1.
Gen Pharmacol
; 30(4): 521-4, 1998 Apr.
Article
in English
| MEDLINE
| ID: mdl-9522169
ABSTRACT
1. A study has been made to know the effects of clozapine and clothiapine on the responses of rat isolated vas deferens to norepinephrine, dopamine and potassium, those of the rat isolated uterus to serotonin and potassium, and that of guinea pig isolated ileum to histamine. 2. Clozapine was a noncompetitive antagonist to norepinephrine, dopamine, serotonin and histamine; it inhibited potassium-induced contraction in isolated rat uterus and vas deferens. 3. Clothiapine was a competitive antagonist to serotonin and a noncompetitive antagonist to norepinephrine, dopamine and histamine; it inhibited potassium-induced contractions in isolated rat uterus and vas deferens.
Subject(s)
Antipsychotic Agents/pharmacology , Clozapine/pharmacology , Dibenzothiazepines/pharmacology , Ileum/drug effects , Muscle Contraction/drug effects , Uterus/drug effects , Vas Deferens/drug effects , Animals , Dose-Response Relationship, Drug , Female , Guinea Pigs , Ileum/physiology , Male , Rats , Rats, Wistar , Uterus/physiology
2.
Rev Clin Esp
; 189(8): 391-2, 1991 Nov.
Article
in Spanish
| MEDLINE
| ID: mdl-1784806
