ABSTRACT
OBJECTIVES: To investigate the corneal biomechanical properties of keratoconic eyes following penetrating keratoplasty (PKP). MATERIALS AND METHODS: Thirty-five patients (70 eyes) were enrolled to this prospective study. Operated and contralateral keratoconic eyes were defined as Group 1 and 2, respectively. All patients underwent ophthalmological examination and measurements of corneal biomechanical properties by Ocular Response Analyzer (ORA), intraocular pressure (IOP) by Goldmann applanation tonometry, and central corneal thickness (CCT) by Pentacam. Shapiro-Wilk W test was performed to test normality of the data. The statistical significance was evaluated with the paired t-test and Wilcoxon signed ranks test. Pearson correlation and Spearman rho tests were used for correlation analysis. RESULTS: The average age and male/female ratio were 31.34±11.65 (15-60) years and 21/14, respectively. The mean values of the data obtained from Group 1 and 2 respectively were: corneal hysteresis (CH): 9.35±1.66, 8.18±1.84 mmHg (p=0.013), corneal resistance factor (CRF): 9.48±1.96, 7.14±2.05 mmHg (p<0.001), IOPcc: 16.90±4.32, 14.26±3.69 mmHg (p=0.004), IOPg: 15.45±4.61, 10.91±3.97 mmHg (p<0.001), IOPapl: 14.26±3.11, 13.09±2.54 mmHg (p=0.046), and central corneal thickness (CCT): 545.64±60.82, 442.60±68.14 µM (p<0.001). The positive correlation between CH and CRF was moderate (r=0.444) in Group 1 and strong (r=0.770) in Group 2. There was a moderate negative correlation between CH and IOPcc in both groups (r=-0.426, r=-0.423), but CH was not correlated with IOPg or IOPapl in either group. There were weak to strong positive correlations between CRF and all IOP values in both groups. There was no correlation between CRF and CCT in Group 1 (r=0.075) and a very weak correlation in Group 2 (r=0.237). Only IOPcc and IOPg were strongly correlated in both groups. CONCLUSION: Better understanding of corneal biomechanical properties is essential for elucidating the pathophysiology and diagnosis of several corneal pathologies such as keratoconus. The biomechanical properties of keratoconic eyes seem to be closer to normal values after PKP.
ABSTRACT
OBJECTIVES: As the deceased-donor organ shortage has become a common problem, we sought to investigate the attitudes of people in Izmir, Turkey, concerning corneal donation and transplant. MATERIALS AND METHODS: A questionnaire designed to collect demographic data and determine attitudes concerning corneal donation and transplant, based on 9 questions, was prepared and administered to 1000 people that presented to our outpatient clinics in 2009. RESULTS: Among the respondents, 54.7% were willing to donate their corneas, while 84.3% were willing to receive corneas, and 15.4% were opposed corneal transplant. Attitudes toward corneal donation were significantly more positive in those with more education than in those with less education. Among participants, the ratio of a positive attitude toward donation significantly increased with decreasing age (P < .001), with a maximum of 66.7% among participants aged 18-24 years and 46.2% among those aged > 65 years. The positive attitude increased with increasing level of education. The donor parameters reported to be of the most importance were religion, nationality, country, ethnicity, and sex (31.3%, 25.1%, 23.5%, 22.8%, and 20.8%). CONCLUSIONS: The primary factor associated with negative attitudes toward organ/tissue donation and receipt is low education. This result suggests that educating and motivating the public might help increase the rate of consent for organ and tissue donation and transplant.
