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The effects of imidazoacridinones, new antineoplastic agents, on the human erythrocyte membrane.
Józwiak, Z; Pacholska, M; Szwarocka, A.
Biochem Mol Biol Int ; 43(4): 883-90, 1997 Nov.
Article in English | MEDLINE | ID: mdl-9385448

ABSTRACT

In the present study, the interactions of imidazoacridinones, C-1311 and C-1371 with human erythrocyte membranes were examined by electron spin resonance spectroscopy (ESR). It was observed that both compounds C-1311 and C-1371 preferentially bind to proteins producing the conformational changes of erythrocyte membrane skeletal proteins.


Subject(s)
Aminoacridines/pharmacology , Antineoplastic Agents/pharmacology , Erythrocyte Membrane/drug effects , Aminoacridines/chemistry , Biological Transport/drug effects , Cytoskeletal Proteins/chemistry , Cytoskeletal Proteins/drug effects , Electron Spin Resonance Spectroscopy , Hemolysis/drug effects , Humans , Membrane Fluidity/drug effects , Protein Conformation/drug effects , Temperature
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