ABSTRACT
OBJECTIVES: As community viral load (CVL) measurements are associated with the incidence of new HIV-1 infections in a population, we hypothesized that similarly measured community drug resistance (CDR) could predict the prevalence of transmitted drug resistance (TDR). METHODS: Between 2001 and 2011, the prevalences of HIV-1 drug resistance for patients with established infection receiving HIV care (i.e. CDR) and TDR in recently infected patients were determined in San Diego. At each position in HIV-1 reverse transcriptase (RT) and protease (pro), drug resistance was evaluated both as the overall prevalence of resistance-associated mutations and by weighting each resistance position to the concurrent viral load of the patient and its proportion to the total viral load of the clinic (CVL). The weighting was the proportion of the CVL associated with patients identified with resistance at each residue. Spearman ranked correlation coefficients were used to determine associations between CDR and TDR. RESULTS: We analysed 1088 resistance tests for 971 clinic patients and baseline resistance tests for 542 recently infected patients. CDR at positions 30, 46, and 88 in pro was associated with TDR between 2001 and 2011. When CDR was weighted by the viral load of patients, CDR was associated with TDR at position 103 in RT. Each of these associations was corroborated at least once using shorter measurement intervals. CONCLUSIONS: Despite evaluation of a limited percentage of chronically infected patients in San Diego, CDR correlated with TDR at key resistance positions and therefore may be a useful tool with which to predict the prevalence of TDR.
Subject(s)
Drug Resistance, Viral , HIV Infections/virology , HIV-1/drug effects , Adult , Analysis of Variance , Anti-HIV Agents/therapeutic use , CD4 Lymphocyte Count , California/epidemiology , Cohort Studies , Drug Resistance, Viral/genetics , Female , HIV Infections/drug therapy , HIV Infections/epidemiology , HIV Infections/genetics , HIV Protease/genetics , Humans , Male , Middle Aged , Mutation , Prevalence , RNA, Viral/genetics , RNA-Directed DNA Polymerase/genetics , Viral LoadABSTRACT
Objetivo: Identificar las tendencias naturales de aciertos y calcular el punto de corte para 6 pruebas de procesos centrales de la audición (PCA): fusión binaural, palabra filtrada, dígitos dicóticos, patrones de frecuencia y patrones de duración y sonidos ambientales en el niño de 5, 7, 9 y 11 años de edad. Material y método: Se evaluaron 369 niños de la escuela pública urbana del Estado de Puebla con 6 pruebas de PCA, dos binaurales y 4 monoaurales; utilizando un audiómetro Madsen a 50dB SL re/umbral en 1 kHz, por medio de disco grabado en el Centro de Ciencias Aplicadas y Desarrollo Tecnológico de la Universidad Nacional Autónoma de México e Instituto Nacional de Rehabilitación. Resultados: Se determinaron los puntos de corte para las 6 pruebas incluidas y se determinó que tres pruebas son útiles. Adicionalmente los resultados obtenidos en niños de 11 años difirieron de los obtenidos en niños de menos de 11 años. Conclusión: Los resultados significan un avance en los criterios normativos en materia de las pruebas psicoacústicas para PCA en español y en un contexto socioeducativo frecuente en el país. Se requiere evaluar estos resultados frente a condiciones de trastornos en PCA (AU)
Objective: To identify the natural tendencies of hits and calculate the cut-off for a test group of central auditory processes (CAP): binaural fusion, filtered words, dichotic digits, frequency patterns and duration patterns, and ambient sounds in normal 5-, 7-, 9-, and 11-year-old children. Material and methods: We studied 369 children (738 ears) who attend public schools in Puebla City, administering 6 CAP tests (2 binaural and 4 monaural); we used an audiometer at 50dB SL re-threshold at 1kHz, from a CD recorded at the CCECADET-UNAM-INR (Centre for Applied Science and Technological Development at the National Autonomous University of Mexico and the National Institute for Rehabilitation). Results: We determined the cut-off points for the 6 tests. Conclusion: This information represents an advance in the normative standards in the field of psychoacoustic tests for CAP in Spanish and in the socio-educational context prevalent in Mexico. It is important to evaluate these results against CAP disorders (AU)
Subject(s)
Humans , Male , Female , Child , Psychoacoustics , Hearing Tests/methods , Hearing/physiology , Auditory Perception/physiology , Reference Values , Hearing Disorders/diagnosis , Auditory Diseases, Central/diagnosisABSTRACT
OBJECTIVE: To identify the natural tendencies of hits and calculate the cutoff for a test group of central auditory processes (CAP): binaural fusion, filtered words, dichotic digits, frequency patterns and duration patterns and ambient sounds in normal 5-, 7-, 9- and 11-year-old children. MATERIAL AND METHODS: We studied 369 children (738 ears) who attend public schools in Puebla City, administering 6 CAP tests (two binaural and four monaural); we used an audiometer at 50dB SL re-threshold at 1 kHz, from a CD recorded at the CCECADET-UNAM-INR (Centre for Applied Science and Technological Development at the National Autonomous University of Mexico and the National Institute for Rehabilitation). RESULTS: We determined the cutoff points for the six tests. CONCLUSION: This information represents an advance in the normative standards in the field of psychoacoustic tests for CAP in Spanish and in the socio-educational context prevalent in Mexico. It is important to evaluate these results against CAP disorders.
