ABSTRACT
New tetradentate Schiff base transition metal complexes have been derived from salicylidene-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and histidine were characterized by CHN analysis, magnetic susceptibility measurements, molar conductance, FAB-MS, IR, 1H-NMR, UV, CV, EPR, Fluorescence emission, AFM and Powder XRD techniques. AFM images and Powder XRD data endure that the complexes are nano-size grains with polycrystalline structure. The spectral evidences showed that all the metal chelates are square planar geometry except [VOL] complex which exist square-pyramidal geometry. Electrochemical data (CV) for [CuL] and [VOL] complexes in acetonitrile solution indicates that the redox potential of metal ions is affected by the coordinated ligand. Electron Spin Resonance (ESR) spectra of [CuL] and [VOL] complexes were well coinciding with proposed geometries and other reported complexes. CT-DNA interaction studies of [CuL] complex reveals that an intercalation binding mode occurs between complex and DNA base pairs. The in vitro antimicrobial activity of complexes has been tested against the growth of some fungal and bacterial species persist that chelates have better control than ligand.
ABSTRACT
Mono, di and polysaccharides of glucose (C6H12O6), sucrose (C12H24O12) and starch (C6H12O6)n bio-template ZnO nanoparticles (NPs) has prepared by chemical precipitation method. Saccharides bio-template ZnO (SBts-ZnO) NPs were efficiently prepared for their structural and optical properties were examined by using XRD, FE-SEM, AFM, FTIR, UV and PL techniques. All the samples are polycrystalline nature with a preferential orientation depending on the (1 0 1) plane. The reduction of crystalline size by utilizing glucose, sucrose and starch bio-template of ZnO NPs. FE-SEM images revealed that the spherical and nano-rods like morphologies for ZnO and SBts-ZnO NPs respectively. AFM recorded images shows spherical features that confirmed and also the morphological changes were noticed with the addition of polymers. Interaction of bio-templated saccharides (glucose G1, sucrose S2 & starch Sn) molecules was proved by FTIR study. Optical absorbance and emission behaviours were investigated using UV-Vis and photoluminescence techniques. The antibacterial study revealed that SBts-ZnO have excellent antibacterial effect than ZnO. The Sn-ZnO sample has potent antibacterial activity against the Proteus vulgaris followed by Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus.
Subject(s)
Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Nanoparticles/chemistry , Polysaccharides/chemistry , Zinc Oxide/chemistry , Escherichia coli/drug effects , Microbial Sensitivity Tests , Staphylococcus aureus/drug effects , X-Ray DiffractionABSTRACT
Carbohydrate biotemplates of glucose (C6H12O6) and starch (C6H12O6)n in to Zinc oxide (ZnO) nano thin films (NTFs) prepared for enhanced antibacterial activity by Successive Ionic Layer Adsorption Reaction (SILAR). X-ray diffraction (XRD) patterns revealed that the crystalline size values were decreased by the incorporation of carbohydrate molecules. Scanning electron microscope (SEM) and Field emission scanning electron microscope (FESEM) confirmed that the different morphologies by the addition of glucose and starch. The interactions of carbohydrate molecules with ZnO were identified by using FTIR and EDAX. Energy band gap of samples was calculated by UV absorption spectra. The emission property of Zinc oxide, Glucose/ZnO and Starch/ZnO was studied by photoluminescence (PL) spectra. The antibacterial activity of carbohydrate biotemplates (Cbts-ZnO) results showed that enhanced effect than pure ZnO for the selected pathogenic bacteria's.
