Clear Cell Hidradenoma-Basal Cell Carcinoma Collision.

ABSTRACT: A 91-year-old man presented with a tumor on the left temporal area, clinically suspicious of basal cell carcinoma. The histopathologic study showed a central solid-cystic tumor composed by 3 different types of cells (clear or finely granular cells, polygonal cells, and squamoid cells). It had a sclerotic stroma. At the periphery, another tumor composed by smaller interconnected nests was evident. Some nests were separated from the stroma by clefts. The stroma of this second tumor was highly cellular. There was a sharp delimitation between both tumors, with no transitional area. Immunochemistry demonstrated they are different tumor. A diagnosis of clear cell hidradenoma-basal cell carcinoma collision was performed. To the best of our knowledge, this is the first description of this challenging association.

Complete regression of melanoma associated with vitiligo.

A 53-year-old woman presented with vitiligo. A pigmented lesion was disclosed in the physical examination. Its histopathologic study showed the presence of a band of melanophages in an uneven distribution. Fibroplasia and telangiectasias were also observed, but neither nevus nor melanoma cells were found. A short time afterwards, the patient developed a metastasis in an inguinal lymph node. In spite of high-dose interferon treatment, the patient died two years after the diagnosis. This case associates two uncommon events: a) the whole regression of a melanoma and b) vitiligo associated with melanoma. Although both processes have a similar pathogenic mechanism, this association is exceptional and probably influences the prognosis.

Comparative study of pagetoid dyskeratosis between acrochordons and soft fibromas.

BACKGROUND: Pagetoid dyskeratosis (PD) is considered a casual finding. We can find it in some conditions, including acrochordons and soft fibromas. OBJECTIVE: (1) to compare the presence of PD in soft fibromas and acrochordons and (2) to compare PD positive fibromas and PD negative fibromas. MATERIALS AND METHODS: We reviewed all acrochordons and soft fibromas diagnosed in the General Hospital of Lanzarote, Spain, between January 2001 and December 2002. We assessed the presence of PD, size, acanthosis, basal pigmentation, and the presence of pseudohorn cysts. RESULTS: Three hundred sixty one acrochordons and 164 soft fibromas were included in this study. There were striking differences in the presence of PD, size, acanthosis, and basal pigmentation between both entities. PD positive fibromas predominated in axillas. There were no other differences between PD positive fibromas and PD negative fibromas. CONCLUSION: Although soft fibromas and acrochordons are actually fibroepithelial polyps, including the presence of PD, there are striking differences between them. Thus, both conditions have to be considered as different entities. PD could be related to friction and moisture. PD has to be distinguished from other conditions such as Paget's disease, pagetoid melanoma, koilocytes, clear cell papulosis, among others.

Sarcoidosis subcutánea, lesiones nodulares que adoptan configuraciones cordonales o en bandas / Subcutaneous sarcoidosis, nodular lesions forming cords or bands

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Malformaciones vasculares hiperqueratósicas. Aportación de 3 casos / Hyperkeratotic vascular malformations. Presentation of three cases

Las malformaciones vasculares hiperqueratósicas (hemangiomas verrugosos) son lesiones vasculares infrecuentes que se presentan desde el nacimiento. En un periodo inicial recuerdan un angioma plano o un hemangioma infantil, pero con el tiempo van adquiriendo su típico aspecto verrugoso e hiperqueratósico. Estos cambios quizá se deban a traumatismos, rascado y episodios de sangrado. Como la lesión es profunda y se extiende más allá de la lesión clínica, el tratamiento es difícil y acarrea gran número de recidivas. Presentamos 3 casos de esta malformación vascular, en dos varones de, respectivamente, 45 y 62 años y una mujer de 30. Los tres presentaban la lesión de nacimiento, y presentaban frecuentes episodios de sangrado

Hyperkeratotic vascular malformations (verrucous hemangiomas) are infrequent vascular lesions present from birth. Initially, they are reminiscent of port wine stains or childhood hemangioma, but over time they gradually take on their typical warty and hyperkeratotic appearance. These changes are probably due to trauma, scratching and bleeding episodes. Because the lesion is deep and goes beyond the clinical lesion, treatment is difficult and involves many recurrences. We present three cases of this vascular malformation, in two males aged 45 and 62 and a 30-year-old female. All three had the lesion from birth, and presented with frequent bleeding episodes

Anhidrosis segmentaria asociada a pupila de Adie: un caso de síndrome de Ross incompleto / Segmental anhidrosis associated with Adie’s pupil: an incomplete case of Ross syndrome

Se presenta un caso de una mujer de 43 años que presentaba una zona de anhidrosis localizada en la parte superior izquierda del tronco y extremidad superior ipsolateral. Se asociaba a una pupila tónica de Adie y a una zona de hiperhidrosis compensatoria en el lado contralateral. Tras 9 años de seguimiento, las alteraciones han permanecido estables. Estas alteraciones del sistema nervioso autónomo corresponden a un síndrome de Ross con expresión incompleta

We present the case of a 43-year-old woman who presented with a localized area of anhidrosis on the upper left trunk and ipsilateral upper limb. It was associated with Adie's tonic pupil and an area of compensatory hyperhidrosis on the contralateral side. After 9 years of follow up, the alterations have remained stable. These alterations of the autonomous nervous system correspond to an incompletely expressed Ross syndrome

Endometriosis cutánea umbilical asociada a mioma uterino gigante / Umbilical cutaneous endometriosis associated with a large uterine myoma

Presentamos una paciente de 44 años, que estaba siendo estudiada en el servicio de ginecología por la presencia de grandes masas abdominales, que histológicamente resultaron ser leiomiomas. Se consultó al servicio de dermatología por una tumoración umbilical asintomática, de 5 años de evolución. Al examen histológico se observaban glándulas de luces anguladas que mostraban secreción por decapitación, distribuidas por la dermis, rodeadas por una estroma celular con eritrocitos extravasados

We present a 44-year-old female patient who was being studied by the Gynecology Department because of the presence of large abdominal masses which proved to be leiomyomas on histological analysis. The Dermatology Department was consulted because of an asymptomatic umbilical tumor which had been developing for 5 years. Upon histological examination, we observed glands with angular lumens that showed decapitation secretion distributed throughout the dermis, surrounded by a cellular stroma with extravasated erythrocytes

[Segmental anhidrosis associated with Adie's pupil: an incomplete case of Ross syndrome]. / Anhidrosis segmentaria asociada a pupila de Adie: un caso de síndrome de Ross incompleto.

We present the case of a 43-year-old woman who presented with a localized area of anhidrosis on the upper left trunk and ipsilateral upper limb. It was associated with Adie's tonic pupil and an area of compensatory hyperhidrosis on the contralateral side. After 9 years of follow up, the alterations have remained stable. These alterations of the autonomous nervous system correspond to an incompletely expressed Ross syndrome.

[Hyperkeratotic vascular malformations. Presentation of three cases]. / Malformaciones vasculares hiperqueratósicas. Aportación de 3 casos.

Hyperkeratotic vascular malformations (verrucous hemangiomas) are infrequent vascular lesions present from birth. Initially, they are reminiscent of port wine stains or childhood hemangioma, but over time they gradually take on their typical warty and hyperkeratotic appearance. These changes are probably due to trauma, scratching and bleeding episodes. Because the lesion is deep and goes beyond the clinical lesion, treatment is difficult and involves many recurrences. We present three cases of this vascular malformation, in two males aged 45 and 62 and a 30-year-old female. All three had the lesion from birth, and presented with frequent bleeding episodes.

[Umbilical cutaneous endometriosis associated with a large uterine myoma]. / Endometriosis cutánea umbilical asociada a mioma uterino gigante.

We present a 44-year-old female patient who was being studied by the Gynecology Department because of the presence of large abdominal masses which proved to be leiomyomas on histological analysis. The Dermatology Department was consulted because of an asymptomatic umbilical tumor which had been developing for 5 years. Upon histological examination, we observed glands with angular lumens that showed decapitation secretion distributed throughout the dermis, surrounded by a cellular stroma with extravasated erythrocytes.