Subject(s)
Gastritis, Atrophic , Stomach Neoplasms , Humans , Endoscopy , Endoscopes , Gastric MucosaSubject(s)
Precancerous Conditions , Coloring Agents , Endoscopes , Endoscopy , Humans , Precancerous Conditions/diagnosisABSTRACT
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Subject(s)
Humans , Male , Aged, 80 and over , Giant Cell Tumors/diagnosis , Lung Neoplasms/diagnosis , Tomography, X-Ray Computed , Giant Cell Tumors/surgery , Lung Neoplasms/surgery , Immunohistochemistry , Biopsy , Fatal OutcomeABSTRACT
OBJETIVO: El carcinoma urotelial de vejiga tipo "nested" o en nidos es una variante histológica rara dentro de los tumores uroteliales de vejiga. Aunque las manifestaciones clínicas son semejantes a los demás tumores de vejiga, su apariencia macroscópica puede ser equívocamente benigna, con crecimiento submucoso difícil de detectar en la cistoscopia, lo que puede retrasar el diagnóstico. MÉTODO: presentamos las características del carcinoma urotelial variante tipo nested y revisamos los diagnósticos diferenciales de esta entidad con sus posibles imitadores. RESULTADO: En este trabajo presentamos dos casos de carcinoma urotelial tipo nested que presentan, en uno de los casos, los tres patrones de crecimiento. CONCLUSIONES: Microscópicamente el carcinoma urotelial nested se caracteriza por la distribución celular en forma de nidos y túbulos. Generalmente presentan poca atipia citológica que simula un carcinoma urotelial de bajo grado, o lesiones vesicales benignas como los nidos de von Brunn o los adenomas nefrogénicos
OBJECTIVE: Nested type transitional cell carcinoma of the bladder is a rare histological variant among bladder tumors. Although clinical presentation is similar to the other bladder tumors, its macroscopic appearance may be equivocally benign, with submucosal growing which is difficult to detect on cystoscopy, so that diagnosis may be delayed. METHODS: We present the characteristics of nested type transitional cell carcinoma and review the differential diagnosis for this entity with possible counterfeiters. RESULTS: In this article, we report two cases of nested type transitional cell carcinoma that presents, in one of them, all three growing patterns. CONCLUSIONS: Microscopically nested transitional cell carcinoma is characterized by a cell distribution forming nests and tubules. They generally present low cytologic atypia simulating a low grade urothelial carcinoma, or benign bladder lesions such as von Brunn nests or nefrogenic adenoma
Subject(s)
Humans , Male , Aged , Carcinoma, Transitional Cell/pathology , Urinary Bladder Neoplasms/pathology , Urinary Bladder/diagnostic imaging , Urinary Bladder/pathologyABSTRACT
OBJECTIVE: We report 2 cases of small cell neuroendocrine carcinomas (CCP) of the urinary bladder in patients aged 37 and 80 years. CCP is a malignancy with poor prognosis. We review the literature, under the current WHO classification (2016). METHODS: Paraffin blocks were cut for HE staining and immunohistochemistry to analyze the expression of neuroendocrine differentiation. RESULTS: The main diagnosis was based on histopathologic features, which revealed a diffuse growth pattern of small cells with scant cytoplasm and hyperchromatic nuclei. The result of the additional technical immunoreaction was positive for synaptophysin and CD56. CONCLUSIONS: Our cases have been reviewed with the literature to discuss the evolution and differential diagnosis of small cell carcinoma of the urinary bladder. This is a rare tumor with very aggressive behavior and its diagnosis lies in its morphology, and immunohistochemical profile.
Subject(s)
Carcinoma, Small Cell , Urinary Bladder Neoplasms , Adult , Aged, 80 and over , Carcinoma, Small Cell/pathology , Humans , Male , Urinary Bladder Neoplasms/pathologyABSTRACT
Objetivo: Exponemos 2 casos de carcinomas neuroendocrinos célula pequeña (CCP) de vejiga urinaria en pacientes de 37 y 80 años. CCP es una neoplasia maligna de pronóstico infausto y en este trabajo, realizamos una revisión de la literatura, bajo la clasificación actual de la OMS de 2016. Métodos: Se han realizado cortes de bloques de parafina para tinción con HE y para técnicas inmunohistoquímicas con el fin de analizar la expresión de diferenciación neuroendocrina. Resultados: El diagnóstico principal se basó en las características histopatológicas, observándose un patrón de crecimiento difuso de células pequeñas con escaso citoplasma y núcleo hipercromático. El resultado de las técnicas complementarias reveló inmunorreacción positiva para sinaptofisina y CD56. Conclusiones: Nuestros casos han sido revisados junto con la literatura para discutir la evolución y el diagnóstico diferencial del carcinoma de célula pequeña de vejiga urinaria. Este es un tumor poco frecuente, de comportamiento muy agresivo y su diagnóstico reside en su morfología y perfil inmunohistoquímico (AU)
Objective: We report 2 cases of small cell neuroendocrine carcinomas (CCP) of the urinary bladder in patients aged 37 and 80 years. CCP is a malignancy with poor prognosis. We review the literature, under the current WHO classification (2016). Méthods: Paraffin blocks were cut for HE staining and immunohistochemistry to analyze the expression of neuroendocrine differentiation. Results: The main diagnosis was based on histopathologic features, which revealed a diffuse growth pattern of small cells with scant cytoplasm and hyperchromatic nuclei. The result of the additional technical immunoreaction was positive for synaptophysin and CD56. Conclusions: Our cases have been reviewed with the literature to discuss the evolution and differential diagnosis of small cell carcinoma of the urinary bladder. This is a rare tumor with very aggressive behavior and its diagnosis lies in its morphology, and immunohistochemical profile (AU)
