ABSTRACT
The kinetics of decamethoxine liberation from medical antimicrobial textiles was studied. The elution of decamethoxine was shown to be a complicated diffusive-kinetic process dependent on the exposure and concentration of decamethoxine.
Subject(s)
Anti-Infective Agents/chemistry , Decamethonium Compounds/chemistry , Occlusive Dressings , Cellulose/analogs & derivatives , Diffusion , Excipients , Kinetics , Polyvinyls , Starch/analogs & derivativesABSTRACT
Morphological investigation for studying of a local impact on the tissues, localized in the antiseptic textile implantation zone, was conducted. The textile was impregnated by composition of decametoxine with modified polysaccharides. Basing on the investigation result there was established the absence of a toxic impact of antiseptic medical textile on the macroorganism tissues, the regenerative processes course, the wounds epithelization, antioedematous and anti-inflammatory effects.
Subject(s)
Anti-Infective Agents, Local/pharmacology , Decamethonium Compounds/pharmacology , Sutures , Wound Healing/drug effects , Wounds, Penetrating/surgery , Animals , Fibroblasts/drug effects , Lymphocytes/drug effects , Macrophages/drug effects , Male , Monocytes/drug effects , Rats , TextilesABSTRACT
Antimicrobial properties of a composite based on decamethoxine and modified polysaccharides (carboxymethylamylum, oxyethyl-cellulose) were studied. The composite was shown to have high antimicrobial activity against grampositive and gramnegative bacteria under different conditions of the experiment.
