Subject(s)
Cytopathogenic Effect, Viral , Molluscum contagiosum virus/physiology , RNA, Viral/biosynthesis , Viral Proteins/biosynthesis , Animals , Antigens, Viral , Cell Line , Humans , Molluscum contagiosum virus/immunology , Molluscum contagiosum virus/ultrastructure , Poxviridae/growth & development , Transcription, GeneticABSTRACT
A new polymer of dextran in the form of beads, 0.1 to 0.3 mm in diameter, was applied topically to 39 cutaneous ulcers of various causes. The material, which is powerfully hydrophilic, promptly absorbed serous and purulent exudate from the surfaces of the ulcers. This action decreased the bacterial load and prevented crust formation. Healthy granulation tissue then developed quickly in many ulcers and healing time seemed to be shorter in some cases. The exudate-absorbing capability of the beads of dextran was particularly beneficial in ulcers that had uneven surfaces, undercut margins, and sinus tracts. Complete healing was achieved in some of these cases that had previously resisted many kinds of treatment. The most important undesirable effect of the beads of dextran is their tendency to dehydrate the bases of ulcers too much, which slows or stops healing in some cases. This effect may be overcome by alternating applications of the material with hydrating forms of treatment or changing entirely to such treatment when applications of the beads has removed all exudate from the ulcers. No allergic, irritant, or toxic reaction from the dextran was encountered.
Subject(s)
Dextrans/administration & dosage , Polymers/administration & dosage , Skin Ulcer/drug therapy , Aged , Dextrans/therapeutic use , Female , Humans , Leg Ulcer/drug therapy , Male , Middle Aged , Polymers/therapeutic use , Time Factors , Wound HealingABSTRACT
Benzoyl peroxide, a powerful organic oxidizing agent, was applied topically according to a carefully developed technique to cutaneous ulcers of different types. The healing time was shortened greatly by the rapid development of healthy granulation tissue and the quick ingrowth of epithelium. Exceptionally large pressure ulcers with deep cavities, undercut edges and sinus tracts were sucessfully treated, as were stasis ulcers of long duration resistant to all other therapy. There were only 13 treatment failures among the 133 cases. The slow, sustained release of oxygen by benzoyl peroxide was though to be responsible for the success. The only complications were contact irritant dermatitis in 3% and contact allergic dermatitis in 2% of patients treated.
