ABSTRACT
No disponible
Subject(s)
Child , Pediatric Emergency Medicine/organization & administration , Alcoholic Intoxication/epidemiology , Alcoholic Intoxication/prevention & control , Hospitalization/trendsSubject(s)
Alcoholic Intoxication/epidemiology , Adolescent , Child , Female , Humans , Male , Retrospective Studies , Spain/epidemiology , Time FactorsABSTRACT
OBJECTIVE: Aggressive fibromatosis is a rare illness in children. We analyzed the records of four patients, taken from a total of 505, all of which had different types of tumours, over a period of ten years. In the four cases, three were male and one female. Their ages ranged from 0-7 years old. We also did a review of this pathology. RESULTS: The illness may present itself a a painless mass found particularly in the pelvic area, knee, buttock and anterior mediastinum, respectively. Two of these cases presented lysis of osseous tissue shown in radiologic assays. The diagnosis was histological in every case. The only treatment was surgical in all of them. Two of the cases required only one intervention to achieve remission and up to now there has been no record of further illness. At the time of writing this paper the patients are alive after a follow-up period of thirty months. CONCLUSIONS: Up to now, no other alternative forms of treatment have been convincing. Adjuvant radiation and chemotherapy are probably beneficial, but the precise indication for its use is not well defined.
Subject(s)
Bone Neoplasms/diagnosis , Fibromatosis, Aggressive/diagnosis , Bone Neoplasms/surgery , Child , Child, Preschool , Female , Fibromatosis, Aggressive/surgery , Humans , Infant , Infant, Newborn , Magnetic Resonance Imaging , Male , Retrospective Studies , Tomography, X-Ray ComputedABSTRACT
OBJECTIVE: The purpose of this study was to reproduce the results obtained by the "BFM Group" in children with NHL and B-ALL treated with BFM 86 and 90 protocols. PATIENTS AND METHODS: From April 1987 until January 1997, we have treated a total of 82 children, 22 with non-B NHL, 49 B-NHL and 11 B-ALL. Forty-four of them were treated according to BFM 86 and 38 according to BFM 90 protocols. RESULTS: Ninety-four percent of the patients achieved complete remission (CR) and 15% of these relapsed, 12% of the cases of B NHL/ALL and 23% of the non-B NHL. The 5 year overall survival (Kaplan Meier) was 81% for the B NHL/ALL it was 83% and for non-B NHL 77%. The event-free survival was 75% for B-NHL, stages I and II it was 80% and stages II and IV 78%, for B-ALL 72% and for non-B NHL 68%. The median follow-up time was 50 months (12-106). CONCLUSIONS: Treatment of NHL and B-ALL with BFM protocols is an effective therapeutic choice, with reproduction of the results of the "BFM group" being feasible.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Lymphoma, Non-Hodgkin/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Adolescent , Asparaginase/administration & dosage , Bone Marrow Transplantation , Child , Child, Preschool , Combined Modality Therapy , Daunorubicin/administration & dosage , Disease-Free Survival , Female , Follow-Up Studies , Humans , Infant , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/mortality , Lymphoma, Non-Hodgkin/pathology , Male , Neoplasm Staging , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Prednisone/administration & dosage , Remission Induction , Time Factors , Vincristine/administration & dosageABSTRACT
OBJECTIVES: To evaluate the impact of the introduction of a programme for rational use of medicines (PRUM) on the pharmacotherapeutic prescription profile of the primary care teams in the Ciudad Real health area. DESIGN: A longitudinal and prospective intervention study. The Area's total general medical prescription (January, May and August, 1994 and 1995) was used. SETTING: Ciudad Real Primary Care Area of INSALUD. PARTICIPANTS: 166 general practitioners, all the prescribing doctors in the area. INTERVENTION: Introduction of a programme of rational use of medicines. MEASUREMENTS AND RESULTS: Expenditure/inhabitant, prescriptions/inhabitant, expenditure/prescription, units of drugs of low therapeutic value (LTV), cost of calcitonins/pensioner and units of hypolipaemiants/100 pensioners were measured, in function of seven variables of the prescriber and six variables of the population group. Breaking down the prescriber's variables, least expenditure/inhabitant per month corresponded to doctors over 50, followed by temporary doctors, those not in paediatrics and those with their post in an urban centre. There was a positive correlation between expenditure/inhabitant per month and the number of prescriptions issued. CONCLUSIONS: 1. After the initial phase of PRUM, an increase in expenditure and improvement in the qualitative profile of prescription were noted. 2. Information taken from the study has proved to be an adequate planning and management tool.
