1.
HNO
; 63(5): 376-9, 2015 May.
Article
in German
| MEDLINE
| ID: mdl-25940008
2.
Amino Acids
; 43(3): 1399-403, 2012 Sep.
Article
in English
| MEDLINE
| ID: mdl-22160263
ABSTRACT
Light microscopic evidence suggested a synaptic role for agmatinase, an enzyme capable of inactivating the putative neurotransmitter and endogenous anti-depressant agmatine. Using electron microscopy and an alternative pre-embedding approach referred to as virtual pre-embedding, agmatinase was localised pre- and postsynaptically, to dendritic spines, spine and non-spine terminals, and dendritic profiles. In dendritic spines, labelling displayed a tendency towards the postsynaptic density. These results further strengthen a synaptic role for agmatine and strongly suggest a regulatory role for synaptically expressed agmatinase.