[THE INFECTION INDUCED BY STREPTOCOCCUS OF SEROGROUP B IN PREGNANT WOMEN, PUERPERA AND NEWBORNS].

The streptococci of serogroup B (Streptococcus agalactiae) are one of major etiologic agents responsible for occurrence of severe perinatal infections in puerpera and newborns. The prevalence of streptococci of group B is analyzed in various categories of women (stage of preconception training, pregnancy, puerpera) and newborns transferred for particular reasons to second stage of raising. The data of microbiological monitoring during four years was involved. It is established that prevalence of carriage of streptococci of serogroup B in genital tracts of women of reproductive age on territory of Omsk consists 6-8% in different categories of female patients and has no tendency to decrease. In most cases, high or moderate level of dissemination, association with other opportunistic microorganisms. The perinatal infection of premature newborns with low body mass at birth with S. agalactiae results in clinical manifestation of generalized infectious process. The infection of healthy premature newborns most often does not result in severe infectious pathology. However; in the half of all cases development of local (significantly more rarely - generalized) pyoinflammatory induced by S. agalactiae as both isolated and in association with other opportunistic microorganisms. The relatively high rate of realization of potential of agent in newborns of risk group requires attention to the issues of diagnostic of carriage of streptococci group B in pregnant women, inclusion of this type of analysis into standards of observation for given category of female patients with purpose of timely sanitation, development and elaboration of standards of laboratory analysis on this agent.

[Ureaplasma urealyticum and Ureaplasma parvum in etiology of urogenital mixt-infections].

The complex study of 104 vaginal samples from patients with urogenital uroplasmosis was carried out. U. parvum were detected in 67.3% patients, U. urealyticum--in 12.5% and in 20.1% cases--two species were registered at the same time. Isolation of clinical significant concentration of both ureaplasma (> 10(4) CFU/ ml) was detected in about 50% of cases. Expression of inflammation of vaginal mucus depended on the level of concentration of infection agents. U. parvum were associated with bacterial vaginosis, while in urogenital candidosis U. parvum was detected rarer than U. urealyticum. The dominant numbers of clinical ureaplasma were high sensitive to "new" macrolides and chinolons, however the high percent of isolates were resistant to erytromicin and doxiciclin.

[Epidemiological aspects of cytomegalovirus infection in babies aged under one]. / Epidemiologicheskie aspekty tsitomegalovirusnoi infektsii u detei pervogo goda zhizni.

Sreening data obtained on babies aged under one and selected by random (1,910 children) or target (2,658 children) choice for cytomegalovirus (CMV) infection during the period of 10 years (1992-2001) were compared with mortality rate. The methods used were enzyme immunoassay, immunofluorescence and polymerase chain reaction. The babies were divided as follows: newborn infants (group I), babies aged 1-3 months (group II), 4-6 months (group III) and 7-12 months (group IV). Specific clinical features of CMV infection in newborn infants were studied on 69 cases (37--with CMV monoinfection and 32--with mixed infection). The serological screening revealed a 2.1-fold growth of the infection rate among randomly selected newborn infants during the 10 year period. Positive correlation between the infection rate among children of this age group and the neonatal mortality rate was established. High risk factors of CMV infection were revealed as well as increased infection rate and frequency of clinical cases with the prevailing neurological pathology in group III. Early diagnosis, the exclusion of mixed infections and early adequate therapy were shown to play a decisive role in the outcome of the disease. The algorithm of epidemiological surveillance and the regional program of prophylaxis were worked out.