ABSTRACT
Ovarian hyperstimulation syndrome is usually an iatrogenic complication in women taking ovulation induction medications during assisted reproduction. We hereby report the case of a 25 years old female who presented with hypertension, polyserositis with tense ascites and large cystic ovaries. She developed sigmoid and transverse sinus thrombosis. She had undergone a clandestine ovulation induction therapy as a commercial ovum donor. She fitted in severe category of ovarian hyperstimulation syndrome.
Subject(s)
Ascites , Hypertension , Lateral Sinus Thrombosis , Ovarian Hyperstimulation Syndrome , Ovary , Ovulation Induction/adverse effects , Serositis , Adult , Ascites/diagnosis , Ascites/etiology , Diagnosis, Differential , Disease Management , Female , Humans , Hypertension/diagnosis , Hypertension/etiology , Lateral Sinus Thrombosis/diagnosis , Lateral Sinus Thrombosis/etiology , Organ Size , Ovarian Hyperstimulation Syndrome/diagnosis , Ovarian Hyperstimulation Syndrome/physiopathology , Ovarian Hyperstimulation Syndrome/therapy , Ovary/diagnostic imaging , Ovary/pathology , Ovulation Induction/methods , Serositis/diagnosis , Serositis/etiology , Severity of Illness Index , Tissue Donors , Tomography, X-Ray Computed/methodsABSTRACT
A 14-year-old male, diagnosed case of type 1 diabetes mellitus since 1 year, presented with uncontrolled blood glucose levels, non-compliance with insulin therapy and recurrent admissions with diabetic ketoacidosis. His blood glucose levels were difficult to control with wide fluctuations in insulin requirement. He had absent secondary sexual characteristics and hepatomegaly. Liver biopsy showed macrovesicularsteatosis without fibrosis or inflammation. Many glycogenated nuclei were present. He was started on intensive insulin therapy, whereby he showed subsequent regression of hepatomegaly and onset of pubertal spurt.
Subject(s)
Diabetes Mellitus, Type 1/complications , Dwarfism/etiology , Fatty Liver/etiology , Adolescent , Diabetes Mellitus, Type 1/drug therapy , Dwarfism/drug therapy , Fatty Liver/drug therapy , Humans , Male , Remission Induction , SyndromeABSTRACT
Two sisters presented with lower limb deformity and difficulty in walking without support. Both had short stature; however, neurodevelopment and secondary sexual characters were normal. Abdominal examination revealed splenomegaly and ophthalmic examination showed presence of Kayser-Fleischer (K-F) rings. Diagnosis of Wilson's disease was confirmed with low serum copper and ceruloplasmin levels. Further investigations revealed urinary acidification defect with hypercalciuria pointing towards distal renal tubular acidosis. Both patients were started on copper chelation therapy and showed gradual radiographic improvement in osteopaenia.
Subject(s)
Acidosis, Renal Tubular/etiology , Hepatolenticular Degeneration/complications , Acidosis, Renal Tubular/diagnosis , Acidosis, Renal Tubular/metabolism , Adolescent , Ceruloplasmin/metabolism , Chelation Therapy , Consanguinity , Copper/metabolism , Diagnosis, Differential , Female , Hepatolenticular Degeneration/diagnosis , Hepatolenticular Degeneration/metabolism , Humans , SiblingsABSTRACT
Acrocallosal syndrome is an extremely rare genetic disorder with autosomal recessive inheritance. It is characterised by moderate to severe mental retardation, hypotonia, agenesis of the corpus callosum and preaxial polydactyly involving both feet and the facial features like broad forehead and hypertelorism. The authors report a case of a young hypertensive male who presented with unprovoked seizures for the first time who had multiple craniofacial, digital dysmorphic features with moderate mental retardation. The diagnosis of acrocallosal syndrome was arrived at after neuroimaging showed agenesis of corpus callosum with interhemispheric cysts.
Subject(s)
Acrocallosal Syndrome/diagnosis , Hypertension/etiology , Abnormalities, Multiple/diagnosis , Abnormalities, Multiple/etiology , Acrocallosal Syndrome/complications , Acrocallosal Syndrome/pathology , Brain/abnormalities , Brain/pathology , Humans , Intellectual Disability/etiology , Magnetic Resonance Imaging , Male , Neuroimaging , Young AdultABSTRACT
Xanthogranulomatous pyelonephritis (XGP) is a rare chronic inflammatory disorder of the kidney characterised by an infectious phlegmon arising in the renal parenchyma. It is seen in patients who have urolithiasis, urinary tract infection and immunocompromised status. The clinical presentation is variable and renal neoplasm is considered as a differential due to its characteristic extrarenal visceral invasion. The treatment is almost universally extirpative and can pose a formidable challenge to the treating physician and surgeon. The authors report a rare case of XGP in a postpartal woman who presented with multiple visceral abscesses whose diagnosis was arrived on histopathological examination.
