Internal stress and defect-related free volume in submicrocrystalline Ni studied by neutron diffraction and difference dilatometry.

A combined study of neutron diffraction and difference dilatometry on submicrocrystalline Ni prepared by high pressure torsion aims at studying the anisotropic behaviour during dilatometry and its relation to internal stress and structural anisotropy. Macroscopic stresses were undetectable in the dilatometer samples. Along with specific tests such as post cold-rolling, this shows that an observed anisotropic length change upon annealing is not caused by internal stress, but can be explained by the inherent microstructure, i.e. the anisotropic annealing of relaxed vacancies at grain boundaries of shape-anisotropic crystallites.

An abnormal pattern of embryonic development during early pregnancy in aging rats.

There is recent evidence that a decline in fertility and litter size precedes the cessation of regular estrous cyclicity in middle-aged female rats. This decline in litter size is related to a decrease in the number of normal blastocysts that are present on Day 5 of gestation, immediately prior to implantation. Thus, the pattern of embryonic development during the first 5 days of pregnancy may be altered in middle-aged rats, resulting in fewer implanting embryos and smaller litter sizes. The present study examined the ovulation rates, fertilization rates, and the patterns of embryonic development in regularly cyclic, young and middle-aged females during the first 5 days of pregnancy. Examination of the numbers of ovulated ova revealed that the ovulation rate was significantly reduced in 12- to 14-mo-old females (13 mo; 9.0 +/- 1.0/rat), but not in 9- to 11-mo-old females (10 mo; 12.2 +/- 0.8/rat), as compared to that in young animals (12.8 +/- 1.0/rat). However, there was no decrease in fertilization rate in either the 10-mo or 13-mo group. While the total numbers of embryos present on Days 2-5 were similar among all 3 groups, embryos from 10-mo females displayed a delayed pattern of development and an increased incidence of morphological abnormalities. These changes in embryo development were even more pronounced in the 13-mo group. By Day 5 of pregnancy there was a significant reduction in normal blastocysts in 10-mo (7.3 +/- 1.2/rat) and 13-mo (6.0 +/- 1.6/rat) rats, as compared to young females (10.6 +/- 0.9/rat).(ABSTRACT TRUNCATED AT 250 WORDS)