ABSTRACT
Contribution of relationships between caudate nucleus and hippocampus, hypothalamus, amygdaloid, septum (with limbic brain emotiogenic mechanisms substrate), and neocorticoreticular mechanisms to the formation of experimental alcoholism was studied in rats. These relationships varied depending on alcoholization periods. Caudate nucleus was found to participate in mechanisms of regulation of dreamy states and sleep, as well as of quieting at early stages of alcoholization, this may be one of neurophysiologic mechanisms of development of craving to alcohol. The authors believe that transfer of the studied structures' functioning to a pathologic level at the stage of alcoholism formation may be regarded as a coarse destruction of restraining (caudate) mechanisms of reticulolimbic brain structures involving convulsive, emotional, and hyperkinetic disturbances and impairment of sleep-awakening processes.
Subject(s)
Alcoholism/etiology , Basal Ganglia Diseases/etiology , Caudate Nucleus/physiopathology , Alcoholism/physiopathology , Animals , Basal Ganglia Diseases/physiopathology , Electroencephalography/drug effects , Limbic System/physiopathology , Male , Rats , Self Stimulation/physiology , Time FactorsSubject(s)
Alcoholism/physiopathology , Nervous System/physiopathology , Alcoholism/pathology , Animals , Avoidance Learning/drug effects , Brain/pathology , Conditioning, Classical/drug effects , Electroencephalography , Nervous System/pathology , Rats , Self Stimulation , Stereotyped Behavior/drug effectsABSTRACT
The neurophysiological and pathomorphological characteristics of experimental alcoholism formation were studied in chronic experiments with 30 rats using a method of recording the electrical activity of different brain structures, the reaction of self-stimulation of the ventrolateral hypothalamus, amygdala and reticular formation of the midbrain, ECG, arterial pressure, conditioned reflexes, review and specialized histochemical methods. Derangements of the electrical activity of the brain, conditioned reflexes, emotional and cardiovascular reactions shared by the limbicoreticular structures and neocortex were found to be dependent on the time of alcoholization. Comparison of the neurophysiological and pathomorphological alterations in the brain seen in experimental alcoholism points to the structural and functional disorders contributing to the failure of the compensatory and adaptation mechanisms.
Subject(s)
Alcoholism/physiopathology , Brain/physiopathology , Disease Models, Animal , Ethanol/administration & dosage , Action Potentials/drug effects , Action Potentials/physiology , Alcoholism/pathology , Alcoholism/psychology , Animals , Blood Pressure/drug effects , Blood Pressure/physiology , Brain/pathology , Conditioning, Classical/drug effects , Conditioning, Classical/physiology , Dose-Response Relationship, Drug , Electroencephalography , Male , Rats , Stereotyped Behavior/drug effects , Stereotyped Behavior/physiology , Time FactorsABSTRACT
The role of the amigdalar complex and the hippocampus as well as their interaction with the hypothalamus in a formation of attraction to alcohol was studied in 40 rats. After electrolytic lesions of the hippocampus and the amigdalar complex at early stages of alcoholization the inhibition of development of this pathologic attraction occurred however with subsequent dynamical reorganization of the structural and functional mechanisms of alcoholic motivation and with duplication of the triggering links. Important role of the limbico-neocortical relations was revealed in a development of behavioural and emotional-vegetative disturbances accompanying experimental alcoholism.
