Synthesis of 2,3,4-Trisubstituted 2-Cyclopentenones via Sequential Functionalization of 2-Cyclopentenone.

The synthesis of differently substituted 2,3,4-triarylcyclopent-2-en-1-ones from 2-cyclopentenone via sequential functionalization of a novel 2,4-dibromo-3-(4-methoxyphenyl) cyclopent-2-en-1-one intermediate has been developed. The process provides access to selective arylation at C-4 and C-2 with a broader substrates scope, which includes heteroaryl and alkyl substitution at C-2.

Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity.

The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations.