1.
Bioorg Med Chem Lett
; 10(12): 1377-80, 2000 Jun 19.
Article
in English
| MEDLINE
| ID: mdl-10890168
ABSTRACT
A short synthesis of the NMDA receptor antagonist (rac)-Eliprodil (9) and its resolution into the enantiomers by chiral HPLC is described. The enantiomers (R)-9 and (S)-9 were found to exhibit markedly different affinities for NR2B subunit containing NMDA receptors.
Subject(s)
Excitatory Amino Acid Antagonists/chemical synthesis , Piperidines/chemical synthesis , Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors , Excitatory Amino Acid Antagonists/chemistry , Excitatory Amino Acid Antagonists/pharmacology , Piperidines/chemistry , Piperidines/pharmacology , Stereoisomerism
2.
