ABSTRACT
The article presents a clinical case of observation of the course of pregnancy and delivery in women with a rare manifestation of Crohn's disease with a primary lesion of the anal canal with extraintestinal manifestations (perianal region and external genitalia). Prospective clinical observation demonstrates the possibility of work with adequate outpatient and inpatient obstetric services in collaboration with relevant specialists, a favorable course and outcome of pregnancy in women with Crohn's disease of moderate severity with extraintestinal manifestations in the phase of incomplete remission and the birth of healthy full-term newborns, It should be noted that the use of drugs for the treatment of Crohns disease and related complications (anemia) had no teratogenic effects on the growth and development of the fetus, and on and on the health of the newborn Joint management of these patients by the obstetrician-gynecologist, gastro-enterology and a proctologist in the form ofjoint inspections and allows councils, in a timely manner to verify diagnosis of the disease and its complications, and provide adequate correction treatment patient to obtain a favorable pregnancy outcome, birth and the postnatal period.
Subject(s)
Anus Diseases , Crohn Disease , Genital Diseases, Female , Pregnancy Complications , Adult , Anus Diseases/diagnosis , Anus Diseases/pathology , Anus Diseases/therapy , Crohn Disease/diagnosis , Crohn Disease/pathology , Crohn Disease/therapy , Female , Genital Diseases, Female/diagnosis , Genital Diseases, Female/pathology , Genital Diseases, Female/therapy , Humans , Pregnancy , Pregnancy Complications/diagnosis , Pregnancy Complications/pathology , Pregnancy Complications/therapyABSTRACT
Eighty-nine pregnant women, including 62 pregnant females with pyelonephritis, were examined. After bacteriophage treatment for pyelonephritis, there was an increase in the content of iron, a decrease in the level of soluble transferrin receptor without iron therapy, suggesting iron redistribution in pregnant woman. The blood levels of copper, ceruloplasmin, and transferrin in pregnant women with pyelonephritis point to antioxidative defense activation in both healthy pregnant women and pregnant females with pyelonephritis. The serum concentration of ceruloplasmin is of importance for prognosis and evaluation of ceruloplasmin in pregnant women. The higher content of ceruloplasmin in pregnancy is indicative of the involvement of protective mechanisms from autoaggression.
Subject(s)
Bacteriophages , Copper/blood , Iron/blood , Pregnancy Complications/therapy , Pyelonephritis/therapy , Anti-Bacterial Agents/therapeutic use , Ceruloplasmin/analysis , Female , Humans , Pregnancy , Pregnancy Complications/metabolism , Pyelonephritis/metabolism , Transferrin/analysisABSTRACT
The results of the study of the effectiveness of using vaccine Vaxigrip for the prophylaxis of influenza in organized groups of adults are presented. The vaccine was found to have high epidemiological effectiveness (the epidemiological index was 2.6), moderate reactogenicity and pronounced immunological activity (the protection level was 89.0-100.0%). The vaccine may be recommended for the prophylaxis of influenza among adults.
