1.
J Biomol Struct Dyn
; 8(4): 737-58, 1991 Feb.
Article
in English
| MEDLINE
| ID: mdl-1905551
ABSTRACT
Lowest conformational energy structures of seventeen thyrotropin releasing hormone analogs have been studied by simulated annealing. A surprising conformational similarity was observed for the peptide backbone. The possible role of each substituent in its biological activity is inferred. A composite hydrogen-bonding environment is proposed for the TRH with respect to receptor binding.