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1.
BMJ Open ; 8(3): e020243, 2018 03 30.
Article in English | MEDLINE | ID: mdl-29602852

ABSTRACT

OBJECTIVE: Hospital readmission in patients admitted for community-acquired pneumonia (CAP) is frequent in the elderly and patients with multiple comorbidities, resulting in a clinical and economic burden. The aim of this study was to determine factors associated with 30-day readmission in patients with CAP. DESIGN: A cross-sectional study. SETTING: The study was conducted in patients admitted to 20 hospitals in seven Spanish regions during two influenza seasons (2013-2014 and 2014-2015). PARTICIPANTS: We included patients aged ≥65 years admitted through the emergency department with a diagnosis compatible with CAP. Patients who died during the initial hospitalisation and those hospitalised more than 30 days were excluded. Finally, 1756 CAP cases were included and of these, 200 (11.39%) were readmitted. MAIN OUTCOME MEASURES: 30-day readmission. RESULTS: Factors associated with 30-day readmission were living with a person aged <15 years (adjusted OR (aOR) 2.10, 95% CI 1.01 to 4.41), >3 hospital visits during the 90 previous days (aOR 1.53, 95% CI 1.01 to 2.34), chronic respiratory failure (aOR 1.74, 95% CI 1.24 to 2.45), heart failure (aOR 1.69, 95% CI 1.21 to 2.35), chronic liver disease (aOR 2.27, 95% CI 1.20 to 4.31) and discharge to home with home healthcare (aOR 5.61, 95% CI 1.70 to 18.50). No associations were found with pneumococcal or seasonal influenza vaccination in any of the three previous seasons. CONCLUSIONS: This study shows that 11.39% of patients aged ≥65 years initially hospitalised for CAP were readmitted within 30 days after discharge. Rehospitalisation was associated with preventable and non-preventable factors.


Subject(s)
Community-Acquired Infections , Patient Readmission , Pneumonia , Aged , Aged, 80 and over , Community-Acquired Infections/epidemiology , Community-Acquired Infections/therapy , Cross-Sectional Studies , Female , Hospitalization , Humans , Male , Patient Readmission/statistics & numerical data , Pneumonia/epidemiology , Pneumonia/therapy , Risk Factors , Spain/epidemiology
2.
J Gen Intern Med ; 33(4): 437-444, 2018 04.
Article in English | MEDLINE | ID: mdl-29327212

ABSTRACT

BACKGROUND: The baseline health status may be a determinant of interest in the evolution of pneumonia. OBJECTIVE: Our objective was to assess the predictive ability of community-acquired pneumonia (CAP) mortality by combining the Barthel Index (BI) and Pneumonia Severity Index (PSI) in patients aged ≥ 65 years. DESIGN, PATIENTS AND MAIN MEASURES: In this prospective, observational, multicenter analysis of comorbidities, the clinical data, additional examinations and severity of CAP were measured by the PSI and functional status by the BI. Two multivariable models were generated: Model 1 including the PSI and BI and model 2 with PSI plus BI stratified categorically. KEY RESULTS: The total population was 1919 patients, of whom 61% had severe pneumonia (PSI IV-V) and 40.4% had some degree of dependence (BI ≤ 90 points). Mortality in the PSI V-IV group was 12.5%. Some degree of dependence was associated with increased mortality in both the mild (7.2% vs. 3.2%; p = 0.016) and severe (14% vs. 3.3%; p < 0.001) pneumonia groups. The combination of PSI IV-V and BI ≤ 90 was the greatest risk factor for mortality (aOR 4.17; 95% CI 2.48 to 7.02) in our series. CONCLUSIONS: The use of a bimodal model to assess CAP mortality (PSI + BI) provides more accurate prognostic information than the use of each index separately.


Subject(s)
Hospitalization/trends , Pneumonia/diagnosis , Pneumonia/mortality , Severity of Illness Index , Aged , Aged, 80 and over , Community-Acquired Infections/diagnosis , Community-Acquired Infections/mortality , Community-Acquired Infections/therapy , Female , Humans , Male , Mortality/trends , Pneumonia/therapy , Predictive Value of Tests , Prospective Studies
3.
Allergy Asthma Proc ; 38(4): 277-285, 2017 Jul 01.
Article in English | MEDLINE | ID: mdl-28668107

ABSTRACT

BACKGROUND: Influenza infection is an exacerbating factor for asthma, and its prevention is critical in older patients with asthma. OBJECTIVE: This study investigated the association between asthma and influenza-related hospitalization, in Spain, of patients ages ≥ 65 years and their clinical evolution. METHODS: A multicenter case-control study was carried out in 20 Spanish hospitals during the 2013-2014 and 2014-2015 influenza seasons. Patients ages ≥ 65 years hospitalized with laboratory-confirmed influenza with and without asthma were matched with controls according to the presence of asthma, sex, age, hospital, and date of hospitalization. RESULTS: A total of 561 patients with influenza (15.9% with asthma) and 1258 patients without influenza (8.0% with asthma) were included as cases and controls, respectively. The adjusted risk of influenza for patients with asthma was calculated by multivariate conditional logistic regression. The adjustment variables were the following: smoker/nonsmoker, pneumonia in the 2 years before hospital admission, previous oral treatment with corticosteroids, influenza vaccination during the seasonal campaign, Barthel index (ordinal scale used to measure performance in activities of daily living), level of education, obesity, and the presence of other comorbidities. Patients with asthma presented a great risk of influenza (adjusted odds ratio 2.64 [95% confidence interval, 1.77-3.94]). Compared with patients without asthma, patients with asthma had more symptoms, and these had been present for longer before admission but presented a lower hospital or postdischarge mortality. CONCLUSION: This study indicated that asthma was associated with hospitalization from influenza A infection. Although patients with asthma and with influenza had more symptoms, hospital or postdischarge mortality was lower, probably due to a better response to medical treatment.


Subject(s)
Asthma/epidemiology , Hospitalization , Influenza, Human/epidemiology , Age Factors , Aged , Aged, 80 and over , Asthma/diagnosis , Asthma/mortality , Case-Control Studies , Chi-Square Distribution , Female , Hospital Mortality , Humans , Influenza A virus/isolation & purification , Influenza, Human/diagnosis , Influenza, Human/mortality , Influenza, Human/virology , Logistic Models , Male , Multivariate Analysis , Odds Ratio , Patient Discharge , Prognosis , Risk Factors , Spain/epidemiology , Time Factors
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