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Int J Pharm ; 568: 118466, 2019 Sep 10.
Article in English | MEDLINE | ID: mdl-31254623

ABSTRACT

Some recent studies have shown that pirfenidone (PFD) has favorable results in the healing process of the cornea. However, PFD in solution exhibits short half-life after topical application, and in this context, a liquid crystal nanoparticle system containing PFD (PFD-LCNPs) was developed. The nanoparticles were characterized by transmission electron microscopy, atomic force microscopy, small angle X-ray diffraction and polarized light microscopy. The PFD-LCNPs had particle size and zeta potential of 247.3 nm and -33.60 mV (stores at 4 °C), respectively, and 257.5 nm and -46.00 mV (stored at 25 °C), respectively. The pH of the formulation was 6.9 and the encapsulation efficiency was 35.9%. The in vitro release profiles indicated that PFD sustained release from PFD-LCNPs for up to 12 h. In vitro study of ocular irritation (HET-CAM test) concluded that components of the formulation are well tolerated for ocular administration. Corneal re-epithelialization time after chemical burning was significantly reduced in rabbits treated with PFD-loaded LCNPs when compared to the group treated with a vehicle. In addition, the anti-inflammatory action of pirfenidone was observed by reducing myeloperoxidase activity (MPO) and inflammatory cells in the histology of the tissues of animals treated with PFD-LCNPs. These findings indicated that the PFD-LCNPs might have the potential for effective ocular drug delivery.


Subject(s)
Analgesics/administration & dosage , Anti-Inflammatory Agents/administration & dosage , Burns, Chemical/drug therapy , Eye Burns/drug therapy , Liquid Crystals , Nanoparticles/administration & dosage , Pyridones/administration & dosage , Administration, Ophthalmic , Analgesics/pharmacokinetics , Animals , Anti-Inflammatory Agents/pharmacokinetics , Burns, Chemical/metabolism , Burns, Chemical/pathology , Chick Embryo , Chorioallantoic Membrane/drug effects , Cornea/drug effects , Cornea/metabolism , Cornea/pathology , Drug Delivery Systems , Drug Liberation , Drug Stability , Eye Burns/chemically induced , Eye Burns/metabolism , Eye Burns/pathology , Female , Particle Size , Peroxidase/metabolism , Pyridones/pharmacokinetics , Rabbits
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