ABSTRACT
Background: Squamous cell carcinoma (SCC) arising in a sacrococcygeal pilonidal sinus is rare, with cases of metastatic disease being even rarer. Among published cases, almost none have reported on systemic treatment. Objective: This disease has a poorer prognosis than other forms of cutaneous SCC; therefore, our objective is to shed some light on the treatment of metastatic disease. Methods: We present a series of nine cases treated at a single center, four of whom received systemic treatment. Additionally, other previously reported cases of metastatic disease are included in an attempt to draw stronger conclusions. Results: Four patients were treated under several treatment regimens, with a median progression-free survival of only 2 months and two instances of partial response (18%). The best result was achieved with cemiplimab. Across all the cases, there was a trend toward a benefit of the use of systemic treatment (HR 0.41, 95% CI 0.15-1.12, p = 0.083; median overall survival 13 vs. 8 months). Limitations: Limitations include the significant lack of information on previously published cases and the extremely heterogeneous nature of the existing information. Conclusion: The initial systemic treatment should be an anti-PD-1, as with other SCCs. After progression on anti-PD-1, there is no strong evidence to support the recommendation of a specific treatment or sequence: options include cetuximab and/or chemotherapy (platinum, paclitaxel, 5-fluorouracyl).
ABSTRACT
Presentamos los fundamentos funcionales y reconstructivos en un caso de exenteración pélvica extendida. El propósito es analizar el defecto quirúrgico y los requerimientos reconstructivos, aspectos no suficientemente descritos en la literatura. Se trata de un varón de 62 años, con carcinoma epidermoide perineal de origen uretral (82x117x108 mm) que invadía vejiga, pelvis y fosa pararrectal. El defecto escisional fue reconstruido con un colgajo compuesto dorsal ancho-escapular-paraescapular y una malla bicapa (polipropileno y politetrafluoroetileno extendido). Describimos una reconstrucción multiplanar orientada a 3 requerimientos funcionales definidos: 1.- soporte visceral para evitar la herniación perineal; 2.- colapso del espacio muerto para minimizar el riesgo de infección; y 3.- cobertura cutánea estable en una región exigente. Sin complicaciones postoperatorias en el corto o largo plazo, el paciente puede deambular adecuadamente y se encuentra libre de enfermedad 1 año después de la intervención. Hasta donde hemos podido conocer, este caso presenta por primera vez el uso del colgajo compuesto descrito en la reconstrucción del defecto de exenteración pélvica
The article reports the functional, reconstructive rationale behind a case of extended pelvic exenteration. Our aim is to analyze the surgical defect and consequent reconstructive requirements, aspects which have not been adequately addressed in the literature. A case is presented of a 62-year-old man presenting with an 82x117x108 mm perineal squamous cell carcinoma of urethral origin invading bladder, pelvic bone and pararectal fossa. The resection defect was reconstructed with a composite latissimus dorsi-scapular-parascapular flap and a bilayer mesh (polypropylene and extended polytetrafluoroethylene). A multiplanar reconstruction is shown that addresses 3 distinct functional requirements: 1.- visceral support to prevent perineal herniation; 2.- collapse of dead space to minimize the risk of infection; and 3.- a stable skin cover for a demanding area. With no postoperative short or long-term complications, the patient is ambulating and free of disease at one-year follow-up. To the best of the authors' knowledge, this is the first report of the described composite flap in the reconstruction of the pelvic exenteration defect
Subject(s)
Humans , Male , Middle Aged , Pelvic Exenteration/methods , Plastic Surgery Procedures/methods , Free Tissue Flaps/surgery , Surgical Mesh , Carcinoma, Squamous Cell/surgery , Quality of Life , Pelvic Floor/surgery , Postoperative Period , Viscera/surgery , Lymph Node Excision/methods , Colostomy/methodsABSTRACT
BACKGROUND: The Weil and triple Weil osteotomy are widely used to treat third rocker metatarsalgia. The aim of this study was to analyze the results and complications of Weil and triple Weil osteotomy used for the treatment of third rocker metatarsalgia. METHODS: This is a report of 82 patients who were operated due to third rocker metatarsalgia from March 2004 to May 2007. A total of 76 completed the study, 68 women and eight men, with a total of 93 operated feet, 52 right and 41 left ( 17 bilateral). The clinical results were evaluated using the AOFAS score for the assessment of lesser metatarsals and interphalangeal joints, and weightbearing lateral and AP foot X-ray for radiological evaluation. RESULTS: The median AOFAS score was 90 (range, 34 to 100). We had good results in 80% and unsatisfactory in 20%. Prior to surgery 75 feet were index minus, but after all 81 feet were plus-minus. With regard to complications, we had serious recurrence of metatarsalgia in 4.3%, moderate stiffness in 60.2% (severe in one case), floating toes in 4.3% and delays in bone healing in 7.5%. CONCLUSION: We believe that Weil and triple Weil osteotomies are effective procedures in the treatment of third rocker metatarsalgia. We feel preoperative planning with tracing on the weightbearing AP radiographs is an essential step.
