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Bioorg Khim ; 40(5): 636-8, 2014.
Article in Russian | MEDLINE | ID: mdl-25895359

ABSTRACT

For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.


Subject(s)
Oligonucleotides/chemical synthesis , Trichloroacetic Acid/chemical synthesis , Kinetics , Light , Microchip Analytical Procedures , Molecular Structure , Oligonucleotides/chemistry , Trichloroacetic Acid/chemistry
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