1.
RSC Chem Biol
; 2(3): 830-834, 2021 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-34212150
ABSTRACT
Human phenol sulfotransferases mediate the transfer of a sulfuryl moiety from the activated sulfate donor PAPS to hydroxy-containing substrates, altering substrate solubility and charge to affect phase II metabolism and cell signaling. Here, we present the development, computational modeling, in vitro enzymology, and biological application of STS-3, an activity-based fluorescent sensor for the SULT1A1 isoform.