ABSTRACT
Se estudian las complicaciones arteriales (CA) ocurridas en 400 trasplantes realizados entre 1997 y 2006. Se dividen en 2 grupos según el tipo de tratamiento realizado: grupo i: tratamiento invasivo (tratamiento sobre la arteria o retrasplante), y grupo ii: tratamiento conservador o sintomático. Se analizan el impacto del tratamiento sobre la supervivencia y las complicaciones biliares (CB).Resultados Se han presentado 18 CA (4,5%), 10 complicaciones precoces (7 trombosis y 3 estenosis) y 8 complicaciones tardías (5 trombosis y 3 estenosis). El 90% de las complicaciones precoces se trató de forma invasiva (4 trombectomías urgentes, un retrasplante, 3 angioplastias y una ligadura de arteria hepática), y el 25% de las complicaciones tardías se trató con retrasplante (3); el 75% restante recibió tratamiento sintomático. Resultados La supervivencia a 12 y 60 meses fue inferior en el grupo ii (el 57 y el 42%) que en el grupo i (el 90 y el 68%), aunque sin alcanzar significación estadística. La tasa global de CB de enfermos con trombosis arterial fue del 50%. En el grupo i del %, significativamente menor que el grupo ii con el 71% (p<0,04).Conclusiones El tratamiento invasivo de las CA en el trasplante hepático se asocia a una mayor supervivencia a corto plazo y reduce de forma significativa la aparición de CB. En nuestra experiencia, los pacientes se benefician de un diagnóstico precoz y un tratamiento intensivo en este tipo de complicaciones (AU)
Abstract A study was made of the arterial complications documented in 400 transplants performed between 1997 and 2006. The patients were divided into two groups according to the type of treatment provided. Group I: invasive management (arterial treatment or re-transplant), and Group II: conservative or symptomatic management. The impact of management upon survival and biliary complications was analysed. Results There were 18 arterial complications (4.5%): 10 early (7 thromboses and 3 stenoses) and 8 late (5 thromboses and 3 stenoses). Ninety percent of the early complications were subjected to invasive management (4 emergency thrombectomies, 1 re-transplant and 3 angioplasties), while 25% of the late complications were treated in the form of re-transplant and the remaining 75% were subjected to symptomatic treatment. Survival after 12 and 60 months was lower in Group II (57% and 42%) than in Group I (90% and 68%), although without reaching statistical significance. The overall biliary complications rate among the patients with arterial thrombosis was 50%. The rate was significantly lower in Group I than in Group II (10% versus 71%) (P<04).Conclusions Invasive management of the arterial complications of liver transplantation is associated with longer short-term survival and significantly fewer biliary complications. In our experience, patients benefit from an early diagnosis and aggressive management of complications of this kind (AU)
Subject(s)
Humans , Male , Female , Middle Aged , Hepatic Artery , Arterial Occlusive Diseases/etiology , Arterial Occlusive Diseases/therapy , Liver Transplantation/adverse effects , Arterial Occlusive Diseases/epidemiology , Biliary Tract Diseases/epidemiology , Biliary Tract Diseases/etiology , Liver Transplantation/mortality , Retrospective Studies , Survival RateABSTRACT
UNLABELLED: A study was made of the arterial complications documented in 400 transplants performed between 1997 and 2006. The patients were divided into two groups according to the type of treatment provided. Group I: invasive management (arterial treatment or re-transplant), and Group II: conservative or symptomatic management. The impact of management upon survival and biliary complications was analysed. RESULTS: There were 18 arterial complications (4.5%): 10 early (7 thromboses and 3 stenoses) and 8 late (5 thromboses and 3 stenoses). Ninety percent of the early complications were subjected to invasive management (4 emergency thrombectomies, 1 re-transplant and 3 angioplasties), while 25% of the late complications were treated in the form of re-transplant and the remaining 75% were subjected to symptomatic treatment. Survival after 12 and 60 months was lower in Group II (57% and 42%) than in Group I (90% and 68%), although without reaching statistical significance. The overall biliary complications rate among the patients with arterial thrombosis was 50%. The rate was significantly lower in Group I than in Group II (10% versus 71%) (P<04). CONCLUSIONS: Invasive management of the arterial complications of liver transplantation is associated with longer short-term survival and significantly fewer biliary complications. In our experience, patients benefit from an early diagnosis and aggressive management of complications of this kind.
Subject(s)
Arterial Occlusive Diseases/etiology , Arterial Occlusive Diseases/therapy , Hepatic Artery , Liver Transplantation/adverse effects , Arterial Occlusive Diseases/epidemiology , Biliary Tract Diseases/epidemiology , Biliary Tract Diseases/etiology , Female , Humans , Liver Transplantation/mortality , Male , Middle Aged , Retrospective Studies , Survival RateABSTRACT
OBJECTIVES: To assess the incidence and type of biliary complications in liver transplantation after biliary reconstruction with or without a biliary tutor. MATERIAL AND METHOD: A prospective, non-randomized study of 128 consecutive patients undergoing elective liver transplantation was performed. Retransplantations, emergency transplantations, hepaticojejunostomy and patients who died within 3 months of causes other than biliary complications were excluded. Group I (n = 64) underwent termino-terminal choledochocholedochostomy with a Kehr tube and group II (n = 64) underwent choledochocholedochostomy without Kehr tube. Complications, therapeutic procedures, reoperations and survival free of biliary complications were analyzed. RESULTS: The overall rate of biliary complications was 15% (17% in group I and 14% in group II). Types of complication (overall and in groups I and II, respectively) consisted of fistulas 4% (6% vs. 3%), stenosis 8% (4% vs. 12%), and Kehr dysfunction 3%. The mean number of therapeutic procedures, including endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography, trans-Kehr cholangiography and drainage of collections, was 2.1 vs. 2 per complicated patient. The overall reoperation rate was 5% (2% vs. 9%) (p < 0.05). One-year survival free of biliary complications was 85% vs. 82% (Log Rank = 0.5). CONCLUSIONS: No statistically significant differences were found in complications after choledocho-choledocho anastomosis with or without a biliary tutor. However, the patient group that did not receive a biliary tutor required more complex procedures for treatment of complications, as well as a greater number of reoperations.
Subject(s)
Choledochostomy/instrumentation , Liver Transplantation , Female , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
Objetivos. Evaluar la incidencia y el tipo de complicaciones biliares en el trasplante hepático tras la reconstrucción biliar con y sin tutor biliar. Material y método. Estudio prospectivo no aleatorizado en el que se incluyó a 128 pacientes consecutivos sometidos a trasplante hepático electivo, excluyendo del estudio los retrasplantes, trasplantes urgentes, hepaticoyeyunostomía y pacientes fallecidos durante los primeros 3 meses por causas distintas de las complicaciones biliares. En el grupo I (n = 64) se realizó coledococoledocostomía terminoterminal sobre tubo de Kehr y en el grupo II (n = 64), coledococoledocostomía sin tubo de Kehr. Se analizan las complicaciones, los procedimientos terapéuticos, reintervenciones y supervivencia libre de complicaciones biliares. Resultados. La tasa general de complicaciones biliares es del 15% (el 17% en el grupo I y el 14% en el grupo II). En relación con el tipo de complicaciones (grupo I contra grupo II) se observó: fístulas, 4% (el 6 contra el 3%); estenosis, 8% (el 4 contra el 12%); disfunciones del tubo de Kehr, 3%. La media de procedimientos terapéuticos, incluidos colangiografía endoscópica, colangiografía transhepática, colangiografias trans-Kehr y drenaje de colecciones, es 2,1 frente a 2 por paciente complicado. La tasa general de reintervenciones es del 5% (el 2 contra el 9%) (p < 0,05). La supervivencia libre de complicaciones biliares al año es del 85 contra el 82% (test de rangos logarítmicos, 0,5). Conclusiones. No se ha encontrado diferencias estadísticamente significativas de complicaciones tras la anastomosis coledococolédoco con y sin tutor biliar. Sin embargo, el grupo de pacientes en los que no se utilizó tutor biliar ha precisado para el tratamiento de la complicaciones procedimientos más complejos, así como mayor número de reintervenciones (AU)
Objectives. To assess the incidence and type of biliary complications in liver transplantation after biliary reconstruction with or without a biliary tutor. Material and method. A prospective, non-randomized study of 128 consecutive patients undergoing elective liver transplantation was performed. Retransplantations, emergency transplantations, hepaticojejunostomy and patients who died within 3 months of causes other than biliary complications were excluded. Group I (n = 64) underwent termino-terminal choledochocholedochostomy with a Kehr tube and group II (n = 64) underwent choledochocholedochostomy without Kehr tube. Complications, therapeutic procedures, reoperations and survival free of biliary complications were analyzed. Results. The overall rate of biliary complications was 15% (17% in group I and 14% in group II). Types of complication (overall and in groups I and II, respectively) consisted of fistulas 4% (6% vs. 3%), stenosis 8% (4% vs. 12%), and Kehr dysfunction 3%. The mean number of therapeutic procedures, including endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography, trans-Kehr cholangiography and drainage of collections, was 2.1 vs. 2 per complicated patient. The overall reoperation rate was 5% (2% vs. 9%) (p < 0.05). One-year survival free of biliary complications was 85% vs. 82% (Log Rank = 0.5). Conclusions. No statistically significant differences were found in complications after choledocho-choledocho anastomosis with or without a biliary tutor. However, the patient group that did not receive a biliary tutor required more complex procedures for treatment of complications, as well as a greater number of reoperations (AU)
Subject(s)
Male , Female , Middle Aged , Humans , Liver Transplantation/methods , Anastomosis, Surgical/methods , Choledochostomy/methods , Cholangiography/methods , Jejunostomy/methods , Liver Transplantation/trends , Liver/pathology , Liver/surgery , Prospective StudiesABSTRACT
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Subject(s)
Humans , Male , Female , Liver Transplantation , Hepatic Encephalopathy/surgery , Liver Failure, Acute/complications , Liver Transplantation/statistics & numerical data , Hepatitis, Autoimmune/complications , Hepatitis, Autoimmune/diagnosis , Budd-Chiari Syndrome/complications , Budd-Chiari Syndrome/surgery , Liver Failure/complicationsABSTRACT
BACKGROUND/AIMS: To analyze the long-term outcome of the calibrated portacaval shunt in the treatment of portal hypertension. METHODOLOGY: Between 1991 and 1996 we undertook a prospective non-randomized study, including 37 cirrhotic patients who underwent small diameter portacaval shunt with polytetrafluoroethylene H-graft, 24 cases with 8 mm and 13 cases with 10 mm. Early and late complications, and survival were analyzed. RESULTS: Overall, 28 corresponded to Child-Pugh class A, 5 to class B and 4 to class C. The cause of cirrhosis was alcoholic in 16 cases, postnecrotic in 12, mixed in 5, primary biliary cirrhosis in 2 and unknown in 1. Postoperative mortality was 10%. Long-term results, after a follow-up of 3-8 years, have shown a rebleeding rate of 12%, mainly after the third postoperative year. Some degree of encephalopathy occurred in 23% of the patients, but in no case was this chronic or incapacitating. The rate of early thrombosis was 5%, but in all cases it was repermeabilized with local thrombolysis. The late thrombosis rate was 6%. The 3-, 5- and 7-year survival rates were 79%, 57%, and 36%, respectively. These rates were not statistically related with the shunt diameter or the etiology of the cirrhosis. CONCLUSIONS: Partial portacaval shunt is a safe option for the treatment of variceal bleeding due to portal hypertension. We consider it to be the treatment of choice in a selected group of cirrhotic patients with well-preserved liver function, after previous failure of medical therapy. Furthermore, it can also be used as a bridge until liver transplantation.
