Subject(s)
Gallstones/complications , Gastric Outlet Obstruction/complications , Aged, 80 and over , Female , Gallstones/diagnosis , Gallstones/surgery , Gastric Outlet Obstruction/diagnosis , Gastric Outlet Obstruction/surgery , Humans , Multidetector Computed Tomography , Syndrome , Tomography, X-Ray ComputedABSTRACT
Molecular rearrangements of the MLL gene at the 11q23 region have been identified in most cases of infant leukemia, regardless of the phenotype. We present a case of acute myeloid leukemia which coexpressed myeloid and lymphoid markers in a 12-month-old girl. Karyotype analysis revealed the presence of a thus far unreported translocation t(10;11)(p13;p15). Although no 11q23 abnormalities were cytogenetically detectable, an MLL gene molecular rearrangement was found.
Subject(s)
Chromosomes, Human, Pair 10 , Chromosomes, Human, Pair 11 , DNA-Binding Proteins/genetics , Gene Rearrangement , Leukemia, Myeloid/genetics , Proto-Oncogenes , Transcription Factors , Translocation, Genetic , Acute Disease , Female , Histone-Lysine N-Methyltransferase , Humans , Infant , Myeloid-Lymphoid Leukemia ProteinABSTRACT
We report two cases of hyperammonemic encephalopathy in patients with multiple myeloma. This rare complication, whose pathophysiology remains unknown, is associated with disease progression and so with a very bad prognosis. We believe that this complication should be included in the differential diagnosis of encephalopathy occurring in multiple myeloma.
Subject(s)
Ammonia/blood , Brain Diseases/blood , Brain Diseases/complications , Multiple Myeloma/complications , Delirium/etiology , Delirium/metabolism , Fatal Outcome , Female , Humans , Male , Middle Aged , Multiple Myeloma/pathology , Multiple Myeloma/physiopathologyABSTRACT
We report a case of pneumococcal pericarditis in a 13-year-old boy following allogeneic BMT from an HLA-identical unrelated donor. The post-transplant course was complicated by chronic GVHD which led to reinstitution of immunosuppressive therapy. Eight months after BMT the patient developed pericarditis with cardiac tamponade, and Streptococcus pneumoniae was isolated in the pericardiocentesis fluid. This is the first reported case of pneumococcal pericarditis after BMT. Although pericardial effusions after allogeneic BMT are often sterile and related to conditioning therapy or associated with chronic GVHD, rapid microbiological investigation and empirical treatment with antibiotics are necessary. Prophylaxis for pneumococcal infection in patients with chronic GVHD is recommended.
