ABSTRACT
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Subject(s)
Humans , Cardiopulmonary Resuscitation/methods , Heart Arrest/therapy , Emergency Medical Services/methodsABSTRACT
Se presenta un caso de teratoma quístico maduro de ovario que contiene numerosas esférulas flotantes en el quiste. Se trataba de quiste de ovario gigante en una paciente en edad fértil. Las imágenes ecográficas y de la resonancia magnética destacan por su extraordinaria rareza y se piensa que son patognomónicas de teratoma quístico. El análisis anatomopatológico confirmó este resultado
We present a case of mature cystic teratoma of the ovary containing numerous spherules floating in the cyst. Sonography and MR imaging revealed spherical structures, which is thought to be pathognomonic for a cystic teratoma. Microscopically, the pathological report confirmed this finding. The cyst appears as a massive tumor in a reproductive age patient
Subject(s)
Humans , Female , Adult , Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/pathology , Ovarian Cysts/diagnosis , Ovarian Cysts/pathology , Teratoma/diagnosis , Teratoma/pathology , Magnetic Resonance Imaging , Tomography, X-Ray Computed , UltrasonographyABSTRACT
The production of Pertussis Vaccine was reevaluated at the Instituto Nacional de Higiene "Rafael Rangel" in order to optimise it in terms of vaccine yield, potency, specific toxicity and efficiency (cost per doses). Four different processes, using two culture media (Cohen-Wheeler and Fermentación Glutamato Prolina-1) and two types of bioreactors (25 L Fermentador Caracas and a 450 L industrial fermentor) were compared. Runs were started from freeze-dried strains (134 or 509) and continued until the obtention of the maximal yield. It was found that the combination Fermentación Glutamato Prolina-1/industrial fermentor, shortened the process to 40 hours while consistently yielding a vaccine of higher potency (7.91 +/- 2.56 IU/human dose) and lower specific toxicity in a mice bioassay. In addition, the physical aspect of the preparation was rather homogeneous and free of dark aggregates. Most importantly, the biomass yield more than doubled those of the Fermentador Caracas using the two different media and that in the industrial fermentor with the Cohen-Wheeler medium. Therefore, the cost per doses was substantially decreased.
