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1.
Pharm Res ; 36(7): 106, 2019 May 17.
Article in English | MEDLINE | ID: mdl-31102058

ABSTRACT

In the original manuscript, the platelet activation images of the sample treated groups, Fig. 3c were provided incorrectly.

2.
Pharm Res ; 30(2): 523-37, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23135816

ABSTRACT

PURPOSE: ß-chitin hydrogel/nZnO composite bandage was fabricated and evaluated in detail as an alternative to existing bandages. METHODS: ß-chitin hydrogel was synthesized by dissolving ß-chitin powder in Methanol/CaCl(2) solvent, followed by the addition of distilled water. ZnO nanoparticles were added to the ß-chitin hydrogel and stirred for homogenized distribution. The resultant slurry was frozen at 0°C for 12 h. The frozen samples were lyophilized for 24 h to obtain porous composite bandages. RESULTS: The bandages showed controlled swelling and degradation. The composite bandages showed blood clotting ability as well as platelet activation, which was higher when compared to the control. The antibacterial activity of the bandages were proven against Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli). Cytocompatibility of the composite bandages were assessed using human dermal fibroblast cells (HDF) and these cells on the composite bandages were viable similar to the Kaltostat control bandages and bare ß-chitin hydrogel based bandages. The viability was reduced to 50-60% in bandages with higher concentration of zinc oxide nanoparticles (nZnO) and showed 80-90% viability with lower concentration of nZnO. In vivo evaluation in Sprague Dawley rats (S.D. rats) showed faster healing and higher collagen deposition ability of composite bandages when compared to the control. CONCLUSIONS: The prepared bandages can be used on various types of infected wounds with large volume of exudates.


Subject(s)
Bandages, Hydrocolloid , Blood Coagulation/drug effects , Chitin/therapeutic use , Nanoparticles/therapeutic use , Wound Healing/drug effects , Zinc Oxide/therapeutic use , Animals , Anti-Infective Agents/chemistry , Anti-Infective Agents/therapeutic use , Bandages, Hydrocolloid/microbiology , Candida albicans/drug effects , Candidiasis/drug therapy , Cell Adhesion/drug effects , Cell Line , Chitin/chemistry , Escherichia coli/drug effects , Escherichia coli Infections/drug therapy , Freeze Drying , Humans , Nanoparticles/chemistry , Porosity , Rats , Rats, Sprague-Dawley , Staphylococcal Infections/drug therapy , Staphylococcus aureus/drug effects , Tensile Strength , Zinc Oxide/chemistry
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