Subject(s)
Brachial Plexus Neuropathies/diagnosis , Head and Neck Neoplasms/diagnosis , Neurilemmoma/diagnosis , Peripheral Nervous System Neoplasms/diagnosis , Adult , Biopsy, Needle , Brachial Plexus Neuropathies/pathology , Female , Head and Neck Neoplasms/pathology , Humans , Magnetic Resonance Imaging , Microsurgery , Neurilemmoma/pathology , Peripheral Nervous System Neoplasms/pathologyABSTRACT
By an bromodeoxyuridine (BrdU) incorporation assay, it was proved hat an IgG 1 subclass, murine monoclonal antibody to surface protein SAG2 of Toxoplasma gondii is capable of reducing the invasion and multiplication of the parasites in highly differentiated mucine secretory HT29-18N2 line cells from a human colon adenocarcinoma. This result shows the importance of surface protein SAG2 of T.gondii in invasion and further multiplication of parasites in the host cell.
Subject(s)
Antibodies, Monoclonal/pharmacology , Antigens, Protozoan/immunology , Intestinal Mucosa/cytology , Intestinal Mucosa/parasitology , Protozoan Proteins/immunology , Toxoplasma/drug effects , Toxoplasma/growth & development , Animals , Cells, Cultured , Colon/cytology , Colon/parasitology , HT29 Cells , Humans , MiceABSTRACT
PURPOSE: The best method for reconstructing the fractured orbital floor remains controversial. This article evaluates the usefulness of dehydrated human dura mater for orbital floor reconstruction after facial trauma. PATIENTS AND METHODS: A retrospective analysis of 55 patients who had undergone surgical repair of orbital fractures was performed. The dura mater was used when the disruption was less than 2 cm in diameter. Fractures were divided into 3 types: type I (blow-out), type II (orbitozygomatic fracture), and type III (midfacial fracture). The patients were followed-up at least 1 year after surgery, and the cosmetic and functional results were reviewed. RESULTS: A 7% complication rate was noted. No implant migration or infection resulted. One year postsurgery, all patients showed a complete resolution of their diplopia. CONCLUSION: The safety and biocompatibility of dehydrated human dura mater support its use in orbital defects less than 2 cm in diameter.
Subject(s)
Dura Mater/transplantation , Fracture Fixation, Internal/methods , Orbital Fractures/surgery , Accidental Falls , Accidents, Traffic , Adolescent , Adult , Age Distribution , Desiccation , Diplopia/etiology , Enophthalmos/etiology , Female , Humans , Male , Middle Aged , Ocular Motility Disorders/etiology , Orbital Fractures/complications , Orbital Fractures/etiology , Retrospective Studies , Tissue Preservation/methods , Treatment Outcome , ViolenceABSTRACT
BACKGROUND: Numerous prognostic factors have been studied for survival in patients with papillary thyroid carcinoma (PTC), although there are few multivariate studies that include the histological variety of PTC. HYPOTHESIS: There are prognostic factors that influence survival in a series of patients with PTC, including the histological variety, and a new prognostic index (PI) for survival can be formulated by accounting for these factors. DESIGN: A retrospective study. SETTING: A university hospital department of surgery. PATIENTS: Between January 1970 and December 1995, 200 patients undergoing surgery for PTC were observed (mean follow-up, 8 years). MAIN OUTCOME MEASURES: A univariate analysis was done for survival rates using the Kaplan-Meier estimation method. The possible prognostic factors were evaluated using a multivariate analysis according to the Cox model. We formulated a PI and defined 3 risk groups (low, medium, and high) for mortality. RESULTS: Of the 200 patients, 175 (87.5%) are still alive. Of the 25 deaths, 19 (9.5%) were due to the tumor. The survival was 97.5% at 1 year, 92.8% at 5, 89.5% at 10, and 83.9% at 15 and 20 years. The prognostic factors obtained after the multivariate analysis were age, tumor size, extrathyroid spread, and histological variant of the PTC. The PI is calculated as follows: PI = (2 x size) + (6 x spread) + (2 x variant) + (3 x age). As for the risk groups, the low-risk group showed a mortality of 0%; the medium-risk group, 17.1%; and the high-risk group, 76.5%. CONCLUSIONS: The histological variety of PTC has prognostic value for survival in patients with PTC. As risk factors for PTC mortality, we consider an age of 50 years or older, a tumor larger than 4 cm, the existence of extrathyroid spread, and a certain histological subtype of PTC. With these risk factors, it is possible to formulate a PI and classify patients into low-, medium-, and high-risk groups for mortality.
