ABSTRACT
Comparative experimental evaluation of the efficiency of prostatotropic drugs Prostamol Uno and Samprost on the model of the chronic aseptic prostate inflammation in rats was performed. It was established that peptide drug Samprost decelerates sclerotic processes in the prostate gland to a greater extent than herbal preparation Prostamol Uno. Both products equally stimulate secretory activity of the gland. Prostamol Uno, unlike Samprost, prevents the development of reduced sexual motivation, one of the complications of chronic prostatitis.
Subject(s)
Anti-Inflammatory Agents/pharmacology , Plant Extracts/pharmacology , Prostatitis/drug therapy , Tissue Extracts/pharmacology , Animals , Animals, Outbred Strains , Anti-Inflammatory Agents/therapeutic use , Copulation/drug effects , Drug Evaluation, Preclinical , Male , Organ Size , Plant Extracts/therapeutic use , Prostate/drug effects , Prostate/metabolism , Prostate/pathology , Rats , Statistics, Nonparametric , Tissue Extracts/therapeutic use , Zinc/metabolismABSTRACT
Specific effects of ultra-low doses of antibodies to prostate-specific antigen obtained from laboratory rats of late reproductive age with sulpiride model of benign prostatic hyperplasia were compared with the results of clinical application of the preparation. Clinical reproducibility of experimental data was proven, which suggests that the developed model is adequate for pilot testing of the effects of pharmacotherapy of this disease.
Subject(s)
Antibodies/administration & dosage , Disease Models, Animal , Prostatic Hyperplasia/chemically induced , Prostatic Hyperplasia/drug therapy , Animals , Antibodies/therapeutic use , Drug Screening Assays, Antitumor/methods , Humans , Male , Middle Aged , Prognosis , Prostate/drug effects , Prostate/pathology , Prostate-Specific Antigen/immunology , Prostatic Hyperplasia/pathology , Rats , Rats, Wistar , Statistics, Nonparametric , Sulpiride , Treatment OutcomeABSTRACT
Morphological and functional characteristics of spermatogenesis in rats were studied during the early and delayed periods after single injection of paclitaxel (antitumor agent) in the maximum tolerated dose. The drug induced structural changes in the gonads associated with oligospermia and increased number of pathological forms of spermatozoa with reduced functional activity.
