ABSTRACT
Chronic neuroborreliosis is an actual problem in neurology due to its under-investigation in Russia, variety of clinical forms, and the absence of well established diagnostic criteria. We present clinical and laboratory differential diagnostic criteria of chronic borrelial encephalomyelitis in comparison with multiple sclerosis. Distinguishing characteristics of Lyme encephalopathy versus vascular encephalopathy are considered. Problems and possibilities of immunological methods for identification of B. burgdorferi are discussed. The results of the antibiotic treatment of different clinical forms of neuroborreliosis with affection of the central nervous system are described.
Subject(s)
Lyme Neuroborreliosis/diagnosis , Adult , Anti-Bacterial Agents/therapeutic use , Diagnosis, Differential , Electroencephalography , Humans , Lyme Neuroborreliosis/drug therapy , Middle Aged , Multiple Sclerosis/diagnosis , Severity of Illness Index , Young AdultABSTRACT
The impairment of the nervous system is the main clinical presentation of chronic Lyme borreliosis. Frequency and characteristics of neuroborreliosis in Russia are still under-investigated. The article contains the analysis of 160 cases of chronic Lyme borreliosis with detailed descriptions of different neurologic syndromes - radiculopathy, polyneuropathy, encephalopathy and encephalomyelitis. Epidemiology of this disease as well as its laboratory and instrumental diagnosis are discussed. Extraneural signs and symptoms of late stages of neuroborreliosis are presented. The results of antibacterial treatment of different forms of chronic neuroborreliosis are outlined.
