ABSTRACT
According to estimates, up to 25% of the world's population has fungal skin diseases, making them the most prevalent infectious disease. Several chemical classes of antifungal drugs are available to treat fungal infections. However, the major challenges of conventional formulations of antifungal drugs include poor pharmacokinetic profiles like solubility, low permeability, side effects and decreased efficacy. Novel drug delivery is a promising approach for overcoming pharmacokinetic limitations and increasing the effectiveness of antibiotics. In this review, we have shed light on microemulsions, nanoemulsions, and emulgels as novel drug delivery approaches for the topical delivery of antifungal antibiotics. We believe these formulations have potential translational value and could be developed for treating fungal infections in humans.
Fungi can make people sick and can be quite dangerous. They can cause infections on the skin and, if left untreated, they can get inside our bodies, which is not good. To treat these infections we use creams and lotions. But sometimes these creams don't work very well because the medicine does not dissolve properly, doesn't get into the skin or is unable to fully treat the fungal infection. So, instead of regular creams we can use mixtures called microemulsions, nanoemulsions and emulgels. These mixtures can be more effective at eliminating fungal infections on our skin. They work well and are an effective choice for treating these infections.
