ABSTRACT
No disponible
Subject(s)
Humans , Female , Aged, 80 and over , Prosthesis-Related Infections/microbiology , Corynebacterium Infections/microbiology , Knee Prosthesis/microbiology , Prosthesis-Related Infections/diagnosis , Prosthesis-Related Infections/drug therapy , Corynebacterium/drug effects , Corynebacterium/isolation & purificationSubject(s)
Corynebacterium Infections/etiology , Corynebacterium/isolation & purification , Knee Prosthesis/adverse effects , Opportunistic Infections/microbiology , Prosthesis-Related Infections/microbiology , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Arthroplasty, Replacement, Knee , Bacterial Typing Techniques , Combined Modality Therapy , Corynebacterium/classification , Corynebacterium Infections/drug therapy , Corynebacterium Infections/microbiology , Corynebacterium Infections/surgery , Female , Humans , Knee Prosthesis/microbiology , Linezolid/therapeutic use , Opportunistic Infections/drug therapy , Opportunistic Infections/surgery , Prosthesis Failure , Prosthesis-Related Infections/drug therapy , Prosthesis-Related Infections/surgery , Reoperation , Species Specificity , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , Vancomycin/therapeutic useABSTRACT
Osteomyelitis is a rare infection that is considered to be a children's disease. Diagnosis is frequently delayed because it is an uncommon pathology and is presented in various ways. After its diagnosis and treatment, the result is favourable in children. We present a clinical case that shows difficulties in its diagnosis. A high index of suspicion should be addressed for early recognition.
La osteomielitis es una infección infrecuente considerada como una enfermedad infantil. El diagnóstico suele demorarse, ya que es una patología rara y con forma de presentación variable. Tras su diagnóstico y tratamiento, la evolución en los niños suele ser favorable. Presentamos un caso que muestra las dificultades en su diagnóstico. Debe dirigirse un alto índice de sospecha para su precoz reconocimiento.
Subject(s)
Osteomyelitis/diagnostic imaging , Patella/diagnostic imaging , Anti-Bacterial Agents/classification , Anti-Bacterial Agents/therapeutic use , Child , Humans , Male , Osteomyelitis/blood , Osteomyelitis/drug therapy , Patella/microbiology , Patella/surgery , Staphylococcus aureus/isolation & purificationABSTRACT
BACKGROUND: Total hip arthroplasty entails considerable peri-operative blood loss, which may lead to acute post-operative anaemia and red blood cell transfusion. This study was aimed at assessing whether the addition of topical tranexamic acid to our ongoing blood-saving protocol for total hip arthroplasty was effective and safe. MATERIALS AND METHODS: A pragmatic, prospective, open-label randomised study of patients scheduled for total hip arthroplasty at a single centre was conducted. Consecutive patients were randomly assigned to receive topical tranexamic acid (2 g) at the end of surgery (tranexamic group, n=125) or not (control group, n=129). A restrictive transfusion protocol was applied. Outcome measures were red blood cell loss at 24 hours after surgery, in-hospital transfusion rate, and incidence of thromboembolic complications. RESULTS: Topical tranexamic acid was effective in reducing both red cell loss (mean difference: 138 mL [95% CI 87-189 mL]; p<0.001) in the 24h after surgery and in-hospital transfusion rates (12 vs 32.6%, for the tranexamic acid and control groups, respectively; p<0.001; relative risk=0.37 [95% CI 0.22-0.63]). However, relative red cell loss and transfusion rates were higher in females than in males, irrespectively of tranexamic acid use. The beneficial effect of tranexamic acid on transfusion was restricted to patients with pre-operative haemoglobin ≥13 g/dL (5.1 vs 24.8%; p<0.001). Topical tranexamic acid was well tolerated and no clinically apparent thromboembolic complications were witnessed. DISCUSSION: The use of topical tranexamic acid after hip arthroplasty reduced red cell loss and transfusion rates; the efficacy of this strategy may be improved by reinforcing both pre-operative haemoglobin optimisation and adherence to the practice of transfusing single units of red cells.
