ABSTRACT
RESUMEN: Los receptores Fcγ947; (FcγR), específicos para la inmunoglobulina G, les confieren a las células donde se expresan funciones en la respuesta inmunoinflamatoria. La heterogeneidad interindividual en la eficiencia de la función de los FcγR se ha explicado por polimorfismos en los genes que codifican 3 de estos receptores, FcγRIIa, FcγRIIIa y FcγRIIIb, los cuales han sido asociados con susceptibilidad y/o severidad en enfermedades infecciosas y autoinmunes en diferentes poblaciones. En este trabajo se analizan las características clínicas de 94 pacientes chilenos con evidencia de daño periodontal y se establece la frecuencia alélica/genotípica del polimorfismo H131R en el gen FCGR2A que codifica para el receptor FcγRIIa, así como su posible asociación con periodontitis. El polimorfismo G>A (H131R) en el gen FCGR2A se estudió por PCR en tiempo real utilizando sondas TaqMan. En el grupo estudiado se encontró un alto porcentaje de pacientes con periodontitis (86, 2%) y una asociación significativa a edad y sexo. No se observó una asociación a los alelos H o R, ni a los genotipos encontrados (H/R y R/R). Este es el primer trabajo en que se estudia el polimorfismo H131R en el FcγRIIa en población chilena en una muestra de pacientes adecuadamente caracterizados; sin embargo, creemos que es necesario estudiar un mayor número de sujetos para determinar si los polimorfismos de los genes FcγR constituyen o no posibles factores de susceptibilidad a enfermedad periodontal en población chilena.
ABSTRACT: The Fcγ receptors (FcγR) specific for the immunoglobulin G, expresses for the immune inflammatory response function. The inter individual heterogeneity in the efficiency of the FcγR function has been explained by polymorphisms in genes that encode for 3 of these receptors, FcγRIIa, FcγRIIIa and FcγRIIIb, which have been associated with susceptibility or severity in autoimmune and infectious diseases in different populations. This paper discusses the clinical characteristics of 94 Chilean patients with evidence of periodontal damage and establishes the allelic/genotypic frequency of polymorphism H131R in the FCGR2A gene, which encodes for the receptor FcγRIIa, as well as their possible association with periodontitis. Polymorphism G>A (H131R) in the gene FCGR2A was studied via real time PCR using TaqMan probes. In the study group, a high percentage of patients with periodontitis was found (86, 2%) with a significant association with age and gender. No determination could be reached as to whether the allele H or R or the genotypes found (H/R and R/R) were a factor of genetic susceptibility. This is the first study to determine the polymorphisms of the FcγR gene in a Chilean population adequately characterized; nevertheless, we believe that it is necessary to study a greater number of subjects in order to determine if the polymorphisms of the FcγR gene are a possible factors of susceptibility to periodontal disease in the Chilean population.
Subject(s)
Humans , Male , Female , Periodontal Diseases , Periodontitis , Polymorphism, Genetic , Receptors, Fc , Gene Frequency , Chile , Cross-Sectional StudiesABSTRACT
It was conducted a descriptive study of the data available at the National Statistics Division of the Ministry of Public Health on the 397 deaths caused by leptospirosis in Cuba from 1987 to 1993. Data were tabulated according to age, sex, place of residence, death date, necropsy, and occupation on dying. The years of potential life lost by the age group 0-65 were calculated. In 1993, it was observed a rough increase of the rate that reached a value of 1.03 per 100,000 inhabitants. The highest rates were registered among those over 50. The high rate attained by males determined their general behavior. The incidence of this disease rose in October, November and June. The Isle of Youth special municipality and Las Tunas were the provinces with the greatest rates. The retired were the most affected followed by the factory and agricultural workers.
Subject(s)
Leptospirosis/epidemiology , Adolescent , Adult , Aged , Child , Child, Preschool , Cuba/epidemiology , Female , Humans , Male , Middle Aged , Sentinel SurveillanceABSTRACT
Data available at the National Statistics Division of the Ministry of Public Health were studied aimed at characterizing mortality due to acute diarrheal diseases (ADD). 2,934 persons died for this reason in Cuba from 1987 to 1993. Data were tabulated according to age groups, sex, occupation, province of residence, death date and necropsy. Lost potential years of life were calculated and tests of statistical significance were applied to the differences found. It was observed that mortality due to ADD tended to increase during the last 4 years studied, and that 62% of the dead patients were retired and housewives. 16% of the total of the lost potential years of life by all infectious causes was missed due to ADD. There was a predominance of mortality in the group 65 and over. Mortality was higher among males and the most affected provinces were the eastern provinces, Camagüey and the Isle of Youth special municipality.
Subject(s)
Diarrhea/mortality , Acute Disease , Adolescent , Adult , Aged , Child , Child, Preschool , Cuba/epidemiology , Female , Humans , Infant , Male , Middle AgedABSTRACT
The data available at the National Statistics Division of the Ministry of Public Health about the 414 death caused by tuberculosis in Cuba during 1987-1993 were studied. They were tabulated by age group, sex, province of residence, month of death, and necropsy. It was observed a gradual increase of the rate from 1991 on, amunting to 7.82 per 1 million inhabitants in 1993. The years of potential life lost (3,114) were calculated. Mortality in the male sex determined the rise of the rate during that period (p < 0.05). Deaths predominated among individuals over 65 with a rate of 26.09 per 100,000 inhabitants. Most of the deaths occurred in October. The provinces with the highest mortality rates due to tuberculosis were applied to the differences found.
