una disminución de la calidad de vida. El objetivo de este trabajo es presentar un abordaje y tratamiento del borde epitelial con vitamina E acetato nebulizada. Se trata de un paciente de 74 años y con diabetes mellitus tipo 2, que presenta una herida en la cara anterior de la pierna izquierda. El principal diagnóstico de enfermería fue integridad tisular. Como principales resultados se han establecido la hidratación de los bordes perilesionales y la disminución del tamaño de la herida. Como conclusión, la vitamina E acetato ha permitido la conservación y mejora del estado del tejido perilesional y del nuevo formado, así como el ahorro de tiempos de exposición de la lesión al ambiente (AU)

At present, the care of wounds that must heal by secondary intention is carried out in a humid environment and using the TIME strategy, the people who suffer from them suffer a decrease in quality of life. The objective of this work is to present an approach and management of the epithelial border with nebulized vitamin E acetate. The case deals with a 74-year-old patient with type 2 diabetes mellitus who presented a wound on the front of his left leg. The main nursing diagnosis has been tissue integrity. As main results, the hydration of the peri-lesion edges and the reduction in the size of the wound have been established. In conclusion, vitamin E acetate has allowed the conservation and improvement of the state of the peri-injury tissue and of the newly formed tissue, as well as the saving of exposure times of the injury to the environment (AU)

Curso y final de la vida profesional de Elvira López Mourín / Course and professional end of the nurse elvira lópez mourín

Introducción: Elvira López Mourín fue una enfermera profesional y militar que formó parte de la primera promoción de enfermeras profesionales de la Cruz Roja española. Se trasladó al Hospital de Melilla para atender las demandas sani tarias de la Guerra del Rif. Su participa ción en el acto del primer vuelo sanitario español la convirtió en noticia en los me dios de la época y ha permitido recupe rar su figura. Su recorrido profesional se pierde después del año 1933 cuando se incorpora como enfermera del Cuerpo Auxiliar Subalterno del Ejército en el Hospital Militar de Urgencia de Madrid. Objetivo: determinar el curso y final profesional de la enfermera Elvira López Mourín. Método: se realizó una revisión bibliográfica en los medios electrónicos y de biblioteca disponibles. Se solicitó a los principales archivos históricos docu mentación de sus años de servicio. Se realizaron entrevistas a tres informantes y vecinos del pueblo natal de Elvira que la habían conocido. Resultados: Elvira López Mourín presta sus servicios como enfermera profesional y militar en el Cuerpo Auxiliar Subalterno del Ejército hasta el año 1939, cuando es sometida a un Consejo de Guerra, bajo el gobierno de la dicta dura franquista, del que queda absuelta de todos los cargos. A partir del 12 de mayo de 1940 se reincorpora al Cuerpo Auxiliar Subalterno del Ejército prestando sus servicios en el Hospital Militar de Ur gencia de Madrid hasta el 4 de septiem bre de 1958 cuando se retiró. Conclusión: el acto que rememo ra a Elvira López Mourín es su exitosa participación en la primera misión de vuelo sanitario en España. Durante su carrera profesional ejerció como enfer mera en Melilla y como parte del Cuerpo Auxiliar Subalterno del Ejército en el Hospital Militar de Urgencia de Madrid (AU)

Background: Elvira López Mourín was a professional and military nurse who was part of the first promotion of professional nurses of the Spanish Red Cross. She moved to the Melilla Hospital to meet the health demands of the Rif War. Her participation in the act of the first Spanish sanitary flight made her news in the media of the time and has allowed her figure to be recovered. Her professional career was lost after 1933 when she joined the Army's Junior Auxi liary Corps as a nurse at the Madrid Emergency Military Hospital. Purpose: to determine the course and professional end of the nurse Elvira López Mourín. Methods: A bibliographic review was carried out in the available electronic and library media. Documentation of his years of service was requested from the main historical archives. Interviews were conducted with three informants and re sidents of Elvira's hometown who had known her. Results: Elvira López Mourín pro vided her services as a professional and military nurse in the Subordinate Auxiliary Corps of the Army until 1939, when she was subjected to a War Council, under the government of the Franco dictators hip, from which she was acquitted of all charges. As of May 12, 1940, she rejoi ned the Subordinate Auxiliary Corps of the Army, providing her services at the Emergency Military Hospital in Madrid until September 4, 1958, when she reti red. Conclusion: the act that comme morates Elvira López Mourín is her suc cessful participation in the first medic flight mission in Spain. During her pro fessional career, she worked as a nurse in Melilla and as part of the Subordinate Auxiliary Corps of the Army at the Madrid Emergency Military Hospital. She retired at the age of 65 in 1958 and worked as a nurse during the reign of Alfonso XIII and Victoria Eugenia and the Rif War, the dic tatorship of Primo de Rivera, the go vernment of the Second Republic, the Civil War, and the government of the Franco dictatorship (AU)

Alternativas de manejo intervencionista en el síndrome de Budd-Chiari. Serie de casos y revisión de la literatura / Interventional management alternatives in Budd-Chiari syndrome. Series of cases and review of the literature

La obstrucción en el tracto de salida del flujo venoso hepático, también conocida como síndrome de Budd-Chiari, es una condición infrecuente que causa congestión hepática, hipertensión portal, ne-crosis de los hepatocitos y, eventualmente, falla hepática aguda o crónica. Actualmente, el manejo de esta condición representa un reto para el médico, quien debe estar preparado para determinar la mejor alternativa entre las diferentes opciones terapéuticas disponibles. Este artículo pretende ilus-trar las alternativas del manejo intervencionista de esta enfermedad, a través de una serie de casos de pacientes tratados en el servicio de Radiología Intervencionista de un hospital de referencia de la ciudad de Medellín, entre 2011 y 2017.

Hepatic venous outflow tract obstruction, also known as Budd-Chiari syndrome, is a rare condition that causes hepatic congestion, portal hypertension, hepatocyte necrosis and eventually acute or chronic liver failure. Currently, the management of this condition represents a challenge for the physi-cian, who must be prepared to determine the best alternative among the different therapeutic options available. This article aims to illustrate the alternatives of interventional management of this disease, through a series of cases of patients treated in the Interventional Radiology service of a referral hos-pital in the city of Medellin, between 2011 and 2017.