ABSTRACT
Between July and October 1987 an outpatient study of 191 children with acute diarrhea was undertaken in two rural communities in Mexico. Through a double-blind randomization we compared the efficacy of a combination therapy of furazolidone, 7.5 mg/kg/day, plus standard oral rehydration therapy (ORT) (96 patients) versus a placebo plus ORT (95 patients), each given for 5 days. Diarrheal stool samples were collected from all patients before therapy. By means of a two-vial transport media system the samples were sent to a university laboratory and examined for viral, bacterial, and parasitic organisms. The most commonly isolated organisms were enterotoxigenic Escherichia coli (13%) and Giardia lamblia (13%). Patients who received furazolidone plus ORT showed a greater reduction in duration of diarrhea when compared with those receiving placebo plus ORT (63.4 h versus 71.44 h). There was also a trend toward shorter duration of diarrhea in patients with Giardia who were treated with furazolidone/ORT compared with Giardia patients in the placebo/ORT group. When fecal leukocytes were present in the stool, the furazolidone/ORT-treated patients had a significantly higher percentage of clinical cures (79% versus 54%, p = 0.03) and an overall shorter duration of diarrhea (62.0 h versus 80.6 h, p = 0.055) at the end of 5 days of therapy than did the placebo/ORT-treated group.
Subject(s)
Diarrhea, Infantile/therapy , Escherichia coli Infections/therapy , Fluid Therapy , Furazolidone/therapeutic use , Giardiasis/therapy , Rehydration Solutions/therapeutic use , Diarrhea, Infantile/etiology , Double-Blind Method , Female , Humans , Infant , Male , Randomized Controlled Trials as TopicABSTRACT
El adenocarcinoma renal, conocido como el tumor renal maligno mas frecuente en el adulto, es una neoplasia poco frecuente en pacientes pediatricos. Se describe en este trabajo bajo el caso de una nina de 8 anos de edad en quien la exploracion fisica rutinaria descubrio una masa en hemiabdomen izquierdo correspondiente a un adenocarcinoma del polo inferior del rinon izquierdo, sin invasion a la capsula ni ganglios periaorticos, que curso con estado de salud satisfactorio y sin evidencia de la actividad tumoral a los 18 meses del postoperatorio. La revision de la literatura evidencia la dificultad en su diagnostico con el tumor de Wilms, lo cual solo es posible mediante los hallazgos del estudio histopatologico. En nuestro pais, el primer caso descrito correponde al Dr. Maximiliano Salas del Hospital Infantil dei Mexico y el caso presente parece ser el segundo caso publicado
